Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$97K - $125K *

Drive impactful change by analyzing user needs and defining requirements for clinical applications. Collaborate with diverse teams to enhance electronic health record systems, ensuring effective docum...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$174K - $374K *

Lead the charge in clinical oversight and mentorship, driving innovative medical solutions across diverse programs. Collaborate with cross-functional teams to ensure evidence-based decision-making and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $155K *

Empower financial transformation with post-merger integration strategies. Collaborate with clients to enhance accounting processes and optimize integration initiatives for growth-focused businesses af...

4 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$122K - $176K *

Elevate bioanalytical and biomarker operations by managing outsourcing efforts, ensuring quality deliverables, and collaborating with stakeholders throughout clinical and preclinical studies for impac...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Advance business processes by analyzing requirements and defining system objectives. Collaborate with IT to enhance applications and support testing efforts for small to moderate projects, ensuring al...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Innovate business processes by analyzing requirements and defining system objectives. Collaborate across IT to enhance applications and support testing efforts, ensuring effective solutions for small...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$87K - $153K *

Unlock potential by assessing and optimizing AWS environments, identifying gaps, and recommending architecture improvements. Collaborate with technical stakeholders to enhance cloud infrastructure and...

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Empower nursing excellence by designing and implementing comprehensive education programs across diverse clinical areas, enhancing professional development through collaboration and innovative teachin...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Champion seamless communication by managing VoIP and telephony systems, ensuring optimal performance and user satisfaction. Collaborate across departments to analyze data, enhance workflows, and uphol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $112K *

Support large-scale research initiatives by managing operations, budgets, and partnerships. Oversee project teams, ensure compliance, and contribute to data analysis and publications, driving innovati...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$61K - $98K *

Transform the landscape of risk management by overseeing collections and funding returns, analyzing transaction patterns, and collaborating with teams to resolve complex cases while driving process im...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the charge in providing information assurance support to ensure security compliance for systems at Hanscom AFB, managing risks and aiding in certification processes to safeguard vital data and in...

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $145K *

Accelerate progress at a crucial leadership role shaping enterprise data strategies. Collaborate with global teams to define roadmaps that turn fragmented data into strategic insights for R&D, Medical...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

The Director of Government Reimbursement will serve in a consultancy capacity, advising large health systems on managing and optimizing healthcare reimbursement processes, particularly focusing on Med...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$130K - $178K *

Transform procurement strategies by leading complex sourcing initiatives, collaborating with cross-functional teams, and driving cost-effective solutions to enhance operational efficiency and supplier...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $185K *

Transform data into actionable insights by enhancing financial models, optimizing sales performance, and driving operational efficiencies. Collaborate with cross-functional teams to support strategic...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $120K *

Join a team that's dedicated to enhancing clinical operations through strategic site identification and management. Leverage your expertise to build relationships, track project timelines, and contrib...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$73K - $125K *

Unlock potential by conducting in-depth policy analysis and quantitative research to support environmental and public health initiatives. Collaborate with multidisciplinary teams to inform regulatory...

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$73K - $125K *

Empower your career by providing critical analysis and consulting for environmental and public health programs. Collaborate with multidisciplinary teams to develop evidence-based solutions and support...

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Drive provider network excellence by managing data integrity, overseeing contract configurations, and leading cross-functional teams to enhance operational efficiency and compliance in a dynamic TPA e...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Champion innovative solutions as a Business Solutions Analyst, collaborating with healthcare organizations to drive strategic initiatives and operational excellence across diverse projects and deliver...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Empower healthcare IT delivery by managing a dynamic team, ensuring operational excellence, and driving EMR performance. Collaborate with clinical stakeholders to enhance patient care through effectiv...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $95K *

Shape the future of clinical research data integrity by leading a dedicated team. Drive operational excellence, ensure compliance, and foster cross-functional partnerships to enhance data quality and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Help us shape the future of our operations by designing AI-enabled processes. Collaborate with cross-functional teams to map current workflows, identify automation opportunities, and drive transformat...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Drive AI transformation by mapping current processes and designing future-state models across G&A functions. Collaborate with stakeholders to identify automation opportunities and enhance operational...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.