Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$80K - $96K *

Innovate with us to lead complex, multi-phase projects, ensuring timely delivery and quality standards. Collaborate with cross-functional teams and external partners to drive project success while man...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$125K - $150K *

Innovate the integration of construction projects by collaborating across teams and ensuring operational readiness. Drive compliance, project management, and strategic leadership to deliver projects t...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Transform patient safety operations by leading a dedicated team, ensuring compliance, and enhancing pharmacovigilance processes. Collaborate cross-functionally to deliver high-quality safety services...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $150K *

Unlock potential by leading utility projects with a focus on safety, quality, and budget adherence. Collaborate with teams to ensure successful execution while mentoring staff and managing client rela...

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$216K - $318K *

Drive innovation as you lead engineering teams to build and scale Life360's critical platforms. Ensure reliability and security while fostering a culture of accountability and technical excellence for...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$111K - $161K *

Transform the future of energy efficiency by leading a $200M facility upgrade project. Oversee construction, engage stakeholders, and ensure compliance with safety standards while managing resources a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$75K - $112K *

Unlock potential by managing complex billing processes and leading a team to ensure accurate invoicing and exceptional customer service. Collaborate across departments to drive efficiency and implemen...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$94K - $164K *

Elevate project outcomes by managing medium to high complexity initiatives, ensuring timely delivery, stakeholder engagement, and adherence to best practices throughout the project lifecycle...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Transform client experiences by leading enterprise software implementations. Drive project success with effective stakeholder communication and collaboration across teams while ensuring alignment with...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$118K - $222K *

Empower the delivery of transformative technology initiatives by collaborating with leaders to enhance project execution, manage dependencies, and drive value across teams, ensuring successful outcome...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in operational readiness and logistics strategies to enhance production efficiency. Drive continuous improvement initiatives while coordinating cross-functional teams to ensure seamles...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Transform your career by managing custom automation projects from design to delivery. Lead cross-functional teams, ensure customer satisfaction, and drive financial results while navigating complex pr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$207K - $250K *

Unlock your potential as you lead engineering teams in building innovative platforms and AI experiences. Collaborate across departments to drive technical direction and elevate team performance while...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$185K - $215K *

Empower families by leading product management for care coordination systems. Drive AI integration to enhance workflows, ensuring timely resolution of family needs while collaborating with diverse car...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$155K - $194K *

Empower the Revenue Cycle Management team by leading product strategy and execution. Drive innovation in financial workflows, ensuring customer insights shape solutions that enhance operational effici...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$145K - $190K *

Lead the charge in designing and optimizing scalable data pipelines using Azure, PySpark, and Airflow. Collaborate with teams to ensure data quality and performance while mentoring engineers and drivi...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$152K - $202K *

Optimize digital operations for manufacturing execution, ensuring service continuity and platform stewardship. Lead cross-functional teams to enhance performance and reliability across critical manufa...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$150K - $180K *

Join a team that's driving growth in the biopharmaceutical sector by developing strategic business relationships, prospecting new clients, and leading sales initiatives to achieve organizational objec...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K *

Lead the integration of acquired businesses, ensuring seamless transitions and customer satisfaction while managing project plans, risks, and cross-functional collaboration for successful outcomes...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$235K - $294K *

Champion user-centric design by leading a talented team to enhance product experiences. Collaborate with stakeholders and customers to drive innovative solutions that improve operational efficiency an...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$73K - $146K *

Champion the delivery of a technical roadmap, ensuring seamless integration and modernization of systems. Collaborate with teams to manage dependencies, drive release readiness, and translate technica...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$94K - $151K *

Shape the future of enterprise strategy by leading a diverse portfolio of programs and initiatives. Collaborate with cross-functional teams to drive measurable business value and ensure alignment with...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Manage the feasibility study process by adapting surveys, ensuring quality checks, and monitoring site engagement. Collaborate with teams to execute strategies and maintain effective communication thr...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Engage with cross-functional teams to drive clinical trial success across regions. Leverage your expertise in project management and mentoring to ensure compliance, quality, and timely execution of st...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Champion the modernization of electrical services through project management of transformer digital service projects, ensuring scope, budget, and customer satisfaction while coordinating cross-functio...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.