Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$130K - $155K *

Manage complex cybersecurity verification programs across large-scale data center projects. Lead coordination among diverse teams, ensuring operational readiness and technical integration throughout c...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$150K - $180K *

Lead the charge in shaping product strategy and execution for a key applications portfolio, driving innovation and growth through AI integration while mentoring a high-performing team in a dynamic hea...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$106K - $177K *

Unlock potential by leading cross-functional teams to shape product strategy, drive growth, and enhance customer value through data-driven insights and innovative solutions across the full product lif...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$121K - $160K *

Advance your career by managing financial operations for project teams, enhancing reporting accuracy, and leading financial analysis to support clinical trials and strategic decision-making...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Unlock the potential of supply chain excellence by leading integrated planning, inventory management, and data analytics. Drive cross-functional collaboration to enhance operational performance and cu...

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $130K *

Drive customer success by leading global teams, improving retention, and enhancing product utilization, ensuring a seamless experience across diverse regions and platforms while driving operational ex...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Langan is seeking a Senior Site/Civil Project Manager specializing in Data Centers and Critical Facilities to lead design, permitting, and client management efforts for land development projects. This...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Drive exceptional land development projects in data centers. Lead multi-discipline teams, manage client relationships, and ensure successful project execution from concept through completion, empoweri...

Reposted 6 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$140K - $200K *

Transform decision-making by leading financial planning and analytics efforts. Oversee reporting, data governance, and deliver actionable insights for stakeholders to drive performance, profitability...

Reposted 5 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$125K - $150K *

Shape the future of supply chain planning and data analytics by leading integrated processes, optimizing inventory, and driving cross-functional collaboration to enhance operational performance and cu...

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$84K - $142K *

Join a dynamic team to lead project implementations, manage budgets, and drive customer success. Collaborate with cross-functional experts to deliver impactful solutions for federal clients, enhancing...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Grow your career with impactful project management in global health initiatives. Lead diverse teams across 20-25 countries, ensuring effective execution of polio and health security programs while fos...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$100K - $150K *

Drive growth by building strategic partnerships and closing new business opportunities. Utilize a consultative approach to address client needs with innovative out-of-home solutions, while managing yo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$150K - $195K *

Contribute to the success of IVD and CDx programs by leading cross-functional teams through development, validation, and submission processes. Drive strategic execution and ensure alignment with regul...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Advance organizational change initiatives by leading Oracle Cloud transformations. Collaborate with stakeholders to ensure successful adoption through strategic planning, training, and communication...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Staffing

$126K - $168K *

Lead the charge in shaping and executing product strategy for B2B learning solutions, driving innovation and market impact while collaborating with cross-functional teams to deliver high-quality produ...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $155K *

Lead the charge in operational excellence for a defense technology client, driving technical hiring, change management, and safety compliance. Collaborate with cross-functional teams to ensure alignme...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $200K *

Manage advanced product development programs for data center infrastructure, collaborating with cross-functional teams to drive comprehensive manufacturing strategies, optimize operations, and ensure...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $165K *

Join a team that's redefining insurance technology delivery by leading SaaS implementation programs. This hands-on role combines project management with team leadership to ensure successful client out...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $160K *

Join a team that's dedicated to delivering high-quality projects while mentoring future leaders. As a Senior Project Manager, you'll oversee project teams, ensure profitability, and foster strong clie...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Lead the transformation of healthcare IT by managing ServiceNow projects, enhancing workflows, and ensuring seamless integration. Collaborate with cross-functional teams to deliver innovative solution...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$145K - $222K *

Transform power generation projects by leading development, financing, and execution efforts. Collaborate with diverse stakeholders to deliver high-quality consulting services while managing multiple...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Technical Services

$100K - $120K *

Join a team that's dedicated to optimizing project planning and cost control for renewable energy initiatives. Lead efforts in scheduling, compliance, and reporting to ensure project success from ince...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Drive financial excellence by leading a high-performing FP&A team, enhancing visibility into business drivers, and partnering with executives to influence strategic outcomes in a fast-paced, science-d...

RemoteRemote

3 days ago

  •   11 - 15 years exp.  •   Food & Beverages

$124K - $208K *

Champion financial leadership across diverse Electrical Power Transmission portfolios, driving profitability, cash flow, and execution discipline. Collaborate with cross-functional teams to enhance pr...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.