Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$150K - $180K *

Transform global data migration and AI automation strategies, leading teams to enhance delivery quality and customer value. Drive innovation, operational excellence, and scalable methodologies while f...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Transform enterprise data governance by leading strategy, enhancing quality, and ensuring responsible use. Collaborate with senior leaders to integrate governance into priorities and drive measurable...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Lead the charge in transforming organizational culture and effectiveness by partnering with senior leaders to embed impactful behaviors and practices. Drive measurable change and foster collaboration...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's committed to delivering high-quality project management and engineering services, driving project execution and client satisfaction across various industries while leveraging your e...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$125K - $150K *

Drive the evolution of a comprehensive Product Security program, overseeing security integration across multiple product offerings. Collaborate with teams to enhance security practices while ensuring...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$157K - $185K *

Lead project controls initiatives, balancing technical and people leadership. Oversee major programs, mentor teams, and advise clients while contributing to strategic improvements and governance frame...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$88K - $105K *

Lead the charge in managing diverse commercial interiors projects, enhancing client relationships, and driving design excellence. Collaborate with teams to deliver innovative solutions while expanding...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$130K - $170K *

Join a team that's advancing enterprise talent strategy through data-driven performance management, succession planning, and organizational effectiveness, partnering with leaders to build high-perform...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$80K - $110K *

Lead environmental remediation projects, ensuring safety and compliance while managing teams and client relationships. Oversee proposal preparation, cost estimates, and project execution across variou...

4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$180K - $210K *

Elevate creative excellence by leading a multidisciplinary team, setting vision and quality standards, and driving impactful brand strategies across diverse channels in a dynamic healthcare environmen...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in managing complex public safety projects, ensuring timely delivery and high customer satisfaction. Oversee a diverse portfolio while collaborating with cross-functional teams to driv...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Lead the integration agenda for Customer Development, driving alignment across functions and ensuring successful execution of complex initiatives while managing risks and dependencies...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$95K - $158K *

Transform the Property Intelligence platform by connecting customer needs with product insights. Collaborate across teams to enhance product adoption and engagement through analytics and feedback, dri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$149K - $205K *

Elevate innovation at the forefront of foodtech, agritech, and infrastructure. Lead strategic initiatives, build ecosystems, and drive new ventures to shape the future landscape of Mitsubishi Electric...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$109K - $145K *

Champion growth by leading cost management for critical projects, ensuring value and efficiency. Collaborate with diverse teams to drive strategic initiatives and foster strong client relationships wh...

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$120K - $145K *

Lead and optimize manufacturing processes across multiple sites, driving operational excellence and continuous improvement. Collaborate with cross-functional teams to enhance efficiency, reliability...

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Empower cross-functional teams to deliver complex programs aligned with strategic goals. Lead governance, manage risks, and ensure financial health while driving stakeholder engagement and continuous...

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Elevate program delivery by leading complex, cross-functional initiatives, ensuring alignment with strategic objectives and driving decision-making. Foster collaboration among teams while managing ris...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$140K - $170K *

Advance project execution by managing vendor relationships and internal teams to deliver a new web-based application. Oversee timelines, risks, and stakeholder alignment to ensure successful project o...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Staffing

$63K - $98K *

Lead the charge in ensuring seamless onboarding for new customers, coordinating efforts across teams to deliver a professional transition from sales to support, while fostering strong relationships an...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in delivering high-value design-build projects, ensuring quality execution from design to completion. Collaborate with diverse teams and mentor staff while managing budgets and client...

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$130K - $165K *

Empower growth by leading strategic partnerships in the insurance sector. Drive revenue and client retention through innovative solutions and deep industry insights, while managing complex sales cycle...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Advance global clinical trials by leading cross-functional teams, ensuring compliance and operational excellence while managing timelines and budgets to deliver impactful results in Oncology research...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$225K - $265K *

Partner with us to lead a high-performing engineering team, driving innovation and efficiency in our travel marketplace. You'll manage project lifecycles, enhance collaboration, and champion a custome...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$157K - $283K *

Lead the charge in driving business growth by developing strategic partnerships and innovative solutions for federal clients, while collaborating with cross-functional teams to deliver exceptional res...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.