Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Materials Senior Project Manager
$100K - $120K *
Manage complex engineering projects from inception to completion, ensuring safety, budget adherence, and timely delivery. Collaborate with clients and stakeholders to navigate challenges and drive pro...
Yesterday
Senior Clinical Project Manager
$120K - $145K *
Join a team that's advancing oncology solutions by managing global clinical trials. Lead project execution from protocol development to study closeout, ensuring quality and compliance while fostering...
4 weeks ago
Project Manager, Financial Benefits
$98K - $122K *
Empower progress at the intersection of project management and benefits innovation. Lead initiatives for 401(k) MEP and Benefits Billing, collaborating with diverse stakeholders to enhance operational...
1 week ago
$135K - $160K *
Drive clinical data management excellence by leading strategies, ensuring data integrity, and collaborating across functions to support successful clinical trials and regulatory submissions in a dynam...
1 week ago
Project Manager - Commissioning
$120K - $170K *
Optimize project success by leading comprehensive commissioning efforts across critical facilities, managing all phases from planning to turnover, ensuring compliance, quality, and client satisfaction...
Reposted 1 week ago
Sr Project Manager (Civil Construction)
$100K - $120K *
Transform project delivery by leading diverse teams, managing budgets, and ensuring quality across multiple civil infrastructure projects while fostering strong relationships with stakeholders and dri...
3 weeks ago
$100K - $125K *
Champion the development of healthcare marketing tools by guiding cross-functional teams through the product lifecycle, driving innovative features and optimizing user experiences to enhance HCP engag...
Reposted 3 weeks ago
Director, Workforce Management
$161K - $210K *
Elevate workforce management by leading recruitment, onboarding, and performance strategies. Drive clinician readiness and productivity while ensuring quality care through data-driven decision-making...
Reposted 4 days ago
$150K - $160K *
Create impactful data solutions by leading a cross-functional team in managing high-priority IT projects for federal clients. Drive collaboration and ensure project success through effective communica...
Reposted 1 week ago
Project Manager - Construction
$95K - $115K *
Lead and manage complex construction projects, ensuring safety, quality, and client satisfaction while coordinating with diverse teams and stakeholders to deliver on time and within budget...
Reposted 2 weeks ago
Project Manager - Construction
$95K - $115K *
Lead the charge in executing complex construction projects, ensuring safety, quality, and client satisfaction. Collaborate with diverse teams to drive project success from planning to closeout while m...
Reposted 2 weeks ago
Director, Global People Services
$135K - $160K *
Shape the future of global employee services by leading a scalable organization that enhances support, streamlines processes, and leverages AI for seamless service delivery across diverse regions and...
Yesterday
Senior Director Access Experience Team
$191K - $280K *
The Senior Director of the Access Experience Team will lead strategic initiatives for clients in the pharmaceutical and life sciences sectors, focusing on payer marketing and access strategies. This r...
Reposted 1 week ago
Program Manager, Product Data Operations, Family of Apps
$120K - $145K *
Lead the charge in managing cross-functional programs that enhance AI data quality and evaluation. Collaborate with diverse teams to translate product needs into actionable plans, ensuring efficient d...
2 weeks ago
Senior Manager, Project Controls, Project & Development Services
$148K - $175K *
Elevate your career by providing strategic oversight of project controls, balancing technical leadership with client advisory support. Mentor teams and influence delivery models while contributing to...
3 weeks ago
Project Manager - Relocation/Construction
$80K - $95K *
Lead and manage client relocations, ensuring seamless transitions through effective planning, coordination, and communication with stakeholders while maintaining budget and schedule integrity...
2 days ago
Project Manager - Construction
$80K - $95K *
Elevate your career by managing diverse capital improvement projects, serving as a trusted advisor throughout the project lifecycle, and ensuring exceptional client service while meeting scope, budget...
Reposted 5 days ago
$92K - $134K *
Join us to lead the charge in managing a $32M facility upgrade project, ensuring effective collaboration with teams and stakeholders while maintaining safety and quality standards throughout the const...
2 weeks ago
Director, Business Applications
$120K - $145K *
Transform the future of business applications by leading strategy, delivery, and operations. Collaborate with multidisciplinary teams to enhance core processes and drive value through effective system...
3 weeks ago
Senior Manager - Project Program Management
$75K - $165K *
Advance enterprise-wide operational leadership for HEDIS, CAHPS, and provider surveys. Lead survey planning, execution, and compliance while managing vendor performance and budget activities to enhanc...
Yesterday
$95K - $150K *
Lead the successful delivery of complex automation projects, ensuring alignment with specifications and timelines. Collaborate with cross-functional teams to manage risks and maintain quality standard...
1 week ago
Senior Project Manager, Events
$115K - $150K *
Advance project efficiency by managing multiple high-scale events seamlessly. Oversee logistics, stakeholder coordination, and maintain clarity within a fast-paced environment while ensuring that ever...
Reposted yesterday
Senior Project Manager, Traffic Engineer
$135K - $185K *
Join our team to lead complex traffic engineering projects, managing a distributed group while delivering innovative transportation solutions. Leverage your expertise in traffic operations and project...
1 week ago
Senior Project Manager, Traffic Engineer
$135K - $185K *
Champion innovative traffic engineering solutions by leading complex projects, managing a distributed team, and collaborating across disciplines to enhance transportation systems for state and local a...
1 week ago
Senior Program Manager/Engineering Manager
$125K - $225K *
Lead the charge in multidisciplinary engineering and design management for a large-scale industrial infrastructure project, ensuring compliance with technical standards and client expectations through...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.