Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Develop strategic leadership for a team managing complex client portfolios, driving retention, growth, and client experience objectives while fostering strong relationships with stakeholders and ensur...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $250K *

Partner with us to lead transformative HR initiatives in a dynamic professional services environment. Shape talent strategies, drive AI integration, and build a robust People Services practice that su...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Business Services

$155K - $160K *

Drive the data and AI strategy by collaborating with clients, shaping predictive roadmaps, and translating complex problems into actionable product development, enhancing customer-facing analytics and...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$143K - $194K *

Pioneer innovative strategies for a Virtual First work stream, enhancing employee effectiveness through technology and research. Lead cross-functional initiatives, manage complex programs, and drive m...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$155K - $195K *

Engineer innovative civil solutions, managing projects from design to delivery. Lead a team in stormwater infrastructure and drainage planning while ensuring quality and client satisfaction across mul...

1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Oversee project delivery from preconstruction to closeout, ensuring compliance, safety, and quality in healthcare environments. Build strong relationships with stakeholders while managing budgets, sch...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Lead the execution of strategic initiatives across functions, ensuring alignment and standardization. Collaborate with leadership to drive performance visibility and enhance communication, fostering a...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$88K - $154K *

Optimize document management processes for a large-scale industrial project, ensuring accurate, secure, and accessible records throughout all project phases. Collaborate with multidisciplinary teams t...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $140K *

Champion the proposal process by leading submissions, coordinating resources, and ensuring strategic alignment. Drive improvements in proposal development while fostering collaboration across teams to...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Lead impactful partnerships to secure philanthropic investments, navigating complex relationships with high-net-worth individuals to drive climate solutions while ensuring integrity and transparency i...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$107K - $159K *

Transform organizational communication and engagement strategies to enhance Finance effectiveness, support leadership initiatives, and drive successful change management across the Global Finance orga...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $160K *

Join a dynamic team to drive integrated marketing strategies that enhance brand visibility and support business growth through innovative campaigns, digital activation, and thought leadership across m...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$107K - $159K *

Engage in strategic communication and change management to enhance Finance effectiveness. Collaborate with leadership to coordinate initiatives, support organizational engagement, and ensure clear mes...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Elevate clinical research by managing trials that showcase AI-enabled care pathways. Lead study execution, ensure compliance, and collaborate across teams to optimize project outcomes while enhancing...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $200K *

Accelerate progress at a multinational level by driving the reward and global mobility agenda. Lead the design and governance of compensation structures, ensuring alignment with business needs while p...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$206K - $309K *

Elevate the Analyst Experience by owning strategy and outcomes for security workflows. Lead a team of product managers to unify analyst tools, drive customer migrations, and enhance product vision, en...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$136K - $219K *

Lead the charge in optimizing sales operations and channel management, driving efficiency and revenue growth through strategic insights, team leadership, and cross-functional collaboration in a dynami...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Drive growth by building and scaling credit card acquisition channels through innovative affiliate partnerships, targeted paid search, and social programs, while collaborating with cross-functional te...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Reimagine project delivery by leading design teams and managing processes to ensure successful outcomes. Collaborate with stakeholders to create innovative solutions while maintaining compliance and q...

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$117K - $209K *

Own and optimize the end-to-end Procure-to-Pay function, ensuring seamless operations across Procurement, Accounts Payable, and supplier management while driving governance, performance, and stakehold...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$168K - $280K *

Optimize financial planning and analysis processes, driving strategic initiatives and enhancing reporting capabilities. Collaborate with leadership to deliver insights that support company-wide alignm...

RemoteRemote

3 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$144K - $220K *

Drive technical excellence as a Senior Staff Engineer, leading the Ops Portal team in shaping architecture and product direction across multiple platforms, while ensuring robust, scalable solutions fo...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Lead a dynamic team to enhance service delivery, drive employee development, and ensure high customer satisfaction while managing operational needs and fostering a positive organizational culture...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $140K *

Shape the future of federal financial operations by driving user adoption and change management for a new tool. Collaborate with stakeholders to enhance user experience, streamline processes, and ensu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.