Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Advance the administration of Defined Benefit and Retiree Medical plans, ensuring accurate valuations, benefit calculations, and compliance with regulations. Collaborate on special projects while leve...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$104K - $140K *

Transform financial systems by leading a high-performing team to enhance Workday Financials, ensuring operational excellence and strategic alignment with business goals while driving continuous improv...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$116K - $155K *

Shape the future of HR technology by leading strategy, governance, and optimization of HRIS. Drive operational excellence, enhance user experience, and ensure compliance while managing a high-performi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Drive the successful delivery of complex industrial construction projects, ensuring alignment with budget, schedule, and safety standards while fostering strong client relationships and mentoring proj...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$78K - $113K *

Join us in transforming Revenue Cycle Management by leveraging analytical skills to enhance operational excellence across various RCM functions, driving process improvements and supporting financial p...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Oversee the design and development of clinical databases while ensuring project timelines and quality standards are met. Collaborate across teams to provide technical support and mentor team members...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $213K *

Lead a dynamic team to drive growth and operational excellence across Financial Products. Translate strategy into actionable plans, enhance customer experiences, and foster talent development while ac...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Empower a dedicated therapy team to enhance patient care and outcomes for adults and seniors. Lead with mentorship and support, fostering a collaborative environment while maintaining a strong focus o...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$185K - $312K *

Transform the Agentic Platform as a Principal PM, leading AI agent development across teams. Shape technical direction, enhance developer experience, and ensure seamless integration for impactful cust...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$120K - $193K *

Join a team that's redefining security product management by leading the strategy and delivery of innovative security solutions. Drive efficiency and compliance while enhancing developer experiences t...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $225K *

Join a dynamic team to drive growth and retention for US ISV partners across payments and money movement. Lead a team of account managers, design strategies, and enhance partner experiences to achieve...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$137K - $189K *

Drive the evolution of a premium streaming experience by leading product strategy, aligning consumer needs with business goals, and managing cross-functional teams to enhance engagement and retention...

2 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$125K - $150K *

Engage with policymakers and business leaders to drive revenue opportunities. Shape go-to-market strategies and government affairs initiatives, connecting teams to leverage policy insights for impactf...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$246K - $332K *

Transform the future of field operations by leading strategic initiatives that enhance commercial effectiveness and drive measurable impact across customer-facing teams. Collaborate with cross-functio...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$78K - $118K *

Join a team that's dedicated to enhancing Medicare Advantage products. You'll lead material reviews, ensure compliance, support operational readiness, and conduct competitor analysis to drive strategi...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Transform product capabilities by leading strategy and execution for shared workflows, ensuring seamless integration and user experience across platforms. Drive measurable outcomes through customer in...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Take ownership of financial planning and analysis for a sales territory, partnering with leadership to drive business decisions. Mentor analysts, enhance reporting tools, and elevate team performance...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Unlock financial insights as a strategic partner in real estate and facilities, driving planning, forecasting, and reporting. Collaborate cross-functionally to enhance operational efficiency and suppo...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$117K - $176K *

Empower your career by leading cross-functional teams to craft compelling narratives that drive strategic pursuits. Utilize your expertise in clinical development and storytelling to enhance customer...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Manage the operational backbone of multiple HCI portfolios by coordinating and executing initiatives, engaging with diverse stakeholders, and overseeing project timelines, budgets, and deliverables fo...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$111K - $167K *

Join a team that's driving healthcare transformation by leading client integration initiatives. Collaborate across departments to ensure seamless transitions, operational readiness, and long-term succ...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$168K - $281K *

Architect cutting-edge AI solutions as the design authority for Cyber Architecture. Lead a team of architects to define agentic frameworks and data fabric, ensuring robust AI/ML implementations across...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $164K *

Lead our cybersecurity and governance initiatives, enhancing security operations and risk management while driving compliance with CMMC 2.0 and ISO/IEC 27001 standards. Collaborate across teams to imp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Elevate client success by managing complex projects, ensuring timely delivery, and maintaining budget integrity. Collaborate with diverse teams to drive engagement and optimize project outcomes from i...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Engage with cross-functional teams to drive AI security product marketing initiatives, focusing on buyer insights, competitive analysis, and effective sales enablement. Collaborate on launches and con...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.