Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
21GRAMS- Associate Medical Strategy Director
$120K - $135K *
Join a team that shapes innovative medical strategies, driving excellence in healthcare content. Collaborate with experts, cultivate client relationships, and inspire teams to elevate project outcomes...
Reposted 1 week ago
Vice President of Product Management
$235K - $265K *
Champion product innovation by leading a dynamic team to define strategy, drive decisions, and ensure successful launches that align with company growth and customer needs in the health technology sec...
2 weeks ago
$227K - $341K *
Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...
1 week ago
National Medical Director, Enterprise Partnerships, Remote
$210K - $250K *
Transform healthcare delivery by leading a team of Medical Directors and Clinical Directors, driving clinical strategy and performance excellence across portfolios while fostering relationships and in...
1 week ago
Clinical Application Specialist - DCAR
$92K - $138K *
Join a dynamic team to deliver clinical education and support for diagnostic cardiology solutions, enhancing customer experience and driving successful outcomes through expert training and collaborati...
Yesterday
Senior Analytics Solutions Engineer
$80K - $110K *
Design and develop advanced analytics solutions, transforming complex healthcare data into actionable insights using Azure Databricks and Power BI. Collaborate with cross-functional teams to enhance r...
3 days ago
Global Safety Medical Director, Rare Disease
$256K - $347K *
Lead the charge in ensuring optimal safety standards for Rare Disease products. Establish pharmacovigilance strategies, oversee safety profiles, and engage cross-functional teams to deliver critical t...
Reposted 4 weeks ago
Director, Clinical Research and Cancer Center Advisory Services
$175K - $200K *
Drive impactful change in healthcare consulting by leveraging your expertise in clinical operations and research administration. Collaborate with executive leaders to solve complex challenges and fost...
3 weeks ago
Physical Medicine and Rehabilitation Medical Director
$206K - $413K *
Join our team to lead in Physical Medicine and Rehabilitation, providing oversight, improving utilization, and guiding medical policy. Collaborate with staff and external partners to enhance healthcar...
Reposted 5 days ago
Medical Director -Pharmacy Appeals
$223K - $313K *
Shape the future of healthcare by leveraging your clinical expertise to review Medicare drug appeals, ensuring compliance and optimal value-based care through collaboration and analysis of complex cas...
6 days ago
Principal Architect, Healthcare
$165K - $243K *
Deliver innovative disaster recovery solutions for healthcare systems, ensuring compliance and resilience for clinical workloads. Collaborate with cross-functional teams to address complex challenges...
1 week ago
$150K - $175K *
Transform your career by partnering with business teams in a dynamic legal environment. Leverage your commercial instincts and regulatory expertise to make an immediate impact across two brands in a f...
2 weeks ago
Senior Denials Prevention Process Improvement Advisor
$68K - $103K *
Shape the future of revenue cycle management by driving process improvements and reducing denials. Collaborate with teams to analyze trends, implement best practices, and enhance client satisfaction t...
1 week ago
Advanced Practice Provider (NP or PA): Palliative Care
$120K - $155K *
Empower patients by delivering compassionate, patient-centered palliative care through virtual consultations. Collaborate with a dynamic team to enhance quality of life for members with complex needs...
3 weeks ago
$120K - $150K *
Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...
Reposted 1 week ago
Associate Director, Thought Leader Liaison, Oncology - Central
$157K - $256K *
Champion strategic engagements with oncology thought leaders to enhance insights and drive initiatives for our Solid Tumor portfolio, focusing on collaboration across teams and executing regional stra...
1 week ago
Vice President of Implementation
$297K - $367K *
Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...
3 weeks ago
Associate Director - Medical Science Liaison, Oncology (GI/Thoracic Focus) - Upper Midwest
$156K - $250K *
Lead the charge in scientific dialogue with key healthcare professionals, providing critical insights and support within your therapeutic area. Utilize your expertise to enhance patient outcomes and f...
Reposted 2 days ago
MGR, Contracting - Health Plan Relations (West Region)
$95K - $115K *
Drive managed care contracting activities, supporting payer negotiations and relationships. Collaborate with leadership to execute center-level priorities and enhance client satisfaction through effec...
1 week ago
$110K - $165K *
Drive impactful clinical and technical research initiatives across global teams, ensuring project success from planning to execution. Collaborate with cross-functional partners to meet quality, budget...
Yesterday
21GRAMS- VP, Medical Strategy Director
$180K - $195K *
Elevate healthcare marketing by transforming complex science into impactful strategies. Lead multidisciplinary teams to inspire creativity, drive behavior change, and build trusted client relationship...
Reposted 2 weeks ago
Managing Consultant - Clinical Documentation Integrity (CDI) - Healthcare
$120K - $165K *
Drive the successful transfer of CDI best practices by mentoring client teams, conducting record reviews, and delivering education. Collaborate with healthcare professionals to enhance documentation a...
4 weeks ago
National Account Director - Market Access & Payer Strategy
$175K - $185K *
Champion strategic payer engagement to enhance access and reimbursement across a national portfolio. Drive medical policy influence and build relationships with key stakeholders to expand coverage and...
3 weeks ago
Director, Enterprise Enablement
$150K - $180K *
Drive transformative AI initiatives across departments by leading a strategic team in designing scalable, agentic workflows that enhance decision-making and efficiency, ensuring measurable business ou...
Reposted 3 days ago
$90K - $110K *
Transform complex clinical data into compelling copy that resonates. Collaborate with cross-functional teams to create impactful healthcare campaigns, ensuring accuracy and brand voice across diverse...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.