Find high-paying career opportunities across Illinois with Ladders. Browse vetted professional jobs offering salaries of $100,000 or more, from openings in Chicago to roles in cities and communities throughout the state. Whether you’re ready to take the next step in your career or explore a new industry, discover Illinois positions that match your experience and goals.
Illinois offers a broad range of professional opportunities, with a concentration of employers and roles in the Chicago area and opportunities across the rest of the state. Explore positions in fields such as finance, technology, healthcare, manufacturing, consulting, and business leadership. Available roles and compensation vary by employer, location, and experience.
Use Ladders to explore professional openings with salaries of $100,000 or more. Review job details, compare opportunities, and focus your search on the locations, industries, and responsibilities that align with your career plans. Check listings for requirements, work arrangements, and compensation details.
Start your search for a high-paying job in Illinois by browsing current listings and applying to roles that fit your qualifications. New opportunities can become available over time, so check back regularly to find the latest vetted professional jobs on Ladders.
$110K - $130K *
Join a team that's leading Medicaid programs and initiatives, driving operational excellence and policy implementation while managing multidisciplinary teams and enhancing organizational performance a...
1 week ago
$120K - $145K *
Lead statistical strategy and analysis for oncology projects, providing expertise and collaboration across teams to facilitate regulatory submissions and improve patient outcomes in clinical trials an...
3 weeks ago
$120K - $145K *
Champion statistical leadership in clinical trials and product life-cycle management. Collaborate with multifunctional teams to develop robust methodologies and drive innovation in data analysis, ensu...
1 month ago
Business Analyst/Business Process Modeler (Remote)
$85K - $95K *
Unlock potential by leading business analysis to transform processes into actionable requirements for a major financial management system. Collaborate with stakeholders to enhance workflows and ensure...
2 weeks ago
Senior Consultant, Staff Augmentation - Decision Support
$85K - $110K *
Drive impactful client solutions by enhancing Decision Support tools and services. Collaborate with teams to optimize client experiences, mentor junior staff, and implement cost efficiency projects in...
4 days ago
$80K - $85K *
Optimize your career with a Systems Analyst role, driving technology solutions and enhancing administrative systems. Collaborate with stakeholders to achieve organizational goals while leveraging your...
3 days ago
Senior Decision Intelligence Engineer
$106K - $147K *
Champion the development of ML pipelines, ensuring scalable, reliable decision-making systems that optimize member outcomes while collaborating with cross-functional teams to enhance platform performa...
3 weeks ago
Staff Privacy Analyst - HYBRID
$105K - $230K *
Elevate your career by leading operational privacy compliance initiatives. Collaborate with cross-functional teams to enhance data privacy frameworks and manage risks while supporting regulatory chang...
2 weeks ago
Staff Privacy Analyst - HYBRID
$105K - $230K *
Advance operational privacy compliance by leading assessments, optimizing tools, and engaging stakeholders. Collaborate with teams to enhance data privacy initiatives and manage risks effectively, ens...
2 weeks ago
Staff Privacy Analyst - HYBRID
$105K - $230K *
Elevate operational privacy compliance by leading assessments, managing risks, and optimizing tools. Collaborate with stakeholders to enhance data privacy initiatives and ensure regulatory adherence w...
2 weeks ago
Vice President - Enterprise Applications
$163K - $218K *
Lead the strategy and delivery of enterprise applications, optimizing technology platforms to enhance clinical care and business operations. Collaborate with cross-functional teams to drive improvemen...
1 week ago
$80K - $95K *
Empower growth by developing strategic relationships with biotech and pharma clients. Drive market awareness and increase RFPs through collaboration with the business development team, leveraging your...
2 days ago
$120K - $160K *
Analyze complex data and drive solutions as a Business Analyst in the public sector. Leverage your expertise in pension systems to identify issues and enhance processes, ensuring effective communicati...
Reposted today
$68K - $105K *
Champion the implementation and support of Epic Beaker applications, ensuring effective system design, user experience, and problem resolution while managing projects and enhancing end-user engagement...
2 weeks ago
Executive Medical Director, Oncology Clinical Development (Solid Tumors)
$200K - $250K *
Champion the design and execution of clinical trials, leading cross-functional teams to deliver high-quality data that supports product development and regulatory compliance while ensuring adherence t...
2 weeks ago
Senior Technology Risk Analyst (IT Audit) - remote
$69K - $110K *
Join a dynamic team as you execute technology audits and risk assessments. Utilize your expertise in IT controls and compliance while collaborating with stakeholders to enhance operational effectivene...
3 weeks ago
Senior Program Finance Analyst
$82K - $172K *
Lead the charge in managing program financials, ensuring compliance and accuracy in cost, funding, and forecasting while collaborating with project managers and support teams to drive project success...
3 days ago
Enterprise Architect - Emerging Analytics
$134K - $209K *
Join a team that's redefining data architecture and analytics. Leverage your expertise to drive cloud adoption, modernize data platforms, and influence strategic initiatives that empower data-driven d...
2 weeks ago
$117K - $161K *
Elevate your career by designing and optimizing scalable data solutions. Collaborate with cross-functional teams to transform complex data into actionable insights, ensuring high standards of quality...
3 days ago
$86K - $105K *
Analyze financial data and drive forecasting processes to support business leaders. Collaborate with cross-functional teams to enhance reporting accuracy and efficiency. Deliver insights through finan...
6 days ago
U.S. Engagement Manager, Healthcare Services - 2026
$241K *
Champion client engagements and lead teams in the healthcare services sector, driving growth strategies and delivering impactful insights while managing complex projects and fostering team development...
1 week ago
$78K - $156K *
Join a team that's dedicated to enhancing business systems through design, configuration, and support. As a Senior Application Analyst, you'll lead improvements, mentor junior analysts, and ensure sea...
1 week ago
$78K - $156K *
Manage system design, enhancements, and support as a Senior Application Analyst. Collaborate with stakeholders, mentor junior team members, and improve workflows while ensuring application performance...
1 month ago
Director - Management Consulting - State & Local Government (HHS)
$179K - $298K *
Champion a dynamic team dedicated to enhancing state health and human services through strategic client engagement, quality delivery, and innovative business development while leading a diverse consul...
Reposted 4 weeks ago
$128K - $152K *
Drive advanced data analysis and regulatory reporting to enhance data quality and compliance. Collaborate with stakeholders to transform complex data into actionable insights, ensuring accuracy and op...
Reposted 1 week ago
What types of $100,000+ jobs can I find in Illinois?
Illinois listings may include professional and leadership roles in areas such as finance, technology, healthcare, manufacturing, consulting, and business operations. Job availability and qualifications vary by employer.
Are there high-paying jobs outside Chicago?
Yes. While many opportunities are based in the Chicago area, listings may also be available in other Illinois cities and communities. Search by location to explore current openings.
How can I find Illinois jobs that pay $100,000 or more?
Browse Illinois listings on Ladders and review each job’s salary information, qualifications, location, and work arrangement. Listings feature vetted professional opportunities with salaries of $100,000 or more.
Do Illinois job listings include remote or hybrid roles?
Some listings may offer remote or hybrid work, depending on the employer and position. Check each job description for the specific work arrangement.