Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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1,000+

Director, Project Management Jobs in Pennsylvania

Sort By: Relevance

$150K - $180K *

Drive the planning and execution of complex therapeutic programs from discovery to clinic. Serve as a senior program management partner, ensuring successful execution and alignment across cross-functi...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Take ownership of client project implementations, managing all lifecycle phases from kickoff to launch. Collaborate with teams to ensure timely delivery, monitor project scope and financials, and proa...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Lead global field operations, driving strategy and execution across sales, technical services, and partner functions. Collaborate with senior leadership to optimize pipeline management, forecasting, a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Lead complex automation projects from design to implementation, ensuring successful delivery of AGV systems. Collaborate with cross-functional teams to enhance safety, productivity, and operational ef...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$185K - $344K *

Join a dynamic team driving strategic planning and performance management across analytics capabilities. Lead portfolio governance and execution initiatives to align resources and priorities, ensuring...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$124K - $280K *

Champion innovative AI-driven product development in the pharmaceutical sector. Lead a diverse team, driving an AI-first mindset while ensuring quality and performance across complex data and analytic...

Today

  •   5 - 7 years exp.  •   Legal & Accounting

$95K - $115K *

Champion innovative design solutions by leading a creative team, developing scalable systems, and collaborating across multiple projects to deliver compelling visual concepts that elevate brand identi...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the optimization of cross-pillar workflows, ensuring technical soundness and operational effectiveness. Collaborate with engineering and product teams to enhance product adoption and drive measur...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $125K *

Advance your career by coordinating healthcare technology integration across multiple VA sites. Leverage your project management skills to support the Federal Electronic Health Record Modernization pr...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$128K - $178K *

Lead the charge in shaping the future of destination marketing through data-driven insights and innovative product strategies. Collaborate with cross-functional teams to enhance customer experiences a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$123K - $218K *

Champion user-centered information experiences by leading a distributed team to create impactful technical documentation and content strategies that enhance customer and developer engagement across mu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate your career by managing complex e-discovery projects, mentoring teams, and collaborating with legal professionals to ensure successful outcomes. Drive project execution while fostering strong...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $95K *

Lead dynamic onsite projects, collaborating with teams to ensure success through effective management of structural steel erection and installation, while maintaining strong client relationships and o...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Unlock potential by driving product strategy for AI platforms, owning the VisionAI roadmap while collaborating across teams to meet market needs and enhance customer adoption in a fast-paced, evolving...

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$216K - $236K *

Join a team that's redefining AI product management by driving ROI through innovative solutions. Lead the development of AI capabilities that enhance Alteryx workflows, ensuring faster, better, and ch...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$220K - $240K *

Innovate customer-centric digital strategies, leading engineering teams to enhance e-commerce platforms and mobile applications, driving measurable growth in traffic, conversion, and satisfaction thro...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Staffing

$160K - $195K *

Drive operational excellence and lead a high-performing team to deliver complex digital products. Collaborate with cross-functional teams to define strategies, manage resources, and ensure profitable...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$95K - $115K *

Transform global healthcare by managing strategic client projects, ensuring seamless execution from start to finish. Collaborate with teams to enhance processes and deliver optimal solutions, making a...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$102K - $154K *

Lead the charge in managing complex customer escalations, driving rapid resolutions and systemic improvements. Collaborate cross-functionally to enhance workflows and customer experiences while ensuri...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the charge in enhancing quality management systems, ensuring compliance and customer satisfaction while driving the Zero Defects program across divisions. Collaborate with leadership to foster a...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Advance your career by managing diverse construction projects, ensuring alignment with organizational goals through effective operations and project management, key metrics utilization, and stakeholde...

4 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$200K - $220K *

Lead product management for an innovative infrastructure automation platform, driving strategy and vision while managing a team of senior product managers. Collaborate cross-functionally to enhance cu...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$122K - $184K *

Lead the implementation of Workday solutions in Higher Education, managing project lifecycles, fostering client relationships, and delivering results while ensuring adherence to budget and timelines...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$100K - $130K *

Partner with us to enhance project financial performance and operational excellence. Leverage your expertise in project controls and financial analysis to drive insights, improve practices, and suppor...

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$160K - $200K *

Join a team that's redefining forensics and collections globally. Lead a skilled team, enhance operational efficiency, and drive client engagement while ensuring compliance and defensibility across re...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.