Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$124K - $155K *

Drive strategic U.S. revenue growth initiatives by leveraging pricing, trade optimization, and analytics. Collaborate across teams to enhance forecasting accuracy and data integrity, influencing high...

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$95K - $115K *

Manage daily operations of supply chain projects, coordinating product selection, deliveries, and installations. Collaborate with internal teams to ensure compliance and optimize project outcomes whil...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$115K - $140K *

Join a team that's dedicated to transforming patient engagement through innovative marketing strategies. You'll develop and execute multichannel campaigns, crafting compelling content that drives enro...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a dynamic team as you lead commissioning projects, ensuring compliance with ASHRAE, CSA, and LEED standards. Collaborate with diverse stakeholders while executing technical activities across all...

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$214K - $358K *

Champion clinical excellence by leading a high-performing team in innovative clinical development. Drive strategic initiatives, optimize resources, and integrate advanced analytics to enhance patient...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in driving integrated execution of Medical Affairs priorities, ensuring alignment across global and regional teams. Oversee program management, budget coordination, and strategic plann...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Innovate product management by leading the evolution of legacy and cloud solutions. Drive customer adoption, improve outcomes, and enhance user experience while collaborating with cross-functional tea...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead the proposal development process for high-value bids, collaborating across departments to create compelling responses. Drive strategy, ensure compliance, and mentor team members while enhancing p...

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Drive your career forward by leading the enterprise testing strategy, enhancing quality engineering practices, and fostering collaboration across teams to ensure reliability and consistency in complex...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Lead the future of healthcare business operations by driving growth, optimizing performance, and ensuring customer satisfaction. Collaborate with cross-functional teams to achieve strategic goals and...

Exton, PARemote

3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $170K *

Pioneer innovative solutions in P&C insurance by owning the product roadmap for policy administration and commercial underwriting, integrating AI capabilities to enhance decision-making and streamline...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Accelerate progress at managing Joint Pole Committee services, leading personnel, ensuring quality and productivity, and coordinating customer deliverables while supporting program execution and issue...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$100K - $120K *

Accelerate sales growth by managing hardware and service functions across a designated territory. Drive project management and customer relationships to meet revenue and profitability goals while ensu...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Join a team that's redefining the buyer experience in B2B software. As a Principal Product Manager, you'll lead strategy, drive product delivery, and enhance buyer trust across multiple platforms, ens...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$114K - $187K *

Empower clinical studies by leading data management efforts, ensuring compliance and quality throughout the trial lifecycle. Collaborate with teams to optimize processes and enhance data integrity, me...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$209K - $349K *

Lead the engineering strategy and modernization efforts for a major technology platform, ensuring seamless integration and client transitions while driving organizational alignment and operational exc...

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$170K - $180K *

Drive enterprise leadership in commercial planning and sales execution, translating business priorities into coordinated actions for profitable growth. Collaborate across functions to enhance sales st...

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $150K *

Lead the charge in building long-term customer relationships while optimizing operations. As a Business Manager, you'll drive strategic growth, manage key accounts, and collaborate across teams to enh...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$160K - $185K *

Lead client engagements in Real-World Data solutions, ensuring operational excellence and strong outcomes. Collaborate cross-functionally to translate client objectives into actionable plans, driving...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$206K - $343K *

Lead the charge in transforming healthcare operations by delivering innovative performance solutions. Drive profitable growth through strategic program management and client engagement, ensuring measu...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$108K - $180K *

Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in delivering complex industrial projects, ensuring alignment with budget, schedule, and quality standards while fostering strong client relationships and mentoring project teams throu...

Reposted yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Unlock potential by leading a dynamic supply chain team to optimize operations, drive strategic initiatives, and enhance supplier performance, ensuring alignment with business objectives and fostering...

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$200K *

Drive technical excellence by translating creative visions into actionable plans. Oversee pre-production, CAD drafting, and on-site execution, ensuring projects are delivered safely, on time, and with...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$90K - $125K *

Lead the development and submission of federal proposals, managing teams and resources to deliver compliant, compelling responses. Collaborate with cross-functional teams to ensure alignment with cust...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.