Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$136K - $187K *
Unlock potential by serving as a vital resource for patients and caregivers, providing education and support for managing generalized Myasthenia Gravis while coordinating treatment and navigating insu...
1 week ago
Emergency Medicine Physician (AI Clinical Evaluation)
$210K - $250K *
Transform your expertise in Emergency Medicine by developing high-fidelity clinical scenarios and evaluating AI outputs to enhance patient safety and decision-making in a remote, flexible role...
3 days ago
Financial & Budget Management Analyst - Senior
$142K - $171K *
Elevate financial management practices and provide expert analysis, supporting program budgets and resource allocation with strategic insights and effective communication to key stakeholders in a comp...
Reposted today
Director, Advanced Analytics and Data Science - Innovation
$174K - $234K *
Shape the future of advanced analytics and AI, driving data-driven solutions across commercial, medical, and clinical operations. Collaborate cross-functionally to deliver insights, enhance decision-m...
Reposted 3 weeks ago
$95K - $130K *
Lead the charge in backlog management and agile ceremonies, translating stakeholder needs into prioritized tasks. Collaborate across squads to ensure delivery quality and stakeholder satisfaction whil...
1 week ago
Sr Manager Financial Planning and Analysis
$125K - $150K *
Lead the Corporate FP&A function, overseeing forecast consolidation, monthly reporting, and financial analysis. Collaborate with finance and business partners to ensure accuracy and transparency in fi...
3 weeks ago
$131K - $200K *
Join a team that's shaping the future of data platforms by developing scalable solutions for analytics and AI workloads. Collaborate on impactful projects using cutting-edge tools to enhance data reli...
1 week ago
Senior EHR Data Integration Consultant - Remote, US
$123K - $169K *
Elevate healthcare data integration by leading client engagements, optimizing EHR extracts, and providing strategic guidance. Utilize your SQL expertise to ensure data accuracy and foster strong clien...
6 days ago
$105K - $202K *
Innovate and build AI-native products that automate complex workflows. Collaborate with cross-functional teams to design, develop, and deploy full-stack applications, ensuring reliability and performa...
3 weeks ago
$90K - $100K *
Join a team that's dedicated to optimizing payroll operations and compliance. This role supports payroll processing, reporting, and employee services, ensuring accuracy and scalability as the organiza...
6 days ago
Senior Director, Third Party Risk Management
$134K - $249K *
Unlock potential by leading enterprise-wide third party risk management, ensuring compliance and oversight across healthcare functions. Drive strategic direction, governance, and risk frameworks while...
Today
$99K - $165K *
Champion the future of executive talent acquisition by leveraging market insights, building diverse talent pipelines, and collaborating with senior leaders to enhance the recruiting brand and drive st...
3 weeks ago
$120K - $160K *
Analyze complex operational data to drive insights and improve customer outcomes. Collaborate with cross-functional teams, lead impactful analyses, and create self-service analytics tools to enhance d...
1 week ago
Oak Street Health New Graduate Nurse Practitioner Fellowship
$100K *
Contribute to innovative adult primary care through a 12-month fellowship, gaining hands-on experience and mentorship while building your patient panel in a supportive, collaborative environment focus...
2 weeks ago
Senior Market Research Analyst - International Development & AI
$70K - $95K *
Join a team that's shaping the future of AI in international development. Lead market research initiatives to identify opportunities, analyze trends, and provide strategic insights that drive business...
3 days ago
National Client Executive Central Region
$94K - $125K *
Lead the charge in enhancing client relationships and driving growth for national clients. Manage a team to deliver exceptional service, develop strategic initiatives, and ensure client satisfaction w...
6 days ago
Senior Engineer, Data Engineering
$144K - $165K *
Unlock potential by owning data architecture and reliability across domains. Collaborate with an AI-first team to design robust data pipelines, enhance analytics, and drive impactful solutions in a dy...
1 week ago
$130K - $160K *
Transform financial strategies by leveraging your expertise in analyses, forecasting, and IT governance. Drive impactful recommendations and enhance operational efficiency through innovative financial...
Reposted 1 week ago
$146K - $189K *
Partner with us to enhance our community health provider network. Leverage your expertise in provider relations and network management to drive growth, improve access to care, and support our mission...
3 weeks ago
Internal Audit - Technology Audit & Analytics Advisor - Hybrid
$102K - $170K *
Join a team that's transforming Internal Audit through data analytics and technology. Contribute to innovative audit techniques while collaborating with stakeholders to enhance audit effectiveness and...
Today
$80K - $110K *
Transform your career by developing innovative software solutions in a collaborative Agile environment. Engage in all phases of the software development lifecycle while enhancing cybersecurity and ide...
Reposted 5 days ago
Advanced Practice Provider (NP/PA/CNS) – Independence Internal Medicine I
$90K - $110K *
Deliver comprehensive primary and specialty care as an Advanced Practice Provider, collaborating with a healthcare team to enhance patient outcomes. Emphasize health promotion and disease prevention w...
4 days ago
Pharmacist Clinical Specialist - Institutional
$110K - $130K *
Execute impactful pharmaceutical care by optimizing drug therapy and enhancing patient outcomes. Collaborate with healthcare teams to ensure safe medication practices while educating staff and fosteri...
6 days ago
Pharmacist Clinical Specialist - Institutional
$110K - $130K *
Unlock potential by providing expert pharmaceutical care in a dynamic environment. Collaborate with healthcare teams to enhance patient outcomes through effective drug therapy management and education...
6 days ago
$108K - $130K *
Drive program delivery across multiple products, ensuring timely outcomes by managing risks, dependencies, and stakeholder priorities. Collaborate cross-functionally to maintain accurate project data...
4 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.