Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$149K - $205K *

Elevate innovation at the forefront of foodtech, agritech, and infrastructure. Lead strategic initiatives, build ecosystems, and drive new ventures to shape the future landscape of Mitsubishi Electric...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$179K - $298K *

Champion financial management excellence by leading teams to enhance processes, conduct risk assessments, and integrate data capabilities, ensuring continuous audit readiness and fraud prevention for...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Business Services

$140K - $170K *

Advance project execution by managing vendor relationships and internal teams to deliver a new web-based application. Oversee timelines, risks, and stakeholder alignment to ensure successful project o...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Staffing

$154K - $260K *

Join an innovative team to lead and evolve critical Core Infrastructure. Oversee infrastructure strategy, improve operational health, and drive automation to boost performance across a globally distri...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$135K - $150K *

Join a team that's shaping the future of healthcare by leading M&A integration efforts. Drive strategic initiatives, manage high-stakes projects, and collaborate with senior leadership to enhance grow...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$207K - $311K *

Shape the future of our global GTM strategy by leading capacity planning, territory design, and incentive structures, driving growth and operational excellence across Sales and Customer Success framew...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$100K - $120K *

Advance global clinical trials by leading cross-functional teams, ensuring compliance and operational excellence while managing timelines and budgets to deliver impactful results in Oncology research...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$225K - $265K *

Partner with us to lead a high-performing engineering team, driving innovation and efficiency in our travel marketplace. You'll manage project lifecycles, enhance collaboration, and champion a custome...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$114K - $187K *

Champion clinical laboratory operations by managing complex projects, ensuring timely study starts, and collaborating with cross-functional teams to deliver impactful results in precision medicine...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$157K - $283K *

Lead the charge in driving business growth by developing strategic partnerships and innovative solutions for federal clients, while collaborating with cross-functional teams to deliver exceptional res...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $180K *

Drive the planning and execution of complex therapeutic programs from discovery to clinic. Serve as a senior program management partner, ensuring successful execution and alignment across cross-functi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Lead global field operations, driving strategy and execution across sales, technical services, and partner functions. Collaborate with senior leadership to optimize pipeline management, forecasting, a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead the optimization of cross-pillar workflows, ensuring technical soundness and operational effectiveness. Collaborate with engineering and product teams to enhance product adoption and drive measur...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $125K *

Advance your career by coordinating healthcare technology integration across multiple VA sites. Leverage your project management skills to support the Federal Electronic Health Record Modernization pr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$128K - $178K *

Lead the charge in shaping the future of destination marketing through data-driven insights and innovative product strategies. Collaborate with cross-functional teams to enhance customer experiences a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$216K - $236K *

Join a team that's redefining AI product management by driving ROI through innovative solutions. Lead the development of AI capabilities that enhance Alteryx workflows, ensuring faster, better, and ch...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$160K - $195K *

Drive operational excellence and lead a high-performing team to deliver complex digital products. Collaborate with cross-functional teams to define strategies, manage resources, and ensure profitable...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$102K - $154K *

Lead the charge in managing complex customer escalations, driving rapid resolutions and systemic improvements. Collaborate cross-functionally to enhance workflows and customer experiences while ensuri...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$122K - $184K *

Lead the implementation of Workday solutions in Higher Education, managing project lifecycles, fostering client relationships, and delivering results while ensuring adherence to budget and timelines...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$160K - $200K *

Empower your career with a senior finance leadership role, driving strategic financial planning and operational excellence as our organization scales its impact globally, fostering a culture of analyt...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$160K - $200K *

Join a team that's redefining forensics and collections globally. Lead a skilled team, enhance operational efficiency, and drive client engagement while ensuring compliance and defensibility across re...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Legal & Accounting

$90K - $100K *

Manage multiple digital programs, ensuring exceptional delivery and operational efficiency. Collaborate with client services and channel teams to achieve goals while thriving in a fast-paced environme...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$134K - $241K *

Join a team that's dedicated to executing complex utility projects, overseeing planning, quality assurance, and timely delivery. Your leadership will drive project success and ensure adherence to clie...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$140K - $170K *

Lead the charge in shaping portfolio-level product strategy for P&C insurance technology. Collaborate across multiple product lines to drive data-driven investment decisions and enhance overall portfo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Unlock your potential to lead programmatic strategies, shape best practices, and empower teams to excel in the DSP landscape. Collaborate with stakeholders and transform our approach to digital advert...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.