Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$110K - $140K *
Pioneer GxP compliance in digital quality management, ensuring software and AI products meet regulatory standards. Collaborate with stakeholders to enhance quality processes and support audits, drivin...
3 weeks ago
Senior Director, Engineering - Proactive Offense
$315K - $370K *
Join a team that's redefining offensive security by leading engineering efforts to transform research into scalable, customer-facing products. Drive strategy, execution, and innovation across multiple...
1 week ago
$100K - $120K *
Join our team to drive growth by reactivating lapsed accounts and expanding our advertising measurement solutions across various sectors. This sales-focused role combines prospecting and program manag...
Reposted 4 days ago
Senior Director Software Engineering
$286K - $326K *
Champion engineering excellence by leading high-performing teams to innovate scalable, customer-centric solutions. Drive technical strategy and architecture while fostering a culture of continuous lea...
3 weeks ago
Manager, Corporate Communications - Software
$81K - $128K *
Unlock potential by shaping integrated corporate communications strategies that connect software innovation with community impact, bridging B2B and B2C narratives to advance fraud prevention and eleva...
Reposted 1 week ago
Product Commercialization Manager
$91K - $121K *
Optimize the commercialization process by owning end-to-end management, collaborating across functions, and leveraging AI tools to enhance efficiency and scalability, ultimately driving data integrity...
Reposted 1 week ago
PLM (Centric/Flex) Functional Manager FY27
$141K - $278K *
Transform product lifecycle processes by delivering innovative PLM solutions. Collaborate with cross-functional teams to address complex challenges, drive efficiency, and enhance client operations acr...
3 days ago
PLM (Centric/Flex) Functional Manager FY27
$141K - $278K *
Join us to drive transformative Product Lifecycle Management solutions, collaborating with diverse teams to enhance operational efficiency and deliver impactful results across various industries, incl...
3 days ago
$110K - $130K *
Drive product strategy and execution for ConnectWise platforms, collaborating with cross-functional teams to enhance development, analyze market trends, and ensure effective solutions that align with...
1 week ago
Director of Tier 3 and Support Engineering
$125K - $150K *
Lead the charge in enhancing customer support by managing Tier 3 Support and Support Engineering teams. Drive technical resolutions, streamline escalations, and foster team development within a dynami...
3 weeks ago
$120K - $150K *
Join a dynamic team to shape corporate strategy by translating insights into actionable recommendations that drive growth. Collaborate cross-functionally to identify opportunities and influence decisi...
2 weeks ago
$120K - $135K *
Elevate our proposal management efforts by leading strategic submissions, fostering collaboration among teams, and enhancing our pursuit capabilities to secure high-value projects that improve infrast...
Reposted 1 week ago
$160K - $200K *
Join a team that's redefining product marketing in the insurance tech space. Lead strategic positioning, drive go-to-market initiatives, and empower teams with insights that connect product capabiliti...
3 days ago
Director, Operational Resilience
$136K - $168K *
Champion the evolution of an enterprise-wide Operational Resilience Framework, ensuring critical services persist during disruptions. Collaborate across teams to enhance governance, stakeholder alignm...
Yesterday
Senior Manager, Physical Therapy
$110K - $130K *
Lead the charge in optimizing physical therapy operations, enhancing care quality and access through strategic resource allocation and team development. Collaborate across clinical functions to drive...
1 week ago
Director, Early Talent, Claude Corps
$165K - $195K *
Accelerate the recruitment process for early-career talent, leading strategy and execution for cohort hiring. Collaborate across teams to ensure alignment and quality, while leveraging data and AI to...
3 days ago
Program Manager III, Employee Recognition & Engagement
$87K - $157K *
Champion enterprise employee recognition programs to enhance engagement, oversee design and implementation, manage multiple initiatives, and ensure alignment with organizational goals while fostering...
5 days ago
$73K - $97K *
Champion workforce optimization by overseeing staffing and operations, ensuring teams are equipped to deliver exceptional member experiences while fostering a supportive work environment...
5 days ago
Engineering Manager, Software Engineering (Java Backend)
$120K - $170K *
Join a team that's transforming digital services for Veterans by leading a skilled engineering group. You'll balance hands-on technical leadership with mentoring, driving the development of scalable J...
3 days ago
$110K - $125K *
Lead and develop a high-performing Solution Consulting team, driving strategic engagements and delivering impactful product demonstrations to agency and brokerage clients. Collaborate cross-functional...
3 weeks ago
$73K - $155K *
Unlock potential by leading change management initiatives in a dynamic Agile environment. Drive strategic improvements, enhance operational efficiency, and ensure system security while collaborating w...
6 days ago
DIRECTOR, HIGHER EDUCATION SECTOR FINANCE - NEW BUSINESS & RETENTION
$150K - $180K *
Drive financial strategy and execution for new business and client retention in the Higher Education Sector, optimizing revenue and profitability while collaborating with cross-functional teams to ens...
1 week ago
Manager, Home Center Analytics Enablement
$100K - $120K *
Transform data into actionable insights by leading analytics solutions that drive decision-making and improve performance. Collaborate across functions to establish trusted metrics and promote self-se...
4 weeks ago
GTM Strategy & Operations Manager- Special Projects
$147K - $211K *
Empower business leaders by driving strategic initiatives that enhance performance across Sales and Account Management. Utilize data-driven insights to translate complex challenges into actionable pla...
3 weeks ago
SVP, Head of Operational Risk Management
$294K - $443K *
Lead the development and execution of a global operational risk management strategy, ensuring alignment with business objectives and regulatory requirements while fostering a strong risk culture acros...
3 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.