Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Principal / Lead Product Manager, Carrier Connectivity
$135K - $210K *
Lead the charge in solving complex carrier connectivity challenges in commercial insurance. Collaborate with cross-functional teams to streamline workflows and enhance product delivery, ensuring seaml...
5 days ago
Director, International Business Transformation & Strategy Execution (flexible location)
$142K - $237K *
Lead transformative initiatives in a strategic role, driving international business growth and operational excellence across regions and functions. Collaborate with senior stakeholders to implement a...
1 week ago
Director, Strategic Sales(TMS, WMS & SaaS Focused)
$90K - $170K *
Join a team that's driving strategic sales in TMS, WMS, and SaaS solutions. Lead initiatives to achieve sales targets, develop customer relationships, and promote innovative technology offerings while...
Reposted 4 days ago
Senior Technology Operations Manager
$115K - $151K *
Transform technology operations by leading financial management, procurement, vendor oversight, and asset management. Drive strategic decision-making and operational excellence to enhance service deli...
1 week ago
Manager, Business Process (Hybrid)
$95K - $115K *
Transform business processes by leading SAP initiatives, enhancing operational efficiency, and driving continuous improvement across supply chain, manufacturing, and inventory management functions...
Yesterday
$154K - $278K *
Drive innovation in advanced maritime technologies, leading multidisciplinary teams to deliver cutting-edge solutions for critical defense missions. Oversee program execution, business development, an...
4 days ago
$110K - $130K *
Lead EMR strategy and manage vendor relationships to drive operational excellence. Oversee the EMR Solution Specialist team, ensuring compliance and quality in system procedures while enhancing EMR su...
2 days ago
$148K - $263K *
Drive the design and implementation of AI-First operational environments, architecting resilient multi-cloud networks and building autonomous orchestration layers to enhance security and efficiency ac...
Reposted 3 days ago
Director of Knowledge Management - NAMER
$135K - $160K *
Grow your career with a dynamic team focused on enhancing knowledge management. Lead strategic initiatives, develop talent, and shape self-service experiences while collaborating across departments to...
1 week ago
Children's Behavioral Health Training Operations Manager
$83K - $110K *
Lead operational excellence by managing complex training programs and enhancing processes for a statewide initiative, ensuring effective communication and client engagement while fostering a high-perf...
Reposted 2 weeks ago
$125K - $150K *
Elevate partner relationships in a strategic leadership role responsible for guiding a team and enhancing partner success through AI-driven workflows and high-touch service...
Reposted 3 weeks ago
Product Manager, Therapy Services Operations
$108K - $135K *
Join a team that's driving innovation and operational excellence in digital services. This role involves project management, cross-functional collaboration, and strategic execution to ensure successfu...
5 days ago
Director, Data Science & Engineering, Finance
$228K - $309K *
Drive impactful data science and engineering initiatives in Finance, leading a high-performing team to enhance decision-making through trusted data, advanced analytics, and AI capabilities while foste...
Yesterday
$77K - $101K *
Empower your career as you collaborate on innovative AI solutions, driving product delivery and operational excellence. Engage with cross-functional teams to enhance user experiences and support clien...
Reposted 4 days ago
$160K - $201K *
Lead the charge in shaping and evolving a global web ecosystem, overseeing strategy, operations, and governance to deliver high-performing digital experiences that drive engagement and business growth...
3 weeks ago
Director, Transformation & AI Enablement
$181K - $208K *
Lead the charge in enterprise transformation and AI enablement, driving strategic initiatives and measurable outcomes through collaboration with cross-functional teams and senior leaders to enhance bu...
1 week ago
$100K - $120K *
Lead the product lifecycle from concept to obsolescence, ensuring alignment with market needs and profitability. Collaborate cross-functionally to develop innovative products that drive growth and mee...
Yesterday
Managing Director, Construction Disputes & Advisory
$150K - $180K *
Transform your career by leading high-impact construction advisory services. Drive strategic client relationships, foster team collaboration, and innovate solutions to enhance project outcomes and pro...
4 weeks ago
Managing Director, Construction Disputes & Advisory
$160K - $200K *
Unlock potential by leading high-performing teams in construction disputes and advisory. Drive client relationships, innovate solutions, and ensure quality execution while fostering growth and collabo...
4 weeks ago
$93K - $150K *
Empower operational excellence by leading pilot implementations, engaging with customers, and translating insights into scalable solutions. Drive measurable outcomes while navigating complex environme...
2 days ago
Manager, Cloud Security Engineering
$125K - $150K *
Lead the charge in cloud security engineering by managing a team of experts to design and implement robust security controls across AWS, Azure, and GCP, ensuring compliance and operational excellence...
1 week ago
Clinical Trials Project Manager
$68K - $120K *
Lead the charge in managing oncology clinical trials, ensuring efficient operations, compliance, and stakeholder engagement throughout the trial lifecycle while collaborating with various teams and ma...
Reposted 3 days ago
$160K - $175K *
Transform client engagements by leading strategic planning, execution, and delivery across multiple projects. Ensure timely, high-quality outcomes while managing budgets, risks, and stakeholder expect...
Yesterday
Sr. Project Manager - Higher Education ERP & SaaS, Remote-United States
$110K - $130K *
Shape the future of higher education by leading complex SaaS modernization projects, aligning institutional goals with delivery execution, and fostering strong customer relationships to ensure success...
1 week ago
$218K - $256K *
Lead the charge in shaping IT strategy and operations for a remote-first SaaS company. Drive service delivery, enhance employee technology experiences, and build a high-performing IT organization whil...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.