Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Commercial Real Estate Underwriting Analyst
$78K - $110K *
Unlock potential by providing timely pre and post-closing services to enhance real estate underwriting processes, ensuring compliance and efficiency in loan transactions while collaborating with vario...
5 days ago
$90K - $115K *
Drive the administration of OneStream, supporting FP&A and Accounts Payable teams. Enhance reporting, manage data integrations, and collaborate with Finance and IT to optimize processes and improve ef...
2 weeks ago
$110K - $130K *
Elevate client relationships by leading Client Success teams to ensure operational excellence, proactive issue resolution, and strategic growth, while fostering collaboration across departments to enh...
3 weeks ago
Product Manager - Clinical Member Data
$86K - $138K *
Lead the charge in defining product vision and strategy, aligning stakeholders, and overseeing execution. Collaborate across teams to prioritize clinical data assets, ensuring maximum business value a...
3 weeks ago
$76K - $120K *
Take ownership of critical operational pipelines as a Research Statistician, executing analyses and improving processes to ensure the SAT Suite runs smoothly. Collaborate with cross-functional teams t...
2 weeks ago
$113K - $188K *
Transform data into insights by developing cutting-edge machine learning models. Collaborate with multidisciplinary teams to address complex business needs using advanced analytics, ensuring data-driv...
Reposted 2 weeks ago
Data Analytics Program Manager
$120K - $130K *
Unlock potential by managing complex datasets to drive decisions across a fast-scaling energy planning function. Collaborate with cross-functional teams to ensure data integrity and operational effici...
Reposted yesterday
Program Evaluator - State & Local Outcomes (Human Services / BH / Justice)
$80K - $95K *
Analyze and lead evaluations for human-services and public programs, creating frameworks and performance measures. Collaborate with stakeholders to translate findings into actionable insights, ensurin...
3 weeks ago
Vice President, Medicaid Partnerships
$150K *
Elevate Medicaid partnerships by driving strategic sales initiatives, securing contracts, and fostering client relationships. Lead a team to achieve growth targets while navigating market dynamics and...
3 weeks ago
Strategic Data Partnership Manager
$110K - $130K *
Unlock potential by driving strategic partnerships to enhance revenue streams. Collaborate with cross-functional teams to execute joint strategies, manage relationships, and achieve sales objectives i...
Reposted 4 days ago
$90K - $110K *
Unlock potential by driving new business sales in a dynamic, AI-enabled environment. Own your territory, create a robust pipeline, and engage sophisticated buyers to deliver consistent revenue growth...
6 days ago
$190K - $230K *
Lead the accounting and financial reporting functions within a growing healthcare organization. Drive integrity across multiple entities, ensure compliance, and strategize cash management while suppor...
Reposted 6 days ago
Healthcare Program & Project Manager (Remote)
$80K - $95K *
Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...
6 days ago
$69K - $101K *
Unlock potential by delivering comprehensive clinical care management services, enhancing health outcomes for diverse populations through assessment, care planning, and coordination across multiple he...
1 week ago
$120K - $170K *
Shape the future of enterprise infrastructure by leading design, implementation, and optimization of systems. Drive automation, enhance security, and mentor junior staff while collaborating on strateg...
1 week ago
AI Administrator, Business Applications
$115K - $151K *
Grow your career with a dynamic team focused on AI tool administration and governance. Collaborate across departments to enhance system connectivity and process automation while ensuring data privacy...
Reposted yesterday
Sr Analyst Process Improvement
$80K - $95K *
Transform processes by partnering with teams to document, design, and implement effective methods. Drive project success through analysis, reporting, and change management, ensuring alignment with org...
Yesterday
Principal, Strategic Partnerships, Health Systems
$150K - $180K *
Unlock potential by driving partnerships within health systems, building strategic relationships, and creating impactful ecosystems that accelerate product adoption and streamline sales cycles, while...
Reposted 1 week ago
Clinical Documentation Integrity Lead - Service Line (Remote)
$150K - $200K *
Lead the charge in optimizing clinical documentation processes, enhancing provider education, and fostering collaboration with service line leaders to improve documentation integrity and reduce admini...
5 days ago
Director of Client Experience, Lab Network
$125K - $160K *
Drive client success in our lab network by managing relationships, ensuring renewals, and identifying growth opportunities. Collaborate across teams to enhance processes and improve client experiences...
2 weeks ago
$67K - $99K *
Lead the charge in enhancing business resilience by reviewing recovery plans, coordinating testing, and supporting incident management to ensure operational continuity during disruptions. Engage with...
1 week ago
Senior Customer Success Manager, Health Plans
$115K - $181K *
Manage and grow a diverse portfolio of health plan customers, driving satisfaction and retention. Build strategic relationships, navigate complex payor landscapes, and champion clinical outcomes to de...
6 days ago
Commercial Quality Assurance / Technical Analyst
$86K - $133K *
Elevate your career by developing quality assurance criteria and conducting analyses to ensure compliance across commercial auto lines. Collaborate with stakeholders to support effective resolutions a...
4 days ago
$120K - $140K *
Unlock potential by designing and deploying cutting-edge AI solutions that enhance enterprise operations. Collaborate across teams to create scalable, secure applications that drive efficiency and inn...
2 weeks ago
Senior Medical Stop Loss Underwriter
$79K - $127K *
Empower your career by analyzing contracts and pricing strategies to optimize profitability and growth. Utilize your underwriting expertise to assess risks, support internal initiatives, and guide tea...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.