Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$104K - $155K *

Lead the charge in customer-focused project management, ensuring effective delivery of technical solutions while coordinating with diverse stakeholders and fostering strong relationships for successfu...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$192K - $303K *

Empower innovation as you lead the strategy and development of core platform primitives, driving the future of agentic systems and ensuring product teams can rapidly create and deploy advanced agents...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$191K - $260K *

Drive ERP strategy and modernization initiatives, collaborating with leaders to ensure technology investments yield significant business value and enhance operational efficiency across the organizatio...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$115K - $275K *

Manage the delivery of GPU clusters for AI workloads by coordinating teams across engineering, networking, and operations. Develop strategies, manage risks, and ensure timely, quality launches to scal...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $200K *

Empower partner operations by leading strategy, optimizing processes, and enhancing tools for a diverse global partner ecosystem. Collaborate cross-functionally to ensure scalable infrastructure and m...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $186K *

Transform procurement strategies by leading vendor management and building strategic partnerships. Drive operational efficiency while optimizing spend and enhancing supplier performance to support lon...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $120K *

Execute comprehensive program management for a critical Air Force contract, leading a diverse team to ensure compliance, quality, and performance across multiple global operations while maintaining 24...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$115K - $135K *

Join a team that's transforming Medicaid agencies through expert OCM strategies. Leverage your project management and change management skills to enhance health outcomes and build stronger communities...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$190K - $220K *

Drive exceptional service delivery and operational excellence as you lead a high-performing facilities management team across multiple locations, focusing on customer satisfaction and financial perfor...

St. Louis, MORemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$104K - $143K *

Join a team that's driving strategic cybersecurity initiatives to enhance security posture, reduce risk, and achieve compliance. Collaborate across technical and business domains to ensure successful...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Contribute to impactful consulting services in government pricing, leveraging your expertise to guide clients through compliance, data analysis, and strategic initiatives while leading a collaborative...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Join us in shaping the future of Fair Lending solutions. Drive product strategy, deliver expert analysis, and enhance client outcomes while navigating complex regulatory landscapes. Your expertise wil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $95K *

Elevate your career by leading construction projects from concept to completion. Oversee planning, budgeting, and execution while ensuring safety and quality standards are met. Collaborate with divers...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$198K - $298K *

Elevate your career by leading global investigator grants strategy and operations. Drive integration, governance, and financial controls while collaborating with cross-functional teams to ensure compl...

United StatesRemote

Today

  •   15+ years exp.  •   Healthcare

$145K - $175K *

Join a team that's redefining AI-driven solutions by leading product development for an innovative tech concierge. Drive the evolution of agent capabilities, ensuring quality and reliability while col...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Optimize engagement and monetization strategies for an AI-driven product, transforming customer interactions into measurable growth. Lead cross-functional teams to innovate and implement effective use...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $115K *

Transform your career by leading financial strategy and operations for innovative service lines. Collaborate with senior leaders to enhance profitability, oversee budgeting, and drive growth initiativ...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Transform global partner strategies to drive revenue and market share through innovative go-to-market models, collaborating with key stakeholders to establish impactful partnerships and optimize sales...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$180K - $200K *

Accelerate progress at regional Professional Services by leading teams, driving growth and quality in consulting engagements while fostering strategic partnerships and developing innovative service of...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$95K - $150K *

Pioneer the future of HR technology by leading cross-functional teams to define and deliver innovative solutions in Global Mobility and Talent Management, ensuring alignment across stakeholders and se...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$95K - $115K *

Drive excellence in Life Sciences construction by overseeing project execution, ensuring safety compliance, and maintaining quality standards. Your leadership will be key in managing teams and deliver...

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Elevate your career by leading client relationships and driving revenue growth for consumer product brands in the D2C ecommerce space. Utilize your expertise to coach teams, innovate strategies, and o...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$161K - $242K *

Join a team that's driving strategic initiatives and digital transformation. Collaborate with senior leaders to tackle complex challenges, influence decision-making, and ensure successful execution of...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$102K - $152K *

Transform executive support by leading a dynamic team of EAs, enhancing processes, and driving strategic initiatives that align with company goals while fostering a collaborative culture...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Lead the growth of datacom solutions by building strong teams and partnerships. Develop inventory strategies and execute market initiatives across an 8-state region, driving collaboration and relation...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.