Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Program Manager, People Data Access & Governance
$123K - $207K *
Champion the design and ownership of a robust People Data Access & Governance framework, ensuring responsible data access while partnering with cross-functional teams to navigate compliance and ethica...
Reposted 2 weeks ago
Manager, Product Management - Content Management Systems
$128K - $178K *
Lead the evolution of our CMS and AI web strategy, driving product vision and execution for public sector clients. Collaborate with cross-functional teams to deliver innovative, customer-focused solut...
2 weeks ago
$90K - $110K *
Engage with us to lead the proposal development lifecycle, ensuring compliance and quality in federal government submissions. Collaborate with diverse teams to drive success in a dynamic small busines...
1 week ago
$103K - $123K *
Drive growth by managing a sales territory, building relationships, and generating premium. Leverage existing partnerships while prospecting new agencies to achieve targets and expand market presence...
2 weeks ago
$180K - $230K *
Grow your career with a leadership role overseeing global operations, focusing on strategy development, performance management, and cross-department collaboration to drive operational excellence and i...
Reposted today
$127K - $203K *
Champion the AI Center of Excellence by managing the roadmap, prioritizing initiatives, and ensuring alignment with corporate goals. Drive stakeholder engagement and deliver measurable business outcom...
Yesterday
$150K - $180K *
Lead the charge in expanding and retaining enterprise client relationships, driving revenue growth and strategic account management across regions. Develop and mentor a high-performing account team to...
1 week ago
Director, Data Engineering & Analytics
$178K - $294K *
Join a team that's redefining data engineering and analytics. Lead strategy, architecture, and execution of scalable data solutions while mentoring professionals and driving business outcomes through...
Reposted 3 weeks ago
Group Product Manager, Onboarding & Agentic Success
$185K - $297K *
Lead the execution of innovative onboarding strategies, driving customer success through insights and support resolution. Collaborate with cross-functional teams to enhance product utilization and def...
2 days ago
Director of Product Management, Platforms
$203K - $345K *
Elevate product strategy for SaaS platforms, driving growth and operational excellence. Connect technical capabilities with business outcomes while enhancing customer experience and scalability across...
Yesterday
Senior Principal, Business Management
$135K - $160K *
Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...
Reposted 5 days ago
$116K - $157K *
Drive program success by leading cross-functional teams in executing IRAD efforts, ensuring alignment with technical, cost, and schedule goals from concept to transition, while fostering collaboration...
Reposted 1 week ago
$216K - $318K *
Champion the evolution of AI Platforms, leading a dynamic team to enhance AI integration and productivity. Drive strategic initiatives that empower engineers and elevate member experiences through inn...
3 weeks ago
Program Manager II, Performance Development
$70K - $126K *
Elevate your career by leading enterprise Performance Development initiatives. Collaborate across teams to enhance performance conversations, drive data-informed decisions, and ensure program success...
Yesterday
Sr. Design-Build Project Manager
$125K - $150K *
Lead and manage design-build projects, ensuring timely completion within budget while meeting client objectives and contractual obligations. Oversee scope development, financial performance, and compl...
Reposted 3 days ago
Civil Engineering Project Manager
$80K - $95K *
Manage land development projects from design to construction, collaborating with clients and stakeholders to create effective site plans and ensure compliance with regulations. This role offers growth...
3 weeks ago
Associate Director/Director, Clinical Program Management
$135K - $160K *
Advance clinical trial execution by leading cross-functional teams, ensuring timely delivery of innovative therapies. Collaborate with stakeholders to navigate product life cycles from concept to comm...
3 days ago
$124K - $224K *
Unlock potential by leading revenue operations, bridging sales, finance, and analytics. Drive forecasting, pipeline management, and team development to enhance business performance and ensure data int...
1 week ago
$75K - $100K *
Elevate your career by leading residential capital projects from inception to completion. Collaborate with cross-functional teams to ensure timely, budget-friendly delivery of managed WiFi solutions w...
3 days ago
Program Manager, Medical Communications
$70K - $105K *
Collaborate with cross-functional teams to drive project execution and operational excellence in medical communications. Leverage your project management skills to ensure timely delivery and high-qual...
2 weeks ago
Lead Digital Product Manager (Workday)
$134K - $209K *
Lead the product strategy and delivery for a comprehensive Workday ecosystem. Manage a team of product managers to enhance HR capabilities, ensuring alignment with enterprise priorities and improving...
1 week ago
Quality Operations Manager (Contract)
$100K - $120K *
Contribute to quality operations initiatives by reviewing study documents, supporting audits, and ensuring compliance with regulatory standards. Collaborate with cross-functional teams to enhance qual...
1 week ago
Senior Director Product Management
$172K - $287K *
Join us to shape the future of pharmacy by leading product strategy and innovation. Drive growth and commercialization for a diverse portfolio of healthcare technology solutions, influencing enterpris...
Reposted 2 weeks ago
Senior Director, Business Solution Architecture
$157K - $183K *
Unlock innovative Finance and Accounting outsourcing solutions by leading design and development efforts. Collaborate with cross-functional teams to optimize service delivery and drive strategic clien...
3 days ago
Director, Product Management, Consumer (Top-Funnel)
$184K - $324K *
Unlock your potential in this leadership role, where you'll drive product strategy and team excellence. Collaborate with cross-functional partners to enhance the consumer experience and deliver impact...
Reposted 3 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.