Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$125K - $150K *

Drive enterprise growth by engaging top health system executives, transforming clinical outcomes through innovative solutions, and building strategic partnerships to expand market presence and adoptio...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$119K - $190K *

Shape the future of our Corporate Functions by partnering with senior leaders to drive talent strategy, organizational effectiveness, and leadership development. Leverage data and insights to influenc...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate business performance by leading financial planning and analysis efforts. Collaborate with cross-functional teams to transform data into actionable insights, driving strategic decision-making a...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Transform financial data into strategic insights as you lead a global team in financial planning, forecasting, and performance reporting, driving operational excellence and sustainable growth across t...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Transform financial data into strategic insights, leading a global team in budgeting, forecasting, and performance analysis to drive operational excellence and sustainable growth across the business u...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Champion organizational change and communications, driving adoption and readiness across teams. Lead strategy, establish governance, and enhance capabilities for effective transformation initiatives w...

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$137K - $235K *

Lead the charge in shaping customer master data strategy, connecting cross-functional teams to ensure trusted information drives commercial success and operational excellence in the pharmaceutical ind...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $130K *

Transform supply chain operations by leading strategic planning, optimizing resources, and enhancing service delivery. Collaborate with teams to drive cost efficiencies and ensure compliance while fos...

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$108K - $130K *

Join a dynamic team to lead strategic and operational planning for Supply Chain functions, ensuring efficient service delivery and cost management across various departments while fostering strong int...

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Unlock potential by overseeing financial operations and analytics for multiple departments, ensuring compliance and budget adherence while collaborating with leadership to enhance revenue cycle perfor...

6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead the charge in clinical study start-up operations, driving team development and ensuring timely site activation. Collaborate cross-functionally to enhance processes, meet regulatory standards, and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive HR strategy and compliance across multiple sites, leading teams to enhance operational performance and business continuity. Collaborate with leaders to implement HR initiatives that foster inclu...

3 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$182K - $240K *

Pioneer a high-impact Corporate Systems strategy, leading a dedicated Product Management team to transform internal platforms. Drive cross-functional initiatives in Finance, People, and Sales to deliv...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$162K - $185K *

Drive strategic product development to meet growth goals, prioritizing user impact and results while collaborating with cross-functional teams to deliver innovative solutions that resonate with both B...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Empower strategic financial decisions by analyzing investments, market opportunities, and capital allocation. Collaborate with C-suite executives to drive growth and optimize resource allocation while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$129K - $240K *

Lead the charge in redefining global planning processes for the Diagnostics Division. Drive innovation, align strategies with long-term goals, and inspire a high-performing international team to achie...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$173K - $272K *

Join us to lead a talented team of scientists in advancing large molecule programs, driving operational excellence, and fostering strategic partnerships to enhance clinical supply and commercializatio...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $138K *

Transform project execution by managing operations, schedules, and budgets for solar PV projects. Leverage your expertise in construction and leadership to ensure quality and efficiency across multipl...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$122K - $204K *

Shape the future of operations by providing strategic leadership, driving measurable improvements, and fostering cross-functional collaboration to enhance performance, service quality, and customer ou...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$123K - $196K *

Accelerate progress at our firm by leading the implementation and onboarding of Wealth Advisory clients. Manage a dedicated team, ensuring exceptional service and operational excellence while collabor...

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$153K - $213K *

Drive efficiency by automating internal processes, enhancing productivity across teams. Collaborate with stakeholders to identify bottlenecks, implement AI solutions, and ensure measurable impact on w...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$165K - $185K *

Join a team that's shaping strategic direction and driving growth across multi-account projects in medical affairs. In this senior leadership role, you'll enhance client relationships, develop teams...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$70K - $95K *

Join a team that's driving energy efficiency initiatives by engaging contractors and customers, promoting financing options, and ensuring seamless integration into project development for sustainable...

Reposted 1 month ago

  •   Less than 5 years exp.  •   Energy & Utilities

$175K - $210K *

Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Unlock growth by leading sales initiatives and driving new opportunities in Salesforce services. Collaborate with teams to develop strategic solutions, manage client relationships, and exceed revenue...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.