Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$135K - $210K *

Lead the charge in solving complex carrier connectivity challenges in commercial insurance. Collaborate with cross-functional teams to streamline workflows and enhance product delivery, ensuring seaml...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$142K - $237K *

Lead transformative initiatives in a strategic role, driving international business growth and operational excellence across regions and functions. Collaborate with senior stakeholders to implement a...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$90K - $170K *

Join a team that's driving strategic sales in TMS, WMS, and SaaS solutions. Lead initiatives to achieve sales targets, develop customer relationships, and promote innovative technology offerings while...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Transportation

$115K - $151K *

Transform technology operations by leading financial management, procurement, vendor oversight, and asset management. Drive strategic decision-making and operational excellence to enhance service deli...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$95K - $115K *

Transform business processes by leading SAP initiatives, enhancing operational efficiency, and driving continuous improvement across supply chain, manufacturing, and inventory management functions...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$154K - $278K *

Drive innovation in advanced maritime technologies, leading multidisciplinary teams to deliver cutting-edge solutions for critical defense missions. Oversee program execution, business development, an...

United StatesRemote

4 days ago

  •   15+ years exp.  •   Technical Services

$110K - $130K *

Lead EMR strategy and manage vendor relationships to drive operational excellence. Oversee the EMR Solution Specialist team, ensuring compliance and quality in system procedures while enhancing EMR su...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$148K - $263K *

Drive the design and implementation of AI-First operational environments, architecting resilient multi-cloud networks and building autonomous orchestration layers to enhance security and efficiency ac...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Grow your career with a dynamic team focused on enhancing knowledge management. Lead strategic initiatives, develop talent, and shape self-service experiences while collaborating across departments to...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$83K - $110K *

Lead operational excellence by managing complex training programs and enhancing processes for a statewide initiative, ensuring effective communication and client engagement while fostering a high-perf...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Elevate partner relationships in a strategic leadership role responsible for guiding a team and enhancing partner success through AI-driven workflows and high-touch service...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$108K - $135K *

Join a team that's driving innovation and operational excellence in digital services. This role involves project management, cross-functional collaboration, and strategic execution to ensure successfu...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$228K - $309K *

Drive impactful data science and engineering initiatives in Finance, leading a high-performing team to enhance decision-making through trusted data, advanced analytics, and AI capabilities while foste...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$77K - $101K *

Empower your career as you collaborate on innovative AI solutions, driving product delivery and operational excellence. Engage with cross-functional teams to enhance user experiences and support clien...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Business Services

$160K - $201K *

Lead the charge in shaping and evolving a global web ecosystem, overseeing strategy, operations, and governance to deliver high-performing digital experiences that drive engagement and business growth...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$181K - $208K *

Lead the charge in enterprise transformation and AI enablement, driving strategic initiatives and measurable outcomes through collaboration with cross-functional teams and senior leaders to enhance bu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the product lifecycle from concept to obsolescence, ensuring alignment with market needs and profitability. Collaborate cross-functionally to develop innovative products that drive growth and mee...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Transform your career by leading high-impact construction advisory services. Drive strategic client relationships, foster team collaboration, and innovate solutions to enhance project outcomes and pro...

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$160K - $200K *

Unlock potential by leading high-performing teams in construction disputes and advisory. Drive client relationships, innovate solutions, and ensure quality execution while fostering growth and collabo...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$93K - $150K *

Empower operational excellence by leading pilot implementations, engaging with customers, and translating insights into scalable solutions. Drive measurable outcomes while navigating complex environme...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Lead the charge in cloud security engineering by managing a team of experts to design and implement robust security controls across AWS, Azure, and GCP, ensuring compliance and operational excellence...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$68K - $120K *

Lead the charge in managing oncology clinical trials, ensuring efficient operations, compliance, and stakeholder engagement throughout the trial lifecycle while collaborating with various teams and ma...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$160K - $175K *

Transform client engagements by leading strategic planning, execution, and delivery across multiple projects. Ensure timely, high-quality outcomes while managing budgets, risks, and stakeholder expect...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Media

$110K - $130K *

Shape the future of higher education by leading complex SaaS modernization projects, aligning institutional goals with delivery execution, and fostering strong customer relationships to ensure success...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$218K - $256K *

Lead the charge in shaping IT strategy and operations for a remote-first SaaS company. Drive service delivery, enhance employee technology experiences, and build a high-performing IT organization whil...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.