Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Business Development Manager - Acute
$95K - $115K *
Grow your career by driving revenue growth in the acute care market through new customer acquisition and account expansion. Manage the full sales lifecycle while collaborating with internal teams to d...
6 days ago
$153K - $207K *
Lead impactful initiatives in healthcare fraud analysis, driving data-driven solutions and collaborating with cross-functional teams to enhance Medicaid and Medicare outcomes while presenting findings...
3 days ago
Account Director - Oncology Provider
$219K - $277K *
Elevate community oncology practices by driving growth and retention through strategic sales initiatives. Collaborate with cross-functional teams to enhance market presence and deliver tailored soluti...
5 days ago
Senior Principal, Business Management
$135K - $160K *
Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...
Reposted 2 days ago
Home Health Strategy Advancement Advisor
$104K - $143K *
Empower healthcare transformation by developing strategic initiatives that enhance operational efficiency and clinician productivity. Collaborate cross-functionally to drive impactful solutions and im...
1 week ago
VP, Data Strategy & Governance
$175K - $210K *
Drive the enterprise data strategy and governance, ensuring data quality, compliance, and accessibility. Lead cross-functional teams to foster a data-rich culture, enabling advanced analytics and AI r...
Reposted today
$110K - $130K *
Unlock your potential as a senior Epic Willow Analyst, leading pharmacy workflow configurations and supporting clinical applications in a dynamic healthcare environment. Collaborate with teams to opti...
6 days ago
$111K - $167K *
Empower your career by leading IT systems development, implementation, and maintenance. Oversee complex networks, ensure security, and drive automation, all while collaborating to enhance operational...
Reposted 3 weeks ago
$130K - $185K *
Unlock insights at scale by transforming complex healthcare data into actionable analytics solutions. Collaborate with cross-functional teams to design and optimize data models, ensuring high-quality...
Today
Senior VA Health Systems Integration & Interoperability Specialist
$125K - $200K *
Drive VA health systems integration by leading complex interoperability initiatives, ensuring seamless data flow across clinical and community care platforms to enhance Veteran care and operational ef...
2 days ago
Lead Change, Release and Deployment Analyst
$102K - $190K *
Elevate change management processes by leading operational execution and quality assurance. Oversee complex change reviews, coach teams, and ensure compliance with governance standards while enhancing...
Today
$110K - $130K *
Empower data-driven decisions by designing and optimizing complex data pipelines. Collaborate with cross-functional teams to ensure scalable, high-quality data solutions that enhance analytics and rep...
4 days ago
Data Analytics Manager - Client Legal Services
$100K - $170K *
Drive the evolution of Legal Operations analytics by building scalable data capabilities, modernizing reporting, integrating AI, and establishing predictive models to enhance decision-making and opera...
Reposted 1 week ago
Director, CMS & HHS Business Development
$182K - $250K *
Champion market development strategies to enhance our presence in CMS and HHS. Leverage your expertise to build relationships, identify opportunities, and drive impactful outcomes in federal health IT...
Reposted today
Lead AI and Data Solution Engineer
$200K - $215K *
Drive the design and deployment of innovative data and AI solutions, leveraging expertise in LLMs, agentic AI, and cloud technologies to enhance business value and ensure compliance with industry stan...
3 weeks ago
Data & Statistical Reporting Analyst
$72K - $100K *
Unlock potential by analyzing and interpreting data to drive business insights. Collaborate with cross-functional teams to manage statistical reporting, ensuring compliance and data quality while adap...
4 days ago
$100K - $120K *
Join a team that analyzes credit policies and develops strategies to enhance lending effectiveness, utilizes data analytics for risk management, and collaborates with stakeholders to drive impactful d...
Reposted 3 weeks ago
Workday Healthcare Financial Implementation Consultant
$140K - $210K *
Partner with us to drive innovative financial solutions in the healthcare sector. Leverage your Workday expertise for impactful implementations, collaborating closely with teams to transform operation...
Reposted 1 week ago
$80K - $95K *
Engage with healthcare providers and patients to enhance clinical education, improve patient outcomes, and deliver essential support services. Collaborate with partners to strategize educational oppor...
3 weeks ago
$80K - $95K *
Partner with us to enhance patient education and support healthcare providers, leveraging your clinical expertise to improve outcomes through effective training and collaboration within the healthcare...
3 weeks ago
Senior Manager, Third Party Data Governance
$120K - $145K *
Shape the future of data governance by leading a team to manage third-party data compliance, ensuring operational excellence and regulatory adherence while fostering collaboration across business unit...
6 days ago
$160K - $200K *
Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...
6 days ago
Senior ITCR / Requirements Analyst
$79K - $122K *
Shape the future of IT capabilities by leading requirements analysis and advisory support for a Department of War agency. Collaborate with stakeholders to deliver data-driven insights and enhance ente...
1 week ago
$96K - $111K *
Drive the administration and analysis of employee benefits programs, ensuring compliance and enhancing the associate experience. Collaborate with HR and external vendors to manage health, retirement...
Today
Executive Director, Financial Planning & Commercial Growth
$175K - $210K *
Join a team that's shaping the future of innovation in cancer research by leading financial planning and commercialization efforts to support strategic growth and decision-making across an impactful o...
Reposted 2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.