Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$140K - $180K *

Innovate with us as you lead technical delivery for enterprise data integration and migration projects, focusing on Higher Education and Salesforce ecosystems. Drive solution architecture, manage team...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate client partnerships by managing a diverse portfolio in healthcare. Lead strategic growth initiatives, foster relationships with C-suite leaders, and mentor teams to deliver impactful solutions...

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$114K - $187K *

Optimize clinical data management processes by leading teams and ensuring compliance with standards. Collaborate with stakeholders to enhance data quality and streamline operations across multiple com...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Accelerate progress at R&D by leading resource and schedule management, ensuring alignment with strategic goals, and driving continuous improvement through data-driven insights and stakeholder collabo...

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$122K - $212K *

Empower the modernization of Clinical Risk Management through strategic digital leadership, aligning investments with quality and compliance priorities while driving process optimization and data acce...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$122K - $212K *

Shape the future of clinical risk management by leading digital transformation initiatives, defining strategic priorities, and ensuring alignment across cross-functional teams to enhance quality and c...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$122K - $212K *

Shape the future of clinical risk management by leading digital transformation initiatives. Drive strategy, governance, and cross-functional collaboration to enhance data accessibility and quality, en...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$122K - $212K *

Shape the future of clinical risk management by leading digital transformation initiatives, defining strategic priorities, and ensuring alignment across cross-functional teams to enhance data quality...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$122K - $212K *

Shape the future of clinical risk management by leading digital transformation initiatives. Drive strategy, governance, and cross-functional collaboration to enhance data quality and accessibility whi...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$255K - $310K *

Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$130K - $165K *

Join a talented team as you tackle critical finance initiatives, support M&A integration, and implement transformative processes. Contribute to high-impact projects while advancing your career in a dy...

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$105K - $150K *

Transform healthcare insights by leading client engagements with real-world data. Drive business development and project delivery while building long-term client relationships in a dynamic, hybrid wor...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$115K - $171K *

Champion strategic growth by leading analyses that drive international expansion and acquisitions. Collaborate with senior leaders to shape decisions and deploy AI agents for enhanced efficiency in a...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Shape the future of revenue operations by transforming data into actionable insights. Collaborate with cross-functional teams to enhance performance metrics, streamline reporting, and drive strategic...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead the charge in managing complex transportation projects, delivering innovative solutions through expert guidance and team collaboration. Drive operational excellence while fostering client relatio...

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$80K - $95K *

Champion cross-functional projects to enhance operational efficiency and achieve organizational goals. Lead initiatives from planning to completion, ensuring timely delivery within scope and budget wh...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$75K - $90K *

Transform your career with impactful auditing and training roles in risk adjustment. Collaborate with management to enhance coding compliance, drive performance improvement, and foster a culture of ex...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Transform patient safety operations by leading a dedicated team, ensuring compliance, and enhancing pharmacovigilance processes. Collaborate cross-functionally to deliver high-quality safety services...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive healthcare construction projects to align with strategic goals, ensuring efficient operations and exceptional patient care. Manage multiple projects, coordinate resources, and engage stakeholder...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Drive engineering excellence by leading high-performing teams in real-time video and media processing. Collaborate across functions to translate business goals into scalable software solutions while e...

2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$150K - $180K *

Partner with us to enhance financial performance through cost controlling, SAP CO leadership, and data integrity. Drive strategic insights and process improvements while collaborating across functions...

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $108K *

Champion high-impact strategic initiatives, collaborating with executives to drive alignment and measurable results across the organization while navigating complexity and change...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Technical Services

$229K - $267K *

Optimize consumer acquisition strategies to drive growth and innovation across multiple channels. Lead a high-performing team, manage budgets, and define future goals while ensuring effective executio...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$169K - $255K *

Shape the future of personalized consumer products by driving strategic partnerships and revenue growth. Lead business development efforts, cultivate relationships, and expand market reach to position...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$169K - $255K *

Join a team that's driving growth through strategic partnerships in personalized consumer products. Lead initiatives to expand market reach and revenue streams while collaborating across functions to...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.