Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$85K *

Champion quality assurance by developing and executing test strategies to ensure technology solutions meet business and user requirements. Collaborate with cross-functional teams to enhance applicatio...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Drive regulatory strategy across major programs, leading high-impact submissions and authority engagement. Collaborate with cross-functional teams to optimize clinical development and ensure complianc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $120K *

Elevate client relationships by managing healthcare accounts, leveraging product knowledge, and driving adoption of solutions to enhance outcomes and satisfaction. Collaborate with teams to address cl...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $97K *

Bring your expertise to a collaborative team driving strategic pricing. You'll create competitive pricing strategies, analyze market trends, support sales efforts, and develop financial models to enha...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $155K *

Champion product innovation by managing software initiatives that enhance internal communication and streamline operations. Collaborate with cross-functional teams to deliver impactful solutions and d...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Staffing

$95K - $115K *

Shape your career with a key role ensuring compliance and validation of GxP computerized systems, enhancing product quality and data integrity through risk-based assessments and regulatory adherence a...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$79K - $115K *

Lead the charge in developing strategic executive compensation programs that attract top talent and ensure market competitiveness. Collaborate with HR, Finance, and leadership to analyze trends, desig...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$79K - $115K *

Unlock potential by serving as a strategic compensation resource, collaborating with HR and leadership to design and implement executive compensation programs that attract top talent and ensure market...

Somerville, MARemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$74K - $147K *

Engage in innovative actuarial analyses and support AI-driven solutions to enhance client operations. Collaborate on modernization projects and develop financial models to drive strategic decision-mak...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$86K - $130K *

Join a team that's dedicated to guiding patients through their care journey. As a Nurse Case Manager, you'll assess needs, coordinate care, and support transitions, ensuring optimal patient outcomes a...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$162K - $222K *

Unlock potential by leading insights for key assets, driving strategic decisions through market research and analytics. Collaborate cross-functionally to translate complex data into actionable narrati...

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$60K - $129K *

Join a team that's dedicated to enhancing member care through comprehensive assessments, crisis intervention, and collaborative planning. Utilize your clinical expertise to support optimal health outc...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$109K - $174K *

Drive innovation in medical imaging AI to enhance oncology clinical decisions. Collaborate across teams to develop quantitative metrics and insights, transforming trial data into impactful clinical ap...

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$94K - $164K *

Champion operational excellence by leading business analysis initiatives, driving process improvements, and aligning solutions with strategic goals to enhance efficiency and effectiveness across the o...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $113K *

Grow your career with a dynamic role guiding patients through the care continuum. Collaborate with healthcare teams to assess needs, coordinate care, and support patient education, ensuring optimal he...

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$86K - $130K *

Empower patients by guiding them through the care continuum, assessing needs, coordinating care, and managing outpatient services. Collaborate with a dedicated team to enhance patient health and indep...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Drive the transformation of clinical data management by leading the data engineering function, mentoring a team, and building scalable data pipelines that empower AI-driven products and clinical resea...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Staffing

$110K - $130K *

Drive analytics initiatives that connect Paid Media performance to full-funnel outcomes. Collaborate with cross-functional teams to design measurement frameworks, optimize data models, and provide act...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Analyze and evaluate AI-generated chatbot responses to enhance accuracy and relevance. Collaborate with stakeholders to document requirements and deliver structured assessments that drive improvements...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Staffing

$110K - $130K *

Lead the charge in managing informatics projects from planning to delivery, ensuring timely decision-making and risk management. Collaborate with cross-functional teams to enhance health information e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$96K *

Join a dynamic Finance team as a Financial Analyst, focusing on sales commissions and SaaS metrics. Collaborate across departments to ensure accurate financial reporting and drive insights that suppor...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$70K - $100K *

Join a team that's dedicated to optimizing Epic Resolute Professional Billing. Support daily operations, troubleshoot issues, and enhance workflows while collaborating with analysts and users to ensur...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Shape the future of healthcare by owning and optimizing AI systems. Design and deliver scalable ML solutions that transform operations, enhance decision-making, and create real-world impact across cri...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $195K *

Drive enterprise sales success by engaging CIOs and CTOs, leading complex sales cycles, and connecting technology strategies to measurable business outcomes. Collaborate with cross-functional teams to...

4 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $145K *

Champion innovative solutions as a Senior Business Analyst, driving requirements gathering and Agile processes to enhance custom applications for DHS. Collaborate with teams to streamline operations a...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.