Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Director, Project Management Jobs in South Dakota

Sort By: Relevance

$80K - $95K *

Champion contractor performance by leading training and compliance efforts, enhancing safety and quality in telecommunications construction. Collaborate across teams to mitigate risks and drive improv...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$110K - $130K *

Empower your career by leading a dynamic team of Client Success Managers, driving customer satisfaction and retention while collaborating cross-functionally to maximize value from our solutions and in...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Transform global partner marketing strategies to drive growth and engagement. Collaborate with cross-functional teams to execute integrated campaigns and optimize performance across diverse markets, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$250K - $300K *

Shape the future of AI-driven platforms by designing scalable applications and intelligent workflows. Lead initiatives that enhance operational efficiency and enable real-time insights, while mentorin...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$150K - $180K *

Lead the charge in steering product management excellence, elevating team performance, and driving enterprise strategy to enhance product quality and market success through collaborative stakeholder e...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$130K - $150K *

Shape the future of healthcare technology by leading clinical strategy initiatives to enhance drug diversion prevention and ensure patient privacy compliance. Drive impactful relationships, educate st...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$137K - $231K *

Lead the charge in crafting impactful user experiences across multiple sectors. Drive design strategies, engage with customers, and collaborate closely with product and engineering teams to shape end...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$202K - $250K *

Elevate the Personal Care department by driving strategic billing and claims initiatives, optimizing processes for accuracy and compliance, and leading a high-performing team to achieve operational ex...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Healthcare

$111K - $152K *

Join a team that's redefining sales tools in HVAC. Drive strategy and execution for a next-gen sales portal, collaborating with cross-functional teams to enhance user experience and meet business goal...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$134K - $207K *

Drive cross-functional program management initiatives, ensuring successful execution from capture to delivery. Collaborate with stakeholders to align objectives, manage risks, and leverage GM's capabi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Empower your career by leading and scaling a multidisciplinary engineering team in full-stack and data engineering. Drive impact through collaboration and technical excellence, ensuring quality and in...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $148K *

Join a team that's shaping the future of AEC software by leading engineering talent and enhancing workflows. Drive innovation in Autodesk Revit add-ins and tools while fostering a collaborative enviro...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the charge in building and managing a lien negotiation function, overseeing complex medical lien resolutions while driving team performance and compliance to maximize client recoveries and stream...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Engage with a dynamic CRO to oversee clinical monitoring and enhance site performance. Foster relationships, ensure compliance with regulations, and lead a team in delivering quality outcomes in clini...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$104K - $176K *

Lead operational excellence within the Customer Success teams, driving impactful programs that enhance performance and efficiency while fostering collaboration across cross-functional teams in a dynam...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $145K *

Drive client success and retention by leading a team of managers to ensure exceptional service and satisfaction while leveraging data-driven insights and proactive strategies for account management im...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Inspire innovation and drive growth as you lead the consumer product line across web, mobile, and desktop platforms, crafting a unified user experience and championing customer-centric strategies for...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$220K - $275K *

Elevate your career by leading global CMC regulatory strategies for biologics. Collaborate with cross-functional teams, ensure compliance, and drive successful product development while mentoring a hi...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$105K - $163K *

Transform database environments by leading architecture and administration efforts across multiple platforms, ensuring compliance and performance for mission-critical applications in a dynamic, remote...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$182K - $263K *

Drive simulation operations by leading a hybrid team to execute high-quality tests, establish evaluation metrics, and enhance processes using AI for improved operational performance across virtual tes...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Transportation

$156K - $227K *

Champion executive compensation strategies that align with business objectives. Lead the design and execution of Total Rewards programs, provide expert consultations, and drive cross-functional collab...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $200K *

Accelerate progress at the forefront of product innovation, leading a team to drive strategy and customer experience for a key transaction management platform while embedding AI to enhance efficiency...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $120K *

Champion seamless transitions by managing federal project awards from contract to construction. Collaborate with teams to ensure timely execution of all requirements, driving efficiency and clarity th...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$175K - $210K *

Join a team that's transforming financial oversight globally, ensuring compliance and efficiency. Lead accounting processes, enhance internal controls, and drive automation while mentoring a high-perf...

United StatesRemote

5 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in demand generation and performance marketing, optimizing campaigns and funnel reporting. Collaborate with Sales and Revenue Operations to enhance data infrastructure and drive measur...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.