Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$123K - $207K *

Champion the design and ownership of a robust People Data Access & Governance framework, ensuring responsible data access while partnering with cross-functional teams to navigate compliance and ethica...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$128K - $178K *

Lead the evolution of our CMS and AI web strategy, driving product vision and execution for public sector clients. Collaborate with cross-functional teams to deliver innovative, customer-focused solut...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$90K - $110K *

Engage with us to lead the proposal development lifecycle, ensuring compliance and quality in federal government submissions. Collaborate with diverse teams to drive success in a dynamic small busines...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$103K - $123K *

Drive growth by managing a sales territory, building relationships, and generating premium. Leverage existing partnerships while prospecting new agencies to achieve targets and expand market presence...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$180K - $230K *

Grow your career with a leadership role overseeing global operations, focusing on strategy development, performance management, and cross-department collaboration to drive operational excellence and i...

RemoteRemote

Reposted today

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$127K - $203K *

Champion the AI Center of Excellence by managing the roadmap, prioritizing initiatives, and ensuring alignment with corporate goals. Drive stakeholder engagement and deliver measurable business outcom...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in expanding and retaining enterprise client relationships, driving revenue growth and strategic account management across regions. Develop and mentor a high-performing account team to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$178K - $294K *

Join a team that's redefining data engineering and analytics. Lead strategy, architecture, and execution of scalable data solutions while mentoring professionals and driving business outcomes through...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$185K - $297K *

Lead the execution of innovative onboarding strategies, driving customer success through insights and support resolution. Collaborate with cross-functional teams to enhance product utilization and def...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$203K - $345K *

Elevate product strategy for SaaS platforms, driving growth and operational excellence. Connect technical capabilities with business outcomes while enhancing customer experience and scalability across...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Healthcare

$116K - $157K *

Drive program success by leading cross-functional teams in executing IRAD efforts, ensuring alignment with technical, cost, and schedule goals from concept to transition, while fostering collaboration...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$216K - $318K *

Champion the evolution of AI Platforms, leading a dynamic team to enhance AI integration and productivity. Drive strategic initiatives that empower engineers and elevate member experiences through inn...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$70K - $126K *

Elevate your career by leading enterprise Performance Development initiatives. Collaborate across teams to enhance performance conversations, drive data-informed decisions, and ensure program success...

Missouri, USRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Lead and manage design-build projects, ensuring timely completion within budget while meeting client objectives and contractual obligations. Oversee scope development, financial performance, and compl...

United StatesRemote

Reposted 3 days ago

  •   15+ years exp.  •   Transportation

$80K - $95K *

Manage land development projects from design to construction, collaborating with clients and stakeholders to create effective site plans and ensure compliance with regulations. This role offers growth...

3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$135K - $160K *

Advance clinical trial execution by leading cross-functional teams, ensuring timely delivery of innovative therapies. Collaborate with stakeholders to navigate product life cycles from concept to comm...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$124K - $224K *

Unlock potential by leading revenue operations, bridging sales, finance, and analytics. Drive forecasting, pipeline management, and team development to enhance business performance and ensure data int...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$75K - $100K *

Elevate your career by leading residential capital projects from inception to completion. Collaborate with cross-functional teams to ensure timely, budget-friendly delivery of managed WiFi solutions w...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$70K - $105K *

Collaborate with cross-functional teams to drive project execution and operational excellence in medical communications. Leverage your project management skills to ensure timely delivery and high-qual...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$134K - $209K *

Lead the product strategy and delivery for a comprehensive Workday ecosystem. Manage a team of product managers to enhance HR capabilities, ensuring alignment with enterprise priorities and improving...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Contribute to quality operations initiatives by reviewing study documents, supporting audits, and ensuring compliance with regulatory standards. Collaborate with cross-functional teams to enhance qual...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$172K - $287K *

Join us to shape the future of pharmacy by leading product strategy and innovation. Drive growth and commercialization for a diverse portfolio of healthcare technology solutions, influencing enterpris...

RemoteRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$157K - $183K *

Unlock innovative Finance and Accounting outsourcing solutions by leading design and development efforts. Collaborate with cross-functional teams to optimize service delivery and drive strategic clien...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Business Services

$184K - $324K *

Unlock your potential in this leadership role, where you'll drive product strategy and team excellence. Collaborate with cross-functional partners to enhance the consumer experience and deliver impact...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.