Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$100K - $120K *

Champion the proposal management process by leading complex RFP responses, ensuring compliance and quality. Collaborate with cross-functional teams to deliver compelling proposals that align with stra...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$141K - $234K *

Lead the charge in healthcare performance improvement by overseeing project delivery, managing client relationships, and mentoring a team of Advisory consultants to ensure successful, high-quality out...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Drive impactful data strategies and analytics by leading a high-performing team, optimizing decision-making, and enhancing operational efficiency across the organization. Collaborate with stakeholders...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$267K - $360K *

Drive impactful consumer journeys by leading product growth initiatives that enhance engagement and revenue. Collaborate across teams to optimize experiences while mentoring a high-performing product...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $122K *

Unlock your potential as you lead financial planning, analytics, and strategic initiatives. Collaborate closely with executives to drive performance improvements and optimize resource allocation, fost...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $188K *

Drive operational risk enablement across regions by translating enterprise frameworks, building practitioner capabilities, and ensuring compliance with local regulations while fostering strong stakeho...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $110K *

Grow your career with a pivotal role in configuration management, ensuring system stability and compliance. Collaborate across teams to track changes, maintain documentation, and support deployments i...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $180K *

Innovate with us as you lead technical delivery for enterprise data integration and migration projects, focusing on Higher Education and Salesforce ecosystems. Drive solution architecture, manage team...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $150K *

Elevate your career by leading strategic initiatives in enterprise systems. Drive operational excellence, enhance data integration, and champion modern processes to support institutional priorities an...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$114K - $187K *

Optimize clinical data management processes by leading teams and ensuring compliance with standards. Collaborate with stakeholders to enhance data quality and streamline operations across multiple com...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Optimize supply chain strategies to enhance material availability and production readiness. Lead cross-functional teams in planning, inventory management, and compliance, driving continuous improvemen...

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$255K - $310K *

Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$105K - $150K *

Transform healthcare insights by leading client engagements with real-world data. Drive business development and project delivery while building long-term client relationships in a dynamic, hybrid wor...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$63K - $108K *

Join a team that's driving project success by managing multiple HVAC control projects. Oversee budgets, schedules, and client relationships while ensuring quality delivery and continuous improvement i...

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$115K - $171K *

Champion strategic growth by leading analyses that drive international expansion and acquisitions. Collaborate with senior leaders to shape decisions and deploy AI agents for enhanced efficiency in a...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$117K - $156K *

Shape the future of clinical trials by managing the execution and oversight of Class III medical device studies. Collaborate with teams and ensure compliance, quality standards, and operational succes...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Shape the future of health programs as a strategic leader in monitoring and evaluation. Leverage analytics to optimize data systems and drive innovation across diverse projects, ensuring alignment wit...

RemoteRemote

Reposted today

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Champion cross-functional projects to enhance operational efficiency and achieve organizational goals. Lead initiatives from planning to completion, ensuring timely delivery within scope and budget wh...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $90K *

Transform your career with impactful auditing and training roles in risk adjustment. Collaborate with management to enhance coding compliance, drive performance improvement, and foster a culture of ex...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $140K *

Champion supply chain excellence by leading procurement activities for construction projects, ensuring alignment with schedules, budgets, and quality standards while mentoring specialists and driving...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $145K *

Empower operational excellence by leading continuous improvement initiatives across manufacturing facilities. Collaborate with cross-functional teams to enhance safety, quality, and productivity while...

3 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Take ownership of operational assessments to enhance effectiveness, identify risks, and drive performance improvements across functions. Collaborate with leaders to align practices with strategic goal...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $108K *

Champion high-impact strategic initiatives, collaborating with executives to drive alignment and measurable results across the organization while navigating complexity and change...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $140K *

Lead the charge in driving revenue growth and client retention by managing strategic relationships and optimizing operational strategies for a diverse portfolio of enterprise clients in the transporta...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Transportation

$95K - $115K *

Develop and lead VDC processes and best practices, managing resources across projects. Collaborate with teams to enhance virtual building culture and ensure effective execution throughout the project...

St. Louis, MORemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.