Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$95K - $115K *

Optimize procurement processes and vendor management for industrial projects. Collaborate with teams to ensure timely delivery of equipment and materials, while maintaining compliance with safety and...

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$255K - $295K *

Optimize finance transformation strategies by leading enterprise-wide initiatives that unify processes, systems, and governance in a rapidly growing organization, enabling scalability and supporting l...

United StatesRemote

Reposted today

  •   11 - 15 years exp.  •   Technical Services

$177K - $221K *

Lead the development and execution of omnichannel content strategies, optimizing customer engagement across multiple platforms. Collaborate with cross-functional teams to enhance content operations, g...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion the execution of AI initiatives across the enterprise by overseeing project governance, planning, and cross-functional coordination, driving effective delivery from concept to measurable outc...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $185K *

Join a team that's driving strategic sourcing excellence in Facilities for Retail accounts. Lead a dedicated team to deliver innovative solutions, manage supplier relationships, and ensure high-qualit...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$125K - $150K *

Shape the future of preconstruction services by leading teams in cost analysis, estimate development, and project strategy for industrial power projects. Collaborate with stakeholders to ensure succes...

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$125K - $161K *

Unlock your potential by leading product development initiatives in healthcare supply chain. Collaborate across teams to define customer needs, drive innovation, and optimize workflows, ensuring impac...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$120K - $130K *

Manage enterprise-wide MarTech programs, aligning cross-functional teams to drive B2C marketing initiatives. Translate business priorities into actionable plans, ensuring effective collaboration and m...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$79K - $98K *

Join us to lead product management for our Medicare Part D program, ensuring compliance with CMS regulations while enhancing processes and client satisfaction. Your expertise will drive operational ex...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $192K *

Elevate operational excellence by leading process design and transformation initiatives. Drive automation, quality management, and continuous improvement to enhance client data operations and ensure s...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$182K - $303K *

Unlock strategic potential by leading NAPD's planning processes, aligning priorities, and driving execution across a complex healthcare landscape. Collaborate with senior leaders to shape decisions an...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive your career forward by leveraging advanced AI to enhance pricing programs. Join a new, dynamic team focused on building evaluations that ensure AI delivers value and accuracy, shaping the future...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$181K - $241K *

Take ownership of enterprise-wide risk management strategies, guiding executive leadership in navigating operational, financial, and construction risks. Collaborate across functions to enhance risk pr...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Energy & Utilities

$80K - $95K *

Reimagine project delivery by overseeing capital initiatives, ensuring alignment with standards while managing budgets, schedules, and stakeholder communication for successful outcomes in healthcare c...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$136K - $160K *

Advance the software delivery process by managing launches and releases, ensuring accuracy and efficiency through automation and collaboration with cross-functional teams. Design workflows and tools t...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Engage with clients to streamline communication, ensuring seamless project execution by coordinating cross-functional teams and aligning commitment with project goals, while proactively managing risks...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$207K - $267K *

Unlock potential by leading global procurement strategies, optimizing vendor management, and driving efficiency across technology and software categories while mentoring a high-performing team...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Media

$160K - $200K *

Optimize operational excellence and client service as a senior leader overseeing a complex Connected Solutions hub, ensuring high standards in production, technical operations, and team performance fo...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Media

$173K - $180K *

Unlock your potential by leading the strategic evolution of core infrastructure, ensuring secure and resilient technology services for a global workforce. Drive innovation and operational excellence w...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$119K - $199K *

Lead the charge in delivering exceptional service and maintenance solutions, managing customer relationships, and driving operational excellence in the power generation sector. Your expertise will enh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$170K - $180K *

Join us as a Technology Architect to shape and govern our Sales & Marketing tech ecosystem. Lead architecture design, drive integration strategies, and mentor teams to enhance client engagement and op...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$275K - $325K *

Drive the growth of healthcare practices by owning strategy, partnerships, and P&L. Collaborate with teams to deliver tailored financial solutions, while leveraging your network to establish Flex as t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$144K - $288K *

Lead the charge in transforming customer identity platforms, driving modernization and operational excellence while overseeing a multi-team engineering organization to enhance security and customer en...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $145K *

Lead the charge in strategic account management, driving growth and strengthening customer partnerships. Collaborate cross-functionally to align business objectives with customer needs while overseein...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$113K - $135K *

Innovate sourcing strategies and manage vendor relationships to optimize talent procurement services across various categories, ensuring alignment with business needs while enhancing cost efficiency a...

RemoteRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.