Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Manager - Construction Relations
$80K - $95K *
Champion contractor performance by leading training and compliance efforts, enhancing safety and quality in telecommunications construction. Collaborate across teams to mitigate risks and drive improv...
3 weeks ago
$110K - $130K *
Empower your career by leading a dynamic team of Client Success Managers, driving customer satisfaction and retention while collaborating cross-functionally to maximize value from our solutions and in...
3 weeks ago
Senior Manager, Global Partner & Ecosystem Marketing
$120K - $145K *
Transform global partner marketing strategies to drive growth and engagement. Collaborate with cross-functional teams to execute integrated campaigns and optimize performance across diverse markets, e...
1 week ago
Principal AI Software Engineer
$250K - $300K *
Shape the future of AI-driven platforms by designing scalable applications and intelligent workflows. Lead initiatives that enhance operational efficiency and enable real-time insights, while mentorin...
Reposted 1 week ago
Director of Product Management
$150K - $180K *
Lead the charge in steering product management excellence, elevating team performance, and driving enterprise strategy to enhance product quality and market success through collaborative stakeholder e...
Reposted 3 weeks ago
Director of Clinical Strategy - Compliance Suite (ControlCheck & PrivacyPro)
$130K - $150K *
Shape the future of healthcare technology by leading clinical strategy initiatives to enhance drug diversion prevention and ensure patient privacy compliance. Drive impactful relationships, educate st...
Reposted 1 week ago
$137K - $231K *
Lead the charge in crafting impactful user experiences across multiple sectors. Drive design strategies, engage with customers, and collaborate closely with product and engineering teams to shape end...
Reposted 3 weeks ago
Vice President, Revenue Cycle Management
$202K - $250K *
Elevate the Personal Care department by driving strategic billing and claims initiatives, optimizing processes for accuracy and compliance, and leading a high-performing team to achieve operational ex...
Today
Product Manager, MPro - REQ # 1443
$111K - $152K *
Join a team that's redefining sales tools in HVAC. Drive strategy and execution for a next-gen sales portal, collaborating with cross-functional teams to enhance user experience and meet business goal...
2 days ago
Program Manager, Defense Manufacturing - GM Defense
$134K - $207K *
Drive cross-functional program management initiatives, ensuring successful execution from capture to delivery. Collaborate with stakeholders to align objectives, manage risks, and leverage GM's capabi...
1 week ago
$125K - $150K *
Empower your career by leading and scaling a multidisciplinary engineering team in full-stack and data engineering. Drive impact through collaboration and technical excellence, ensuring quality and in...
Reposted 3 weeks ago
Manager, Software Engineering - Engineering Tools
$120K - $148K *
Join a team that's shaping the future of AEC software by leading engineering talent and enhancing workflows. Drive innovation in Autodesk Revit add-ins and tools while fostering a collaborative enviro...
1 week ago
Senior Manager, Lien Negotiation
$110K - $130K *
Lead the charge in building and managing a lien negotiation function, overseeing complex medical lien resolutions while driving team performance and compliance to maximize client recoveries and stream...
2 weeks ago
Clinical Trial Manager II, Dermatology & Rheumatology CRO, USA
$100K - $120K *
Engage with a dynamic CRO to oversee clinical monitoring and enhance site performance. Foster relationships, ensure compliance with regulations, and lead a team in delivering quality outcomes in clini...
Reposted 3 weeks ago
Senior Customer Success Operations Manager
$104K - $176K *
Lead operational excellence within the Customer Success teams, driving impactful programs that enhance performance and efficiency while fostering collaboration across cross-functional teams in a dynam...
Reposted 3 weeks ago
Senior Manager, Relationship Management
$125K - $145K *
Drive client success and retention by leading a team of managers to ensure exceptional service and satisfaction while leveraging data-driven insights and proactive strategies for account management im...
3 weeks ago
Senior Product Manager, Consumer (B2C)
$120K - $145K *
Inspire innovation and drive growth as you lead the consumer product line across web, mobile, and desktop platforms, crafting a unified user experience and championing customer-centric strategies for...
Reposted 3 weeks ago
Senior Director, Regulatory CMC
$220K - $275K *
Elevate your career by leading global CMC regulatory strategies for biologics. Collaborate with cross-functional teams, ensure compliance, and drive successful product development while mentoring a hi...
Reposted 2 weeks ago
$105K - $163K *
Transform database environments by leading architecture and administration efforts across multiple platforms, ensuring compliance and performance for mission-critical applications in a dynamic, remote...
1 week ago
Manager, Simulation Operations
$182K - $263K *
Drive simulation operations by leading a hybrid team to execute high-quality tests, establish evaluation metrics, and enhance processes using AI for improved operational performance across virtual tes...
Reposted 3 weeks ago
Director, Executive Compensation
$156K - $227K *
Champion executive compensation strategies that align with business objectives. Lead the design and execution of Total Rewards programs, provide expert consultations, and drive cross-functional collab...
1 month ago
$150K - $200K *
Accelerate progress at the forefront of product innovation, leading a team to drive strategy and customer experience for a key transaction management platform while embedding AI to enhance efficiency...
4 days ago
Award Transition Project Manager
$100K - $120K *
Champion seamless transitions by managing federal project awards from contract to construction. Collaborate with teams to ensure timely execution of all requirements, driving efficiency and clarity th...
1 week ago
$175K - $210K *
Join a team that's transforming financial oversight globally, ensuring compliance and efficiency. Lead accounting processes, enhance internal controls, and drive automation while mentoring a high-perf...
5 days ago
Director, Performance and Growth Marketing
$125K - $150K *
Lead the charge in demand generation and performance marketing, optimizing campaigns and funnel reporting. Collaborate with Sales and Revenue Operations to enhance data infrastructure and drive measur...
Today
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.