Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$100K - $140K *

Lead the charge in driving revenue growth and client retention by managing strategic relationships and optimizing operational strategies for a diverse portfolio of enterprise clients in the transporta...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Transportation

$95K - $115K *

Develop and lead VDC processes and best practices, managing resources across projects. Collaborate with teams to enhance virtual building culture and ensure effective execution throughout the project...

St. Louis, MORemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$88K - $105K *

Lead a dynamic team in overseeing sewer and drainage project reviews, ensuring compliance and strategic alignment with district goals while fostering collaboration with public officials and stakeholde...

Yesterday

  •   8 - 10 years exp.  •   Energy & Utilities

$169K - $255K *

Shape the future of personalized consumer products by driving strategic partnerships and revenue growth. Lead business development efforts, cultivate relationships, and expand market reach to position...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$169K - $255K *

Join a team that's driving growth through strategic partnerships in personalized consumer products. Lead initiatives to expand market reach and revenue streams while collaborating across functions to...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$202K - $253K *

Elevate your leadership as you drive engineering excellence, overseeing multiple squads from prototype to production. Shape the roadmap, empower teams, and ensure quality delivery while staying techni...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Transform construction project delivery by managing all phases, ensuring timely, budget-friendly, and quality outcomes. Collaborate with cross-functional teams to align solutions with business needs a...

1 week ago

  •   8 - 10 years exp.  •   Transportation

$110K - $130K *

Drive CQV excellence for capital projects in a GMP-regulated environment, ensuring compliance and timely execution. Lead teams through commissioning, qualification, and operational handover of critica...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $113K *

Manage project lifecycles to exceed client expectations, ensuring timely communication and risk management while fostering collaboration and mentoring within teams to achieve project goals and profita...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$95K - $113K *

Manage project lifecycles to exceed client expectations, ensuring timely communication and risk management. Foster collaboration across teams, mentor peers, and uphold safety and quality standards whi...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$120K - $150K *

Transform complex data center projects by leading design and construction efforts. Collaborate with diverse stakeholders to ensure successful project delivery while managing multiple initiatives acros...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$180K - $240K *

Drive cross-domain visibility and coordination in a dynamic engineering environment. As the sole TPM, you'll ensure programs are on track, dependencies are mapped, and automation enhances efficiency a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Join our dynamic team as a Finance Manager, where you'll lead financial analysis, develop models, and present insights to senior leadership, driving growth and accuracy in financial reporting across t...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Empower consumer experiences by leading product strategy and execution for innovative genomics solutions. Collaborate with cross-functional teams to enhance user satisfaction and drive adoption throug...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$103K - $185K *

Join a team that's focused on hands-on technical delivery while mentoring and developing team capabilities. Lead solution implementation, troubleshoot issues, and establish best practices to ensure hi...

1 week ago

  •   Less than 5 years exp.  •   Business Services

$161K - $190K *

Transform the digital commerce experience by owning a high-velocity experimentation roadmap. Collaborate across teams to enhance customer journeys, improve conversion rates, and establish a robust exp...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $195K *

Elevate client relationships by managing key accounts, driving satisfaction and growth. Collaborate with internal teams to deliver tailored solutions, ensuring long-term success and measurable ROI for...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Engineer innovative data products that empower global businesses. Lead cross-functional teams to define product strategy, manage lifecycles, and drive performance metrics, ensuring alignment with mark...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $219K *

Engage with customers to identify key challenges and drive product innovation. Collaborate across hardware, software, and AI teams to deliver impactful solutions that enhance physical operations and g...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$124K - $280K *

Elevate client data governance by leading SAP MDG initiatives, enhancing master data quality, and aligning processes. Guide teams through complex transformations while delivering strategic recommendat...

Yesterday

  •   5 - 7 years exp.  •   Legal & Accounting

$124K - $280K *

Champion SAP data governance initiatives, guiding teams to enhance master data quality and streamline processes. Leverage your expertise to drive client success in complex transformation programs whil...

Yesterday

  •   5 - 7 years exp.  •   Legal & Accounting

$110K - $130K *

Optimize program delivery by leading complex projects from proposal to execution. Drive cross-functional collaboration, manage budgets, and ensure customer commitments are met while mentoring junior p...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$100K - $120K *

Lead document review projects by optimizing workflows and technology. Collaborate with counsel and internal teams to ensure quality and efficiency in deliverables, driving down costs while enhancing a...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$120K - $145K *

Oversee global EPC proposal processes for Battery Energy Storage Systems, collaborating with cross-functional teams to deliver innovative, customer-centric solutions while driving continuous improveme...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$125K - $145K *

Unlock potential by leading complex multi-disciplinary projects to achieve client goals, overseeing contracting, risk management, and deliverable production, while supporting program growth and commun...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.