Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$83K - $117K *
Empower business growth by leading experimentation strategies and analytical initiatives. Utilize advanced statistical techniques to analyze complex datasets, influence decision-making, and drive impa...
Yesterday
Staff Engineer, Detection and Response
$225K - $281K *
Lead the charge in shaping detection and response strategies, driving hands-on initiatives to enhance security architecture and incident management. Collaborate across teams to ensure robust threat de...
2 weeks ago
Executive Director, Health Economics & Outcomes Research (HEOR)
$246K - $332K *
Shape the future of health economics and outcomes research by leading strategic initiatives across the nephrology portfolio, ensuring high-quality evidence generation and collaboration with cross-func...
2 weeks ago
Sr. Data Analyst, Customer Analytics (Insurance)
$84K - $120K *
Accelerate insights generation as a key member of the Customer Analytics team, transforming raw data into actionable recommendations that enhance client retention, drive growth, and refine operational...
Reposted 3 weeks ago
$95K - $115K *
Unlock potential by driving data-driven insights to enhance revenue and operational performance. Collaborate with cross-functional teams to transform complex data into actionable recommendations that...
Reposted 1 week ago
$86K - $107K *
Lead advanced analytics projects that drive strategic decisions, optimize sales productivity, and enhance operational efficiency. Collaborate with executives to deliver data-driven insights and implem...
3 days ago
Internal Medicine Nurse Practitioner
$95K - $115K *
Join a team that's dedicated to enhancing patient care through internal medicine. You'll leverage your expertise while working full-time, impacting lives in a leading acute-care hospital within a supp...
Reposted today
Lead Healthcare Services Software Engineer
$110K - $130K *
Unlock innovation by designing, developing, and maintaining software systems. Collaborate with stakeholders to analyze requirements and ensure solutions meet business needs while providing technical e...
2 weeks ago
$102K - $184K *
Elevate your career by leading market-level financial reporting and performance management in value-based healthcare. Collaborate with stakeholders to drive insights and outcomes, ensuring disciplined...
1 week ago
$130K - $155K *
Join a team that's dedicated to driving operational excellence and project delivery. Lead a diverse portfolio, enhance agency workflows, and foster collaborative relationships across departments to en...
4 days ago
$80K - $95K *
Champion cross-functional projects to enhance operational efficiency and achieve organizational goals. Lead initiatives from planning to completion, ensuring timely delivery within scope and budget wh...
5 days ago
Healthcare Business Banking Relationship Manager - MO/AR
$118K - $144K *
Lead the charge in driving growth for healthcare clients by managing complex financial relationships, structuring credit solutions, and delivering integrated financial strategies that enhance client s...
Reposted 2 days ago
Healthcare Business Banking Relationship Manager - MO/AR
$118K - $144K *
Join a team that's dedicated to empowering healthcare clients by managing complex financial relationships, driving growth, and delivering tailored solutions while navigating industry challenges and ma...
Reposted 2 days ago
Healthcare Business Banking Relationship Manager - MO/AR
$118K - $144K *
Join a team that drives growth and builds relationships in the healthcare sector. In this role, you will advise clients, navigate complex credit structures, and craft integrated financial solutions, a...
Reposted 2 days ago
$245K - $270K *
Elevate patient care by providing value-based healthcare to Medicare populations. Collaborate with a dedicated team to enhance quality outcomes and ensure a superior patient experience in a supportive...
3 weeks ago
$180K - $220K *
Unlock your potential by driving enterprise growth in healthcare. Join a dynamic team focused on building relationships with health systems and provider organizations, leveraging a robust support engi...
2 weeks ago
Account Executive Healthcare Customer Base
$100K - $120K *
Drive enterprise-level revenue growth by building relationships with healthcare executives, identifying strategic opportunities, and delivering tailored solutions to meet sales goals in a dynamic heal...
6 days ago
$80K - $95K *
Join a team that's redefining inpatient coding operations, ensuring quality and compliance while optimizing workflows. Lead a dedicated team to enhance documentation practices and support financial he...
2 weeks ago
Senior Data Engineer (Analytics & Applied AI)
$113K - $188K *
Lead the charge in building robust data platforms that transform complex datasets into actionable insights. This senior role demands expertise in software and data engineering, with a focus on quality...
1 week ago
Client Growth & Success, Senior Manager- Enterprise Accounts
$130K - $145K *
Champion client success by managing strategic partnerships with mid-sized enterprises. Drive measurable outcomes through relationship management, consultative problem-solving, and cross-functional col...
2 weeks ago
Sr. Analyst, Pricing Analytics
$89K - $134K *
Explore your potential as a key analytical consultant, leveraging data to optimize drug pricing and enhance pharmacy relationships while collaborating across multiple functions to drive strategic grow...
1 week ago
$100K - $125K *
Join our dynamic finance team as you drive margin and profitability through detailed analysis and strategic insights. Collaborate with senior leadership to transform data into actionable initiatives t...
2 weeks ago
Test Lead II - Healthcare Payer Testing
$90K - $120K *
Champion quality assurance in healthcare payer systems by leading test planning, execution, and defect management. Collaborate with cross-functional teams to ensure compliance and deliver high-quality...
2 weeks ago
$130K - $155K *
Unlock your potential by owning the technical design of a comprehensive data platform. Collaborate with cross-functional teams to deliver trustworthy data solutions that enhance product performance an...
6 days ago
Software Engineer/Sr Software Engineer
$120K - $170K *
Develop and enhance Python services for pharmacy claims processing. Collaborate across teams to deliver high-quality solutions while gaining expertise in the pharmacy benefits domain. Embrace a hybrid...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.