Explore $100K+ Jobs in Kentucky

Discover high-paying professional opportunities across Kentucky with Ladders. Browse vetted roles with salaries of $100,000 or more, from established employers and growing organizations. Whether you’re interested in positions in Louisville, Lexington, Bowling Green, or elsewhere in the state, find opportunities that fit your experience and career goals.

Professional Opportunities Across Kentucky

Kentucky’s economy spans healthcare, manufacturing, logistics, finance, technology, education, and other industries. Employers across the state seek experienced professionals for roles in leadership, operations, engineering, sales, healthcare administration, and more. The right opportunity may be available in a major metro area or in a smaller community.

Find a Role That Fits Your Experience

Use Ladders to explore opportunities suited to your skills, seniority, and compensation expectations. Review job descriptions, compare responsibilities, and identify roles where your professional background can make an impact. Listings on Ladders are vetted and pay at least $100,000.

Advance Your Career in Kentucky

Build your next career move by searching Kentucky jobs and narrowing results by location, industry, and role. Check listings regularly, tailor your resume to each opportunity, and highlight measurable accomplishments that demonstrate your value to prospective employers.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$98K - $160K *

Shape the future of clinical research by implementing innovative digital tools and technologies. Collaborate with cross-functional teams to ensure compliance and quality in study delivery while managi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $160K *

Elevate your career as a Staff Software Engineer, leading full-stack development in a dynamic team. Design, build, and support healthcare applications while ensuring data security and compliance in a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Transform patient care by conducting assessments, implementing interventions, and collaborating with interdisciplinary teams to enhance health outcomes while ensuring compliance with policies and regu...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$94K - $130K *

Drive operational excellence by coordinating cross-functional processes, ensuring governance, and optimizing workflows to enhance efficiency and stakeholder experience across the enterprise...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Join a team that's shaping the future of AI by designing and implementing enterprise-grade solutions on Google Cloud and Azure, focusing on data migration, pipeline development, and robust cloud infra...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$74K - $116K *

Join a team that's optimizing omnichannel marketing campaigns and enhancing lead generation. Collaborate with cross-functional teams to analyze performance, drive insights, and improve customer engage...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $143K *

Contribute to sales and marketing initiatives in a designated territory, driving revenue growth and managing customer relationships. Develop strategic plans, assess opportunities, and collaborate with...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Pioneer advancements in physics by conducting cutting-edge research and collaborating across teams to solve complex challenges. Embrace innovative experimentation and elevate scientific inquiry to dri...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$180K - $230K *

Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$83K *

Transform the candidate experience by coordinating interviews and managing communications. Collaborate with recruiters and hiring managers to streamline processes, ensuring efficiency and excellence i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Transform consumer growth by building AI-driven acquisition strategies. Lead paid and organic channels, manage a $5M+ budget, and prototype new revenue streams while developing a high-output team to d...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $215K *

Drive innovation in data engineering and AI solutions, leading the design and deployment of scalable systems. Collaborate with cross-functional teams to enhance business value through advanced technol...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Drive the success of insurance prior authorization processes by leading a team of specialists. Ensure timely approvals and minimize payment denials through effective management, communication, and pro...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$105K - $135K *

Partner with us to lead comprehensive RFP and proposal processes, crafting persuasive technical content and collaborating with cross-functional teams to enhance our credibility in the healthcare secto...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Engage with a dynamic CRO to oversee clinical monitoring and enhance site performance. Foster relationships, ensure compliance with regulations, and lead a team in delivering quality outcomes in clini...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Shape the future of clinical informatics by leading national pharmacogenomics initiatives. Collaborate across VA systems to enhance precision medicine, optimize data management, and drive impactful he...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$88K - $95K *

Drive operational excellence by leading projects across teams, enhancing efficiency, managing stakeholders, and ensuring timely delivery. Collaborate within a dynamic environment dedicated to improvin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $103K *

Empower patient care by joining a dynamic team as a FNP or PA, where you'll provide comprehensive healthcare services, collaborate with professionals, and enhance community wellness through dedicated...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$96K - $115K *

Lead the management of SaaS applications, ensuring compliance and efficiency. Collaborate across teams to maintain an accurate application catalog and streamline processes, while utilizing AI tools to...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Champion the development of clinical operations by managing a network of providers, establishing policies, and enhancing quality programs. Collaborate with leadership to ensure operational excellence...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $115K *

Innovate the recruitment landscape by sourcing top-tier executive talent, enhancing candidate experiences, and driving diversity initiatives. Collaborate with hiring managers to shape effective select...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$158K - $185K *

Unlock your potential by leading the design and delivery of a transformative Medicaid data platform. Collaborate with stakeholders and guide teams to modernize healthcare systems through innovative cl...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $100K *

Take ownership of patient care in the adult ICU, providing diagnostic, therapeutic, and preventive services under physician supervision. Collaborate with multidisciplinary teams to enhance patient out...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Unlock the potential of crypto intelligence by owning in-depth analyses of DPRK and Chinese financial threats, tracing illicit networks, and producing actionable insights for stakeholders across the g...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$93K - $120K *

Join a dynamic team as you manage clinical data throughout study lifecycles, ensuring compliance and quality. Collaborate with cross-functional teams to drive data strategy and support innovative solu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Kentucky?question toggle

    Kentucky listings may include senior and experienced roles in areas such as healthcare, manufacturing, logistics, finance, technology, sales, engineering, and operations. Available positions vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Opportunities may be found in Louisville, Lexington, Bowling Green, and communities throughout the state. Search by location to explore current openings near you.

  • Do jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with advertised salaries of $100,000 or more. Review each listing for its specific compensation details and requirements.

  • How can I find a high-paying job in Kentucky?question toggle

    Search Kentucky listings by city, role, or industry, then review the qualifications and compensation details. Tailor your resume to the position and emphasize relevant accomplishments and leadership experience.