Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Lead the charge in transforming portfolio execution through strategic initiatives, enhancing governance, and driving measurable outcomes across multiple business areas to deliver lasting value and imp...

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$92K - $98K *

Partner with us to drive impactful federal proposals, managing the lifecycle from analysis to submission. Collaborate with diverse teams to create compliant, compelling proposals that align with strat...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate organizational success by leading complex HR projects, ensuring alignment with business goals. Utilize advanced project management skills to drive initiatives that enhance employee experiences...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$170K - $272K *

Lead and innovate within a dynamic team, driving strategic initiatives and managing cross-functional projects to enhance service offerings and achieve business objectives...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Transform patient access to specialty medications by leading implementation projects, optimizing workflows, and collaborating with clinical teams to enhance pharmacy experiences and resolve issues eff...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$134K - $249K *

Drive procurement governance strategy and compliance across the organization. Oversee contract standards, audit readiness, and policy implementation while ensuring ethical practices and effective comm...

Missouri, USRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Drive the successful execution of multiple e-discovery projects, collaborating with legal teams and mentoring junior staff. Ensure quality standards, manage budgets, and maintain client relationships...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Join a team that's dedicated to delivering innovative solutions through effective project management. Lead cross-functional teams to ensure projects meet customer needs, timelines, and budgets while c...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$200K - $235K *

Drive product excellence by owning the lifecycle and security of high-performance client SaaS platforms hosted on AWS. Lead a dedicated team to optimize operations, ensure compliance, and deliver seam...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$171K - $326K *

Champion strategic project delivery by overseeing staff, budgets, and governance. Drive performance improvements and enhance organizational capabilities while aligning IT initiatives with business goa...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$159K - $211K *

Drive enterprise technology portfolio strategy and governance, ensuring effective delivery management and performance visibility. Collaborate with leadership to translate strategy into actionable init...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Drive impactful change by optimizing product operations through collaborative process design, ensuring alignment and efficiency while fostering innovation and simplification across complex product tea...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$96K - $125K *

Deliver cross-functional project management and business analysis for complex initiatives, ensuring timely and compliant project execution while collaborating with stakeholders to drive measurable val...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Lead the charge in defining user experience strategy, managing a multi-disciplinary design team to deliver innovative, user-centered digital products while fostering collaboration and high-impact desi...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$108K - $130K *

Drive successful battery energy storage projects by managing installations, ensuring quality, and maintaining customer satisfaction. Collaborate with cross-functional teams to deliver projects on time...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Pioneer effective operations by leading teams in specialty construction projects, ensuring safety, quality, and efficiency. Collaborate with stakeholders to navigate challenges and uphold company valu...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$161K - $190K *

Drive strategic planning and scheduling for large-scale capital programs, focusing on data center delivery. Lead teams, establish best practices, and influence stakeholders to ensure successful projec...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$94K - $266K *

Engage with clients to manage Salesforce projects, ensuring timely delivery of cloud solutions. Lead cross-functional teams, facilitate requirements sessions, and maintain strong stakeholder relations...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$138K - $180K *

Shape the future of medical device development by driving project execution, collaboration, and innovation within a dynamic Research & Development team focused on enhancing healthcare outcomes and pat...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$185K - $344K *

Transform analytics modernization and productivity by leading strategy, governance, and process evolution. Collaborate with cross-functional teams to enhance workflows, drive AI adoption, and optimize...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Shape the future of healthcare IT by managing complex integration programs, driving Lean-Agile adoption, and ensuring successful delivery of enterprise reporting and analytics initiatives across multi...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$113K - $164K *

Lead the charge in enhancing client success by strategically advising high-impact clients, fostering executive relationships, and driving solution adoption while mitigating risks and ensuring measurab...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$195K - $208K *

Reimagine user experiences by leading design for core product features, ensuring seamless integration and customer delight. Collaborate across teams to enhance engagement and trust, shaping the future...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Champion enablement initiatives across Technical and Sales domains, partnering with experts to define and execute programs. Lead content development, delivery, and continuous improvement efforts to en...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Drive strategic planning and operational excellence for a dynamic Marketing & Communications team. Own budgeting, resource management, and cross-functional partnerships while leading initiatives that...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.