Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Project Controls Manager and CPM Scheduler - Lake City Microgrid and CHP
$100K - $120K *
Transform project execution by developing and maintaining comprehensive CPM schedules, integrating multiple stakeholders, and ensuring timely updates to drive successful outcomes in large-scale indust...
2 weeks ago
Senior Manager, Facility Management (Americas)
$123K - $164K *
Shape the future of facility management by leading a $59M portfolio across North America and LATAM. Collaborate with cross-functional teams to ensure compliance, optimize budgets, and enhance service...
Reposted yesterday
$114K - $190K *
Engage with us to shape dynamic compensation strategies that drive enterprise growth, enhance employee engagement, and ensure compliance. Collaborate with HR leaders to tailor global rewards programs...
Reposted 3 days ago
$100K - $120K *
Join a team that's dedicated to advancing clinical trials by managing operations, analyzing data, and collaborating with diverse teams to ensure compliance and optimize outcomes for innovative treatme...
3 days ago
$100K - $120K *
Optimize clinical trial management by overseeing planning, execution, and compliance. Collaborate with cross-functional teams to ensure data integrity and drive innovative treatments while resolving c...
4 days ago
$100K - $120K *
Execute clinical trial management activities, ensuring quality outcomes and compliance. Collaborate with cross-functional teams, manage timelines and budgets, and build strong relationships with stake...
5 days ago
Sr. Director, Ideation Intelligence & Analytics
$197K - $271K *
Transform analytical discovery in healthcare payment integrity by leveraging advanced analytics, AI, and claims data to uncover savings opportunities and drive innovation across the organization, enha...
4 days ago
$110K - $130K *
Join a team that's redefining product management by building innovative features from concept to launch. Leverage AI tools to enhance efficiency and drive product operations, ensuring seamless deliver...
2 weeks ago
Senior Engineering Manager - GTM
$239K - $298K *
Discover a pivotal role in shaping the future of our engineering function. Lead a small team to enhance our GTM engine, integrating product and marketing efforts while driving innovation in technology...
1 week ago
Senior Implementation Project Manager - Healthcare Technology
$110K - $130K *
Lead the charge in complex software implementations for healthcare organizations, overseeing the full lifecycle from initiation to post-launch support while coordinating cross-functional teams and man...
4 weeks ago
$110K - $166K *
Optimize site contract management by reviewing, drafting, and negotiating various legal agreements. Collaborate with clinical teams to ensure timely deliverables and serve as a subject matter expert i...
1 week ago
$93K - $125K *
Manage a dynamic logistics engineering team to oversee comprehensive product support analysis, develop sustainment strategies, and maintain technical documentation to meet customer needs and enhance o...
Reposted 1 week ago
Manager, Device & Merchant Technology
$95K - $115K *
Help us manage the payment device lifecycle, ensuring optimal performance and compliance. Collaborate with teams and vendors to oversee configuration, fulfillment, and reporting, driving growth and en...
1 week ago
Manager, Device & Merchant Technology
$110K - $130K *
Optimize device lifecycle management by leading performance, strategy, and vendor relations. Collaborate with teams to ensure compliance and enhance merchant services while driving cost efficiency and...
1 week ago
Estimating Director (Electrical)
$120K - $145K *
Champion the estimating process for electrical scopes, ensuring client satisfaction and competitive estimates. Lead teams, develop strategies, and engage in business acquisition while fostering staff...
5 days ago
Manager, Client Delivery Experience (Output Solutions and Commercialization) - Remote
$105K - $163K *
Lead and manage client-facing teams to deliver high-quality card processing projects, ensuring successful implementations and client satisfaction through effective project management and strategic ove...
2 weeks ago
Senior Manager, AI Advisory and Open Source Program Office
$200K - $250K *
Unlock the potential of Open Source and AI governance by leading a multidisciplinary team to ensure compliance, drive best practices, and foster innovation across the enterprise, while collaborating w...
1 week ago
Digital Product Manager - Data Security
$120K - $193K *
Transform enterprise security by leading product strategy and delivery, focusing on data protection and compliance. Drive innovation through AI integration, ensuring scalable solutions that meet evolv...
3 weeks ago
Director - Global Sales Strategy
$125K - $250K *
Shape the future of global sales strategy by leading initiatives that drive partner growth and sales enablement. Collaborate with cross-functional teams to optimize processes, enhance capabilities, an...
3 weeks ago
Executive Operations Coordinator, Office of the COO
$180K - $220K *
Join a team that's redefining operational excellence by empowering the COO. You'll streamline communications, manage scheduling, and enhance productivity, enabling strategic focus and impactful decisi...
4 days ago
Senior Manager, Third Party Data Governance
$120K - $145K *
Shape the future of data governance by leading a team to manage third-party data compliance, ensuring operational excellence and regulatory adherence while fostering collaboration across business unit...
1 week ago
Director, Operational Excellence & Advanced Engineering (RE925)
$125K - $150K *
Drive enterprise-wide operational excellence and advanced engineering initiatives, enhancing manufacturing capabilities and performance. Collaborate with plant management to foster a culture of contin...
Today
Associate Director, Program Management Office, Global Medical Affairs - Solid Tumor Franchise
$148K - $198K *
Optimize global solid tumor medical initiatives by leading cross-functional teams, driving strategic planning, and enhancing operational efficiency within Medical Affairs. Collaborate with stakeholder...
Yesterday
$110K - $130K *
Transform data into actionable insights by mastering analytics across diverse domains. Collaborate with cross-functional teams to optimize reporting workflows and drive impactful solutions in a fast-p...
5 days ago
$160K - $200K *
Lead the design direction for Governance & Compliance, transforming complex workflows into seamless agent-driven experiences. Oversee a talented team, ensuring high-quality design while collaborating...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.