Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$150K - $180K *

Pioneer the development of innovative technology solutions, driving product strategy and AI integration to enhance operational efficiency and customer experience across the insurance lifecycle. Lead a...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $175K *

Transform investment research by evaluating and integrating diverse datasets, enhancing AI-driven workflows, and driving strategic content initiatives to elevate platform value and user experience...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$200K - $300K *

Champion strategic bank capital relationships, driving coverage and capital formation across diverse financial products. Collaborate with teams to enhance bank participation and manage relationships...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$183K - $228K *

Drive strategic financial insights as a key partner to the go-to-market teams, owning revenue forecasts and investment economics. Collaborate with leadership to shape long-term growth strategies and e...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Transform the Workday platform by leading strategic governance, optimization, and integration efforts. Collaborate with cross-functional teams to enhance system performance, ensure data integrity, and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$100K - $130K *

Support the financial planning and analysis for Executive Leadership, encompassing budgeting, forecasting, and reporting. Collaborate cross-functionally to drive profitability through data-driven insi...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$138K - $214K *

Optimize project outcomes by leading preconstruction efforts for large-scale Data Center initiatives. Drive team performance, manage budgets, and ensure exceptional client relationships while overseei...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$138K - $214K *

Shape the future of data center projects by leading preconstruction efforts, ensuring optimal financial positioning, and fostering strong team collaboration to deliver exceptional results and client s...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Shape the future of healthcare by leading complex architectural and facility projects, ensuring optimal client service and regulatory compliance throughout all project phases while guiding multidiscip...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$160K - $180K *

Lead organizational capability by bridging strategy and execution across diverse hospitality operations. Drive scalable frameworks and change management to enhance performance and sustain innovation a...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$125K - $150K *

Champion strategic preconstruction initiatives across industrial sectors, leading estimating, budgeting, and design coordination. Collaborate with clients and stakeholders to ensure project success fr...

Reposted today

  •   8 - 10 years exp.  •   Real Estate & Construction

$223K - $334K *

Lead the charge in establishing investigation excellence and reliability engineering capabilities. Collaborate globally to enhance quality outcomes, drive data-driven decisions, and mentor technical e...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Transform your career by leading IT operations and team development, enhancing service delivery, and managing technology solutions for a dynamic workforce. Drive improvements and ensure seamless suppo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $295K *

Lead the development of innovative AI-enabled Amazon Commerce solutions, transforming complex data into actionable insights. Collaborate with cross-functional teams to create scalable offerings that e...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Media

$120K - $193K *

Accelerate progress at the intersection of security and technology by leading integration product management for enterprise security capabilities across multiple business units, ensuring streamlined a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$113K - $176K *

Lead procurement efforts for large-scale gas generation and renewable projects, ensuring alignment with project timelines and budgets. Manage a team, oversee supply chain activities, and drive process...

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$165K - $175K *

Unlock potential by leading enterprise data engineering initiatives, driving platform modernization, and enhancing operational excellence. Collaborate with cross-functional teams to deliver scalable...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$190K - $275K *

Advance the Data & Distribution Partnerships function by innovating and scaling data reseller and distribution models, building commercial arrangements, and leading a team to create revenue-generating...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in transforming construction management through digital delivery. Collaborate with leadership to set strategic direction, enhance project efficiency, and drive innovation across teams...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$120K - $145K *

Drive impactful program management by leading cross-functional initiatives, ensuring alignment with strategic goals, and delivering measurable results in a dynamic environment. Collaborate effectively...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$175K - $220K *

Join a team that's shaping infrastructure projects through expert scheduling leadership. Your strategic planning and risk management skills will optimize resource use and ensure timely delivery in a c...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$205K - $240K *

Shape the future of supply chain technology by leading engineering teams in optimizing platforms for logistics and order management. Drive innovation and efficiency while managing a diverse team of ex...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$88K - $105K *

Unlock potential by leading complex programs, fostering collaboration across teams, and enhancing profitability while ensuring customer satisfaction. Grow your career with proven experience in program...

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$107K - $199K *

Elevate operational excellence by leading Enterprise Business Operations, ensuring compliance and continuous improvement while fostering collaboration across stakeholders to drive strategic initiative...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$137K - $210K *

Lead the profitability and risk strategy for a diverse Asset Protection portfolio. Shape underwriting governance and drive data-informed decisions to enhance product performance across multiple market...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.