Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Staff Product Manager, Care Coordination
$185K - $215K *
Empower families by leading product management for care coordination systems. Drive AI integration to enhance workflows, ensuring timely resolution of family needs while collaborating with diverse car...
Today
Principal Product Manager, Revenue Cycle Management
$155K - $194K *
Empower the Revenue Cycle Management team by leading product strategy and execution. Drive innovation in financial workflows, ensuring customer insights shape solutions that enhance operational effici...
Yesterday
Senior Director, Software Engineering
$145K - $190K *
Lead the charge in designing and optimizing scalable data pipelines using Azure, PySpark, and Airflow. Collaborate with teams to ensure data quality and performance while mentoring engineers and drivi...
3 weeks ago
Director - Digital Operations, Manufacturing Execution
$152K - $202K *
Optimize digital operations for manufacturing execution, ensuring service continuity and platform stewardship. Lead cross-functional teams to enhance performance and reliability across critical manufa...
3 days ago
Senior Director, Business Development
$150K - $180K *
Join a team that's driving growth in the biopharmaceutical sector by developing strategic business relationships, prospecting new clients, and leading sales initiatives to achieve organizational objec...
1 week ago
$100K *
Lead the integration of acquired businesses, ensuring seamless transitions and customer satisfaction while managing project plans, risks, and cross-functional collaboration for successful outcomes...
2 days ago
$235K - $294K *
Champion user-centric design by leading a talented team to enhance product experiences. Collaborate with stakeholders and customers to drive innovative solutions that improve operational efficiency an...
Yesterday
IT Project Manager - Technical
$73K - $146K *
Champion the delivery of a technical roadmap, ensuring seamless integration and modernization of systems. Collaborate with teams to manage dependencies, drive release readiness, and translate technica...
Today
Program Manager - United Concordia Dental
$94K - $151K *
Shape the future of enterprise strategy by leading a diverse portfolio of programs and initiatives. Collaborate with cross-functional teams to drive measurable business value and ensure alignment with...
3 weeks ago
$88K - $105K *
Manage the feasibility study process by adapting surveys, ensuring quality checks, and monitoring site engagement. Collaborate with teams to execute strategies and maintain effective communication thr...
4 days ago
$100K - $120K *
Engage with cross-functional teams to drive clinical trial success across regions. Leverage your expertise in project management and mentoring to ensure compliance, quality, and timely execution of st...
2 weeks ago
Operations Manager – Digital Services
$95K - $115K *
Champion the modernization of electrical services through project management of transformer digital service projects, ensuring scope, budget, and customer satisfaction while coordinating cross-functio...
Reposted 3 weeks ago
Director, Product Ownership - Commercial Products & Platforms
$160K - $190K *
Advance product strategy and innovation by leading cross-functional teams to drive the vision, roadmap, and delivery of shared commercial platforms, ensuring alignment with business priorities and tec...
2 weeks ago
Anaplan Product Owner, Manager
$91K - $190K *
Drive the charge in advancing Anaplan strategies, leading diverse teams to optimize solutions that align with business objectives. Collaborate with stakeholders to enhance the Anaplan ecosystem and en...
1 week ago
Product Manager - Data Migration
$113K - $197K *
Unlock the potential of product strategy and execution by leading cross-functional teams to deliver innovative solutions. Drive enterprise transformations and ensure alignment with business objectives...
2 weeks ago
$175K - $210K *
Join a team that's redefining merchant capabilities by leading engineering efforts to modernize payment solutions. Drive innovation, manage cross-functional teams, and ensure operational excellence wh...
Today
Transmission & Structural Project Manager
$125K - $150K *
Drive impactful projects in electric utility by managing engineering design, client coordination, and business development. Leverage your expertise to enhance project scope, budget, and schedule while...
3 weeks ago
$101K - $125K *
Drive the execution of immersive projects by providing technical oversight and support, ensuring seamless integration and coordination with partners globally while maintaining high standards of qualit...
1 week ago
Principal Technical Product Manager, Data & Platform
$152K - $222K *
Transform the D&S Palantir Foundry platform by ensuring optimal performance, security, and governance. Lead cross-functional teams to deliver data products and manage resources, costs, and access whil...
Yesterday
Operations/Product Director, Workflow & AI
$150K - $250K *
Champion innovation by optimizing workflows and AI-driven operations to enhance efficiency across diverse business functions. Collaborate closely with teams to build scalable systems that drive real i...
Reposted yesterday
Senior Director of Account Management
$150K - $180K *
Lead a dynamic account management team, driving strategic relationships with major health systems. Foster high-touch engagement, ensuring customer success and operational excellence while directly man...
3 weeks ago
Symphony Project Manager PMO/IT
$95K - $115K *
Champion project success by coordinating business and technology initiatives, ensuring adherence to quality and regulatory standards while managing cross-functional teams to deliver on time and within...
3 weeks ago
$85K - $102K *
Reimagine project management as you lead diverse MEP design operations, ensuring quality, timely delivery, and strong client relations across multiple sectors. Drive team performance while fostering p...
Reposted 2 days ago
Manager - Project Management (Grid Services)
$95K - $115K *
Advance complex electrical equipment projects by leading teams, managing scope, cost, and schedules. Drive execution and ensure milestones are met while fostering collaboration across stakeholders in...
2 days ago
Senior Technical Program Manager
$127K - $175K *
Champion the execution of security and privacy initiatives, aligning cross-functional teams to reduce risks and enhance outcomes. Drive strategic planning, maintain clear communication, and prepare ex...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.