Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$75K - $105K *
Empower healthcare delivery by ensuring coding accuracy as you analyze medical records, identify improvement opportunities, and enhance AI diagnostic models to uphold high-quality standards in inpatie...
Reposted 1 month ago
Continuous Service Improvement/Operational Excellence Analyst
$76K - $105K *
Support day-to-day operations for investment teams, collaborating across functions to enhance processes, manage budgets, and drive special projects from planning to implementation, ensuring alignment...
Yesterday
$100K - $120K *
Transform payment strategies by analyzing interchange and routing data to optimize costs and enhance performance. Leverage advanced analytics and automation to deliver actionable insights for stakehol...
5 days ago
(Remote) Cyber Vulnerability Assessment Analyst Senior - Cyber Security
$108K - $130K *
Join a team that's dedicated to enhancing cybersecurity by assessing vulnerabilities across enterprise systems and guiding remediation efforts. This senior role offers mentorship opportunities while d...
Reposted 2 days ago
$85K - $98K *
Join a dynamic team to evaluate and enhance the financial health of affordable housing organizations nationwide. Utilize advanced analytics and strategic insights to support sustainable growth and ris...
3 weeks ago
Director, NDD Business Development: Health Systems
$162K - $224K *
Elevate healthcare solutions by driving business development in neurodegenerative disease pathways. Collaborate with health systems and stakeholders to identify needs, develop strategies, and create i...
2 weeks ago
Advanced Cybersecurity Analytics Engineer III
$75K - $158K *
Innovate defensive cybersecurity strategies by analyzing data trends, developing countermeasures, and collaborating with teams to prevent compromises and enhance enterprise security. Drive proactive m...
2 weeks ago
$102K - $170K *
Lead the design and implementation of AI solutions for public health data exchange. Guide teams in creating scalable, secure systems that meet governance and interoperability standards while enhancing...
Reposted yesterday
Executive Director-Digital Product - Medical Cost Initiatives
$175K - $334K *
Lead the charge in shaping technology product strategies to enhance patient care pathways, optimize medical costs, and partner with clinical leaders, driving outcomes through innovative tech solutions...
Reposted 3 days ago
Business Development Associate
$70K - $96K *
Empower your career by joining our dynamic team to drive client engagement, identify opportunities, and develop innovative sales strategies. Collaborate with stakeholders and enhance your skills in a...
6 days ago
IT Analyst Experienced/Senior/Advanced
$111K - $139K *
Elevate your career by driving innovation in IT service management. Leverage AI solutions to enhance processes, improve customer experiences, and lead cross-functional initiatives that shape the futur...
2 weeks ago
$74K - $92K *
Empower our channel partner division by managing operational activities, coordinating RFPs, and driving cross-functional collaboration to enhance sales and partner engagement. Your insights will shape...
1 week ago
Behavioral Health Medical Director
$215K - $408K *
Drive medical management and quality improvement initiatives, ensuring effective utilization and cost containment while collaborating with clinical teams to enhance patient care and outcomes across mu...
Today
Behavioral Health Medical Director
$215K - $408K *
Grow your career with a dynamic role in behavioral health, leading medical management and quality improvement initiatives. Collaborate across diverse markets to enhance care delivery and support conti...
Today
Behavioral Health Medical Director
$215K - $408K *
Drive medical leadership in quality improvement and utilization management, ensuring effective care delivery and cost containment. Collaborate with clinical teams to enhance patient outcomes and suppo...
6 days ago
Lifecycle Acquisition Analyst, Mid
$78K - $90K *
Unlock potential by providing expert lifecycle acquisition support for NGA programs, developing key documentation, and ensuring timely procurement actions through collaboration with technical and fina...
1 week ago
Registered Nurse Acute (RN), Liberty ED - 36 hours/week, PM Shift (Open to December New Grads)
$76K - $88K *
Join us to enhance patient care through compliance, clinical judgment, and teamwork. Collaborate with interdisciplinary teams to ensure safety and quality standards while advocating for patients and f...
2 weeks ago
Contrast Media Clinical Sales Specialist
$97K - $146K *
Partner with us to provide clinical support for contrast media, delivering education and product expertise to healthcare professionals while collaborating with internal teams to enhance patient care a...
3 weeks ago
$80K - $95K *
Unlock potential by leading the design and optimization of enterprise workflows. Collaborate with cross-functional teams to enhance operational efficiency and drive data-driven decisions within a dyna...
3 weeks ago
$250K - $300K *
Transform patient care by joining a dynamic team of Radiologists, leveraging cutting-edge imaging technology and collaborating on complex cases to enhance diagnostic accuracy and efficiency in a fast...
2 weeks ago
Analyst, Privacy (Privacy Assessments)
$135K - $159K *
Drive privacy excellence by executing assessments and managing risks across products. Collaborate with Legal, Product, and Engineering to embed privacy by design and enhance frameworks that protect cu...
1 week ago
Sr. Talent Acquisition Partner
$100K - $120K *
Shape the future of executive recruitment by leading strategic sourcing, engaging high-level candidates, and collaborating with a dedicated team to uncover top talent. This role offers growth opportun...
Reposted 2 weeks ago
$80K - $95K *
Shape global sourcing strategies and enhance procurement processes through data analytics, supplier performance management, and strategic initiatives. Collaborate across teams to drive savings and ens...
2 days ago
Managing Consultant - Clinical and Operational Improvement
$102K - $170K *
Elevate your career by driving operational improvements in healthcare. Collaborate with clients to enhance performance through data analysis and strategic workflow redesign, ensuring impactful outcome...
6 days ago
$110K - $130K *
Optimize contact center strategies by leveraging virtual agent and IVR technologies. Collaborate with stakeholders to enhance operational workflows and drive performance through data analysis and inno...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.