Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$110K - $130K *

Drive strategic growth by managing projects, fostering client relationships, and ensuring timely delivery within budget. Lead teams, negotiate contracts, and represent the company in meetings to achie...

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Lead the charge in managing complex ERP implementation projects, ensuring alignment between customer needs and internal resources. Drive project success through effective communication, risk managemen...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Take ownership of MEP project management, ensuring seamless execution of mechanical, electrical, and plumbing systems on complex commercial and industrial projects while collaborating with diverse tea...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$107K - $195K *

Join a team that's dedicated to enhancing national security through innovative project management. You'll lead cross-functional teams in a fast-paced Agile environment, ensuring timely delivery of sof...

2 days ago

  •   5 - 7 years exp.  •   Technical Services

$90K - $150K *

Oversee and manage a hyper-scale data center project by collaborating with stakeholders, ensuring effective budget control, and driving safety and productivity on site, while fostering strong communic...

Reposted today

  •   8 - 10 years exp.  •   Staffing

$92K - $115K *

Drive successful client implementations by managing projects from inception to deployment. Collaborate cross-functionally to ensure timely, on-budget delivery while interfacing with stakeholders and v...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$111K - $163K *

Join a team dedicated to driving successful IT project outcomes through effective management methodologies, ensuring on-time and on-budget completion while aligning with business goals and fostering c...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $135K *

Lead the charge in driving strategic project delivery across multiple squads, ensuring alignment with business priorities and effective communication among stakeholders. Utilize program management exp...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$160K - $200K *

Lead the charge in optimizing top-of-funnel marketing operations, driving measurable pipeline growth through strategic planning, data governance, and team leadership. Collaborate with cross-functional...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead strategic initiatives by managing complex projects from inception to launch. Collaborate across teams to implement new markets and contracts, ensuring compliance and operational readiness in a dy...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $129K *

Join a dynamic team as you lead internal and corporate communications, crafting clear, engaging messages that align with company goals. Drive change management and enhance employee engagement through...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Elevate project outcomes by managing complex initiatives, leading teams, and ensuring stakeholder alignment. Drive quality improvement and change management while fostering collaboration to achieve st...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Drive successful public-sector construction projects by managing scope, schedule, and budget while fostering strong client relationships and ensuring quality delivery from inception to closeout...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$108K - $130K *

Lead the charge in executing integrated design projects, guiding a multi-disciplinary team to meet client objectives while ensuring quality, budget, and schedule alignment across diverse industries...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$104K - $130K *

Lead project management efforts in mission-critical environments, overseeing design and construction phases. Collaborate with diverse teams, manage budgets, and ensure client satisfaction while drivin...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Technical Services

$125K - $150K *

Champion digital transformation by leading delivery teams in Salesforce projects, ensuring excellence in project management, client relationships, and issue resolution while mentoring consultants and...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$103K - $181K *

Optimize document control processes by leading the Information Branch, ensuring accurate and accessible records management for a major industrial program while coordinating with various stakeholders a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$126K - $162K *

Join a dynamic team to lead construction administration projects, ensuring seamless execution from design to closeout. Collaborate with stakeholders, manage client relations, and drive project success...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$145K - $175K *

Transform your career by leading cross-functional teams to drive drug development strategies. Collaborate with key stakeholders to ensure successful execution of integrated plans, manage risks, and de...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Accelerate progress at the forefront of digital transformation by leading strategic initiatives, ensuring effective governance, and driving organizational change across global teams to enhance program...

RemoteRemote

5 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Lead a dynamic team to enhance client partnerships, driving retention and growth for Fortune 500 and global clients. Your leadership will shape strategies, oversee renewals, and ensure exceptional ser...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $195K *

Drive change management initiatives that enhance employee engagement and operational efficiency. Collaborate across teams to ensure successful adoption of technology and policy changes, while providin...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $94K *

Shape exceptional client experiences by leading AV production and design projects. Collaborate across sectors to ensure successful event execution while building lasting relationships and maintaining...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$100K - $120K *

Accelerate progress at a leading telecom program by driving automation in engineering activities. Collaborate with cross-functional teams to deliver innovative solutions while managing scope, timeline...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Staffing

$107K - $145K *

Drive success by managing complex technology construction projects, optimize resources, ensure client satisfaction, and lead teams to achieve high quality and productivity in project completion. Trave...

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.