Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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Healthcare Analyst Jobs in Missouri

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$121K - $161K *

Transform your career by leading the design and implementation of Veeva Vault RIM, ensuring optimal performance and compliance while collaborating with cross-functional teams to enhance user experienc...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$58K - $105K *

Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $153K *

Drive your career forward as a Senior ServiceNow Administrator, overseeing platform health, production support, and complex solution design. Collaborate with teams to enhance automation, integrations...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $160K *

Transform AI analytics by executing measurement frameworks and optimizing performance across voice and chat channels. Collaborate with cross-functional teams to deliver actionable insights and enhance...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $160K *

Join a team that's transforming healthcare with AI solutions. As an AI Solutions Engineer, you'll develop integrations and tools that enhance customer workflows, bridging the gap between clients and o...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $105K *

Drive clinical excellence by leading documentation quality and process improvement initiatives. Collaborate with teams to enhance education, compliance, and patient safety, ensuring optimal clinical d...

Missouri, USRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate financial analysis by leading evaluations of distressed debt portfolios, managing due diligence, and assessing creditworthiness. Collaborate across teams to optimize asset recovery and deliver...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Business Services

$83K - $114K *

Unlock potential by driving regulatory compliance and optimizing trade processes. Collaborate with diverse teams to ensure accurate tariff classifications and effective communication with stakeholders...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $114K *

Analyze and optimize tariff classification processes while ensuring compliance with government regulations. Collaborate with diverse teams to enhance decision-making and drive business effectiveness t...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$59K - $101K *

Elevate your career by contributing to innovative software solutions, collaborating with cross-functional teams to develop secure, user-centered applications while enhancing your engineering skills th...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $170K *

Design innovative AI solutions on Microsoft Azure, bridging business needs and engineering execution. Own the architecture, ensure security, and lead the build process while adapting to evolving proje...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$87K - $157K *

Shape the future of healthcare quality reporting by leading complex, cross-functional projects. Drive strategic initiatives, enhance operational processes, and ensure accountability while collaboratin...

Missouri, USRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Drive impactful analytics by designing and maintaining Power BI dashboards, leveraging SQL expertise to extract insights from complex datasets, and applying insurance knowledge to enhance reporting so...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$108K - $156K *

Empower your career by leading revenue analytics, overseeing financial analysis, and enhancing payer contract strategies. Collaborate with cross-functional teams to optimize reimbursement and drive or...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $130K *

Lead the administration and enhancement of the ServiceNow platform, ensuring optimal service delivery and user experience. Collaborate with teams to support ITSM processes and drive continuous improve...

Missouri, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$124K - $280K *

Unlock the potential of AI in healthcare by leading innovative solutions that enhance clinical decision-making, operational efficiency, and population health. Drive impactful projects while managing g...

2 weeks ago

  •   11 - 15 years exp.  •   Legal & Accounting

$88K - $138K *

Drive cross-functional projects by translating business needs into technical requirements, ensuring successful adoption of solutions across various People Technology platforms, including Workday and T...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$70K - $110K *

Unlock your potential by analyzing data and conducting audits to enhance compliance for innovative B2B and B2C platforms. Collaborate with cross-functional teams, apply critical thinking, and gain ins...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Drive budget management and project support for public health initiatives, ensuring accurate tracking, analysis, and reporting. Collaborate with leadership to enhance operational efficiency in a dynam...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$83K - $107K *

Shape the future of clinical education by leading Epic EMR training initiatives. Collaborate with healthcare professionals to enhance patient care through effective training programs, ensuring optimal...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $205K *

Champion complex digital forensic investigations and tool development, leveraging AI to enhance workflows. Collaborate with clients and teams to deliver actionable insights and scalable solutions acro...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Lead the future of patient experience by driving strategic initiatives and operational excellence in a high-volume healthcare contact center. Collaborate with cross-functional teams to enhance service...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $144K *

Optimize our data platform by owning end-to-end data engineering projects, leveraging AI coding agents, and ensuring data quality. Collaborate with cross-functional teams to deliver reliable, maintain...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $150K *

Champion growth by building strategic relationships and driving sales in the Healthcare sector. Leverage AI solutions to enhance customer engagement and achieve revenue targets while collaborating wit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $115K *

Transform federal human capital management by leveraging your HR expertise. Collaborate with a high-performing team to enhance service delivery and drive continuous improvement in HR processes and sys...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.