Explore $100K+ Jobs in Kentucky

Discover high-paying professional opportunities across Kentucky with Ladders. Browse vetted roles with salaries of $100,000 or more, from established employers and growing organizations. Whether you’re interested in positions in Louisville, Lexington, Bowling Green, or elsewhere in the state, find opportunities that fit your experience and career goals.

Professional Opportunities Across Kentucky

Kentucky’s economy spans healthcare, manufacturing, logistics, finance, technology, education, and other industries. Employers across the state seek experienced professionals for roles in leadership, operations, engineering, sales, healthcare administration, and more. The right opportunity may be available in a major metro area or in a smaller community.

Find a Role That Fits Your Experience

Use Ladders to explore opportunities suited to your skills, seniority, and compensation expectations. Review job descriptions, compare responsibilities, and identify roles where your professional background can make an impact. Listings on Ladders are vetted and pay at least $100,000.

Advance Your Career in Kentucky

Build your next career move by searching Kentucky jobs and narrowing results by location, industry, and role. Check listings regularly, tailor your resume to each opportunity, and highlight measurable accomplishments that demonstrate your value to prospective employers.

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$208K - $220K *

Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Lead the charge in overseeing complex clinical trials, ensuring timely execution and adherence to budget. Drive collaboration across teams while maintaining high standards for project delivery and sta...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$168K - $283K *

Lead the charge in advancing early-stage clinical trials for innovative Orexin-targeted therapies. Collaborate cross-functionally to shape scientific strategy, drive execution, and ensure high-quality...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$153K - $268K *

Transform clinical science in late-stage trials for innovative sleep/wake therapies. Collaborate cross-functionally to ensure compliance, drive recruitment, and deliver high-quality results while shap...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$101K - $146K *

Unlock potential by leading payer contract negotiations to enhance relationships, optimize revenue, and ensure compliance with regulations, all while aligning with strategic priorities of the health s...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $170K *

Lead the charge in transformative project management, driving cross-functional teams to execute multichannel initiatives successfully. Cultivate client relationships, ensure project delivery on-time...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$149K - $298K *

Lead strategic and operational initiatives for field clinical teams, ensuring compliance and effective trial support for TMVR programs while driving positive patient outcomes and team performance...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $138K *

Drive independent assessments of deployment readiness across workstreams, ensuring quality and compliance. Collaborate with teams to produce readiness evaluations and present findings to leadership, e...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Aerospace & Defense

$125K - $155K *

Champion strategic initiatives by connecting breakthrough chemistry with market opportunities. Collaborate across teams to drive government partnerships, proposals, and commercial growth, transforming...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$227K - $313K *

Elevate your career by leading strategic reimbursement initiatives, optimizing revenue cycles, and collaborating with key stakeholders to enhance patient access and billing processes in a dynamic heal...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$100K - $120K *

Lead the charge in transforming IT support for healthcare centers by evaluating, planning, and executing transitions to AMSURG Managed IT Services, while architecting cloud solutions with Microsoft 36...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$113K - $197K *

Drive optimal enrollment operations through strategic leadership, overseeing member lifecycle processes, compliance, and data integrity while managing vendor partnerships and operational transformatio...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Join a team that's dedicated to providing exceptional orthopedic care. As a Family Nurse Practitioner or Physician Assistant, you'll play a vital role in patient management, collaborating with healthc...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Partner with us to lead transformative business development initiatives in life sciences. Drive revenue through strategic engagement with pharma/biotech partners, managing the full sales cycle and ens...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $138K *

Unlock your potential by joining a dynamic team focused on delivering top-notch Ultrasound IT support. Collaborate with customers to resolve complex technical issues in a fast-paced environment, ensur...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$165K - $175K *

Empower progress at the forefront of data product management, leading the development of innovative solutions. Drive product success through strategic oversight, client engagement, and cross-functiona...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$144K - $245K *

Lead the design and execution of workforce development programs, ensuring compliance and timely deliverables. Collaborate across teams and stakeholders to create scalable systems that enhance healthca...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$106K - $284K *

Lead application development initiatives, ensuring quality standards in healthcare IT. Collaborate with diverse teams to define requirements and implement solutions that profoundly impact patient care...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$117K - $195K *

Champion the development and execution of data stewardship training programs to enhance organizational data quality and governance skills while collaborating with domain experts to address skill gaps...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$112K - $149K *

Drive innovation by building and maintaining data pipelines and governance policies in a hybrid cloud environment. Collaborate with a small team to ensure reliable data flow and access control, enhanc...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $145K *

Optimize data center financial operations, analyzing performance, driving cost savings, and supporting strategic initiatives while ensuring efficient management of the data center portfolio through ro...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Join a team that's dedicated to enhancing ERP solutions for colleges and universities. As a consultant, you'll collaborate on Ellucian Banner implementations, ensuring client needs are met within scop...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$106K - $141K *

Join a team that's building an AI-ready data foundation for marketing and GTM. You'll design, govern, and analyze data models, ensuring reliable insights for strategic decision-making across the organ...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $154K *

Drive your career by developing integrated power conversion solutions for diverse industries. Leverage your technical expertise to create innovative applications and enhance business opportunities in...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$105K - $202K *

Engineer robust data platforms by designing scalable pipelines and APIs that support AI-driven healthcare applications, ensuring high performance, security, and operational excellence in a collaborati...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Kentucky?question toggle

    Kentucky listings may include senior and experienced roles in areas such as healthcare, manufacturing, logistics, finance, technology, sales, engineering, and operations. Available positions vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Opportunities may be found in Louisville, Lexington, Bowling Green, and communities throughout the state. Search by location to explore current openings near you.

  • Do jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with advertised salaries of $100,000 or more. Review each listing for its specific compensation details and requirements.

  • How can I find a high-paying job in Kentucky?question toggle

    Search Kentucky listings by city, role, or industry, then review the qualifications and compensation details. Tailor your resume to the position and emphasize relevant accomplishments and leadership experience.