Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$120K - $140K *

Join our team to shape innovative industrial solutions, driving product strategy and execution. You'll lead cross-functional efforts, ensuring compliance and safety while delivering impactful products...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$135K - $160K *

Transform our growth marketing strategy by driving demand generation and managing a high-performing team. Collaborate with cross-functional leaders to optimize pipeline performance and leverage automa...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Engage with clients and counsel to optimize document review processes, leveraging technology and analytics. Oversee project management, ensuring quality and efficiency while driving collaboration acro...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$92K - $110K *

Manage construction projects from planning to execution, ensuring safety, quality, and budget compliance. Collaborate with teams and clients to drive successful project delivery while maintaining stro...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Discover a pivotal leadership role in IT financial management, vendor governance, and technology optimization. Collaborate across departments to ensure technology investments yield value while managin...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$202K - $304K *

Shape operational strategies for complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development, budget creation, and client engagement, while mentoring c...

United StatesRemote

3 weeks ago

  •   15+ years exp.  •   Healthcare

$152K - $170K *

Lead the charge in optimizing global research operations, ensuring compliance and efficiency across diverse projects. Oversee strategic initiatives, manage resources, and collaborate with stakeholders...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$200K - $250K *

Shape the future of product strategy by leading cross-functional teams to drive customer outcomes and business results. Own the vision, roadmap, and execution while leveraging AI to enhance efficiency...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Transportation

$124K - $165K *

Lead complex $20M+ construction projects from preconstruction to closeout, managing teams, client relationships, and project delivery. Drive financial performance and mentor future leaders in a dynami...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$111K - $144K *

Optimize product strategies and drive development from concept to launch. Collaborate with cross-functional teams to align product vision with business goals, ensuring high-quality outcomes that meet...

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Transform project delivery by leading a dynamic team in Transmission Planning & Power Systems Analysis, ensuring high-quality consulting services and strategic alignment with organizational goals whil...

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$125K - $150K *

Accelerate progress at the forefront of financial planning and analysis, leading a team to enhance reporting efficiency and insights through AI-driven automation, while ensuring strategic alignment an...

Today

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$125K - $150K *

Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$182K - $325K *

Empower the GTM AI Engineering team by building innovative AI solutions that enhance sales and customer success workflows. Lead strategy and hands-on development, ensuring reliable, impactful AI produ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$180K - $230K *

Transform the future of platform strategy by leading Dynata+ to drive growth, enhance customer success, and establish a robust ecosystem. Oversee product development, P&L management, and enterprise-wi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$182K - $243K *

Shape the future of eCommerce by leading innovative health insurance solutions. Drive product strategy, enhance customer experiences, and collaborate across teams to deliver impactful results in a com...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Transform donor engagement by managing major gift prospects, cultivating relationships, and implementing strategic fundraising initiatives. Collaborate with campus units to enhance the philanthropic r...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Drive client success by enhancing revenue cycle performance and fostering strategic relationships with enterprise clients. Leverage expertise to implement solutions, manage risks, and ensure measurabl...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $198K *

Lead architectural vision for luxury developments, guiding projects from acquisition to delivery. Collaborate with teams to ensure design integrity and quality across the portfolio while advising exec...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $140K *

Join a dynamic team as you shape product strategy and drive innovation in assessment solutions. Collaborate with cross-functional teams to enhance user experiences and leverage emerging technologies f...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Drive total rewards strategy by managing compensation, benefits, and equity programs. Lead initiatives to ensure competitive, fair, and transparent offerings while supporting a growing workforce throu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Lead the charge in shaping and expanding bridge design services across New England. Provide strategic direction, oversee project delivery, mentor staff, and strengthen client relationships to enhance...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Unlock potential by leveraging your Salesforce expertise to design, build, and review secure, scalable solutions. Collaborate with clients and teams to ensure seamless integrations and effective deliv...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$111K - $150K *

Grow your career with a leadership role that shapes procurement strategies, drives supplier partnerships, and leads a high-performing sourcing team for SCADA and metering equipment in a dynamic engine...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$112K - $126K *

Join us to lead strategic investments in Service Engineering and Technical Publications, driving innovation through AI technologies. Collaborate with cross-functional teams to enhance product lifecycl...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.