Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$185K - $215K *

Empower families by leading product management for care coordination systems. Drive AI integration to enhance workflows, ensuring timely resolution of family needs while collaborating with diverse car...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$155K - $194K *

Empower the Revenue Cycle Management team by leading product strategy and execution. Drive innovation in financial workflows, ensuring customer insights shape solutions that enhance operational effici...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$145K - $190K *

Lead the charge in designing and optimizing scalable data pipelines using Azure, PySpark, and Airflow. Collaborate with teams to ensure data quality and performance while mentoring engineers and drivi...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$152K - $202K *

Optimize digital operations for manufacturing execution, ensuring service continuity and platform stewardship. Lead cross-functional teams to enhance performance and reliability across critical manufa...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$150K - $180K *

Join a team that's driving growth in the biopharmaceutical sector by developing strategic business relationships, prospecting new clients, and leading sales initiatives to achieve organizational objec...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K *

Lead the integration of acquired businesses, ensuring seamless transitions and customer satisfaction while managing project plans, risks, and cross-functional collaboration for successful outcomes...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$235K - $294K *

Champion user-centric design by leading a talented team to enhance product experiences. Collaborate with stakeholders and customers to drive innovative solutions that improve operational efficiency an...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$73K - $146K *

Champion the delivery of a technical roadmap, ensuring seamless integration and modernization of systems. Collaborate with teams to manage dependencies, drive release readiness, and translate technica...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$94K - $151K *

Shape the future of enterprise strategy by leading a diverse portfolio of programs and initiatives. Collaborate with cross-functional teams to drive measurable business value and ensure alignment with...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Manage the feasibility study process by adapting surveys, ensuring quality checks, and monitoring site engagement. Collaborate with teams to execute strategies and maintain effective communication thr...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Engage with cross-functional teams to drive clinical trial success across regions. Leverage your expertise in project management and mentoring to ensure compliance, quality, and timely execution of st...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Champion the modernization of electrical services through project management of transformer digital service projects, ensuring scope, budget, and customer satisfaction while coordinating cross-functio...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$160K - $190K *

Advance product strategy and innovation by leading cross-functional teams to drive the vision, roadmap, and delivery of shared commercial platforms, ensuring alignment with business priorities and tec...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$91K - $190K *

Drive the charge in advancing Anaplan strategies, leading diverse teams to optimize solutions that align with business objectives. Collaborate with stakeholders to enhance the Anaplan ecosystem and en...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$113K - $197K *

Unlock the potential of product strategy and execution by leading cross-functional teams to deliver innovative solutions. Drive enterprise transformations and ensure alignment with business objectives...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $210K *

Join a team that's redefining merchant capabilities by leading engineering efforts to modernize payment solutions. Drive innovation, manage cross-functional teams, and ensure operational excellence wh...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Drive impactful projects in electric utility by managing engineering design, client coordination, and business development. Leverage your expertise to enhance project scope, budget, and schedule while...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$101K - $125K *

Drive the execution of immersive projects by providing technical oversight and support, ensuring seamless integration and coordination with partners globally while maintaining high standards of qualit...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$152K - $222K *

Transform the D&S Palantir Foundry platform by ensuring optimal performance, security, and governance. Lead cross-functional teams to deliver data products and manage resources, costs, and access whil...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$150K - $250K *

Champion innovation by optimizing workflows and AI-driven operations to enhance efficiency across diverse business functions. Collaborate closely with teams to build scalable systems that drive real i...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Lead a dynamic account management team, driving strategic relationships with major health systems. Foster high-touch engagement, ensuring customer success and operational excellence while directly man...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$95K - $115K *

Champion project success by coordinating business and technology initiatives, ensuring adherence to quality and regulatory standards while managing cross-functional teams to deliver on time and within...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $102K *

Reimagine project management as you lead diverse MEP design operations, ensuring quality, timely delivery, and strong client relations across multiple sectors. Drive team performance while fostering p...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Technical Services

$95K - $115K *

Advance complex electrical equipment projects by leading teams, managing scope, cost, and schedules. Drive execution and ensure milestones are met while fostering collaboration across stakeholders in...

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$127K - $175K *

Champion the execution of security and privacy initiatives, aligning cross-functional teams to reduce risks and enhance outcomes. Drive strategic planning, maintain clear communication, and prepare ex...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.