Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$100K - $120K *

Manage complex engineering projects from inception to completion, ensuring safety, budget adherence, and timely delivery. Collaborate with clients and stakeholders to navigate challenges and drive pro...

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$120K - $145K *

Join a team that's advancing oncology solutions by managing global clinical trials. Lead project execution from protocol development to study closeout, ensuring quality and compliance while fostering...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$98K - $122K *

Empower progress at the intersection of project management and benefits innovation. Lead initiatives for 401(k) MEP and Benefits Billing, collaborating with diverse stakeholders to enhance operational...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$135K - $160K *

Drive clinical data management excellence by leading strategies, ensuring data integrity, and collaborating across functions to support successful clinical trials and regulatory submissions in a dynam...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $170K *

Optimize project success by leading comprehensive commissioning efforts across critical facilities, managing all phases from planning to turnover, ensuring compliance, quality, and client satisfaction...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $120K *

Transform project delivery by leading diverse teams, managing budgets, and ensuring quality across multiple civil infrastructure projects while fostering strong relationships with stakeholders and dri...

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $125K *

Champion the development of healthcare marketing tools by guiding cross-functional teams through the product lifecycle, driving innovative features and optimizing user experiences to enhance HCP engag...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$161K - $210K *

Elevate workforce management by leading recruitment, onboarding, and performance strategies. Drive clinician readiness and productivity while ensuring quality care through data-driven decision-making...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $160K *

Create impactful data solutions by leading a cross-functional team in managing high-priority IT projects for federal clients. Drive collaboration and ensure project success through effective communica...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Lead and manage complex construction projects, ensuring safety, quality, and client satisfaction while coordinating with diverse teams and stakeholders to deliver on time and within budget...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Lead the charge in executing complex construction projects, ensuring safety, quality, and client satisfaction. Collaborate with diverse teams to drive project success from planning to closeout while m...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$135K - $160K *

Shape the future of global employee services by leading a scalable organization that enhances support, streamlines processes, and leverages AI for seamless service delivery across diverse regions and...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$191K - $280K *

The Senior Director of the Access Experience Team will lead strategic initiatives for clients in the pharmaceutical and life sciences sectors, focusing on payer marketing and access strategies. This r...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Lead the charge in managing cross-functional programs that enhance AI data quality and evaluation. Collaborate with diverse teams to translate product needs into actionable plans, ensuring efficient d...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$148K - $175K *

Elevate your career by providing strategic oversight of project controls, balancing technical leadership with client advisory support. Mentor teams and influence delivery models while contributing to...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$80K - $95K *

Lead and manage client relocations, ensuring seamless transitions through effective planning, coordination, and communication with stakeholders while maintaining budget and schedule integrity...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$80K - $95K *

Elevate your career by managing diverse capital improvement projects, serving as a trusted advisor throughout the project lifecycle, and ensuring exceptional client service while meeting scope, budget...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$92K - $134K *

Join us to lead the charge in managing a $32M facility upgrade project, ensuring effective collaboration with teams and stakeholders while maintaining safety and quality standards throughout the const...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $145K *

Transform the future of business applications by leading strategy, delivery, and operations. Collaborate with multidisciplinary teams to enhance core processes and drive value through effective system...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$75K - $165K *

Advance enterprise-wide operational leadership for HEDIS, CAHPS, and provider surveys. Lead survey planning, execution, and compliance while managing vendor performance and budget activities to enhanc...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $150K *

Lead the successful delivery of complex automation projects, ensuring alignment with specifications and timelines. Collaborate with cross-functional teams to manage risks and maintain quality standard...

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $150K *

Advance project efficiency by managing multiple high-scale events seamlessly. Oversee logistics, stakeholder coordination, and maintain clarity within a fast-paced environment while ensuring that ever...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $185K *

Join our team to lead complex traffic engineering projects, managing a distributed group while delivering innovative transportation solutions. Leverage your expertise in traffic operations and project...

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$135K - $185K *

Champion innovative traffic engineering solutions by leading complex projects, managing a distributed team, and collaborating across disciplines to enhance transportation systems for state and local a...

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$125K - $225K *

Lead the charge in multidisciplinary engineering and design management for a large-scale industrial infrastructure project, ensuring compliance with technical standards and client expectations through...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.