Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$150K - $195K *
Elevate client relationships by managing key accounts, driving satisfaction and growth. Collaborate with internal teams to deliver tailored solutions, ensuring long-term success and measurable ROI for...
3 weeks ago
Client Manager, Healthcare Acquisition
$102K - $157K *
Unlock potential by driving new customer acquisition in healthcare. Engage C-suite leaders, champion innovative solutions, and lead complex sales cycles across AI and managed services to enhance patie...
4 weeks ago
$149K - $248K *
Champion client engagement and operational excellence by managing consulting teams, driving quality standards, and fostering relationships within Military Health Systems. Lead new business development...
3 weeks ago
Senior Compliance Administrator - Network, Provider, Product
$87K - $157K *
Lead the charge in executing the Medicare Compliance Advisory program, ensuring adherence to CMS regulations. Collaborate with stakeholders to provide regulatory guidance, assess compliance risks, and...
1 week ago
Senior Compliance Administrator - Clinical, SNP Model of Care, Care Management, Quality, STARs
$87K - $157K *
Drive compliance excellence by executing the Medicare Compliance Advisory program, ensuring adherence to CMS regulations. Collaborate with leadership to provide regulatory guidance, conduct audits, an...
1 week ago
$100K - $120K *
Drive impactful manager research for Mutual Funds, SMAs, and ETFs, contributing to the management of $9 billion in client assets. Collaborate with investment professionals and leverage AI tools to enh...
1 week ago
Remote - Account Executive (Healthcare Provider Solutions)
$150K - $200K *
Grow your career with a dynamic role focused on driving new business in the healthcare provider space. Leverage your sales expertise to exceed quotas, engage decision-makers, and collaborate with inte...
Today
$140K - $175K *
Empower scientific innovation by collaborating within product pods to develop and evaluate real-world evidence agents. Drive impactful research and ensure scientific rigor while partnering with indust...
2 weeks ago
Pediatric Nurse Practitioner/'Physician Assistant
$85K - $100K *
Transform pediatric healthcare by conducting assessments, developing treatment plans, and collaborating with interdisciplinary teams to enhance patient outcomes and health education for diverse popula...
3 weeks ago
$117K - $161K *
Empower our Quality Engineering operations by managing portfolio governance, financial planning, and resource allocation. Collaborate across teams to enhance transparency and execution, driving strate...
Reposted 2 weeks ago
$117K - $161K *
Shape the future of Quality Engineering by leading portfolio management, financial governance, and strategic execution. Collaborate across teams to enhance operational effectiveness and drive transfor...
Reposted 2 weeks ago
Senior Analyst, Business Operations & Strategy
$111K - $167K *
Optimize the customer journey by leveraging analytics and strategic insights to enhance pipeline generation, forecasting, and sales enablement for a growing Property Care business. Collaborate cross-f...
Yesterday
Medical Director, Utilization Management
$180K - $220K *
Lead the evaluation of outpatient referrals and inpatient admissions for medical necessity, utilizing guidelines and criteria to ensure quality care. Collaborate with providers and mentor UM nurses to...
Reposted today
$110K - $149K *
Unlock potential by leading healthcare data analytics to enhance hospital quality performance and rankings. Collaborate with teams to design dashboards, mentor analysts, and present insights to execut...
2 weeks ago
Senior Director, Strategic Accounts
$140K - $190K *
Empower our sales team by driving strategic growth in key accounts. Leverage your expertise in Enterprise SaaS to navigate complex sales in the Life Sciences sector, fostering partnerships and deliver...
3 weeks ago
Data Integration Administrator, TPA
$74K - $115K *
Join a dynamic team to develop and support SQL-based ETL processes, ensuring data quality and integration performance across business applications. Collaborate with technical teams to enhance data exc...
3 weeks ago
Senior Director, Analytical Development
$230K - $280K *
Champion analytical development by leading strategy and execution for pipeline products. Drive compliance and quality control while building a high-performing team in a dynamic environment focused on...
Today
Staff Software Development Engineer - Data Analytics
$106K - $213K *
Elevate digital engineering by designing and implementing scalable software solutions, collaborating with cross-functional teams, and driving innovation in data analytics projects to meet business obj...
Reposted 3 days ago
Director of Consultant Relations
$110K - $130K *
Unlock potential by cultivating strategic relationships with benefits consultants and brokers. Drive revenue growth through effective partnerships, collaboration with cross-functional teams, and exper...
3 weeks ago
Security & Infrastructure Engineer
$100K - $120K *
Drive security excellence by managing identity access, external testing, and compliance processes. Collaborate with teams to enhance AWS security and develop scalable policies, ensuring robust protect...
3 weeks ago
$104K - $156K *
Lead the design, development, and integration of AI applications that enhance business operations. Collaborate with cross-functional teams to deliver technical solutions while maintaining security, re...
Reposted today
Quality Analyst - Clinical Validation Audit
$85K - $100K *
Elevate quality assurance in clinical audits by applying expert judgment and mentoring auditors. Ensure accuracy in DRG coding through comprehensive reviews and trend analysis, while fostering a colla...
1 month ago
Provider Clinical Operations Consultant, Senior Associate
$77K - $202K *
Drive clinical operations modernization for healthcare providers, enhancing efficiency and service delivery. Analyze complex challenges, mentor junior staff, and foster client relationships while navi...
Today
$102K - $179K *
Unlock potential by designing and developing innovative software solutions that drive business objectives. Collaborate with cross-functional teams to tackle complex challenges and mentor engineers in...
4 weeks ago
Sr. Director, Industry and Payor Strategy
$174K - $217K *
Drive strategic leadership in industry partnerships and payor strategy, enhancing market access and competitive positioning. Lead a high-performing team to execute a multiyear plan that fosters sustai...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.