Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Lead complex healthcare project initiatives, ensuring successful implementation and operational readiness while maintaining high standards of governance. Foster strong partnerships with clients, manag...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion the end-to-end management of complex healthcare programs, ensuring operational readiness and compliance. Collaborate with teams and clients to drive successful implementations while maintaini...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $105K *

Transform virtual resettlement services by leading a national portfolio that enhances access for refugees. Oversee strategy, implementation, and compliance while fostering partnerships and innovative...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$225K - $275K *

Lead the charge in redefining Total Rewards strategy, enhancing compensation, equity, and benefits to attract and retain top talent while anticipating workforce shifts driven by AI and market trends...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$200K - $250K *

Champion the Order to Cash (O2C) product management, overseeing finance operations globally. Lead a team to drive efficiency, ensure compliance, and manage system enhancements. Collaborate with senior...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$80K - $95K *

Empower your career by managing complex projects from inception to completion. You'll oversee proposals, budgets, and team coordination, ensuring adherence to safety and quality standards while delive...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$182K - $198K *

Build and lead a robust Service Management Office to enhance IT operations, ensuring effective governance, accountability, and continuous improvement across a complex 24x7 environment, while fostering...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$85K *

Join us to lead commercial construction projects, ensuring safety, quality, and timelines are met. Collaborate with clients, vendors, and teams from preconstruction to closeout, driving project succes...

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$152K - $226K *

Elevate technical delivery and systems analysis for banking products. Lead cross-functional teams to translate business needs into technical requirements, ensuring successful implementation and ongoin...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$135K - $160K *

Shape the future of K-12 sales by leading a dynamic team of Account Executives. Drive performance through strategic planning, precise forecasting, and collaborative initiatives to achieve growth targe...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$175K *

Optimize revenue cycle management by leading a dynamic team to enhance processes, drive automation, and ensure compliance in a fast-paced telehealth environment. Collaborate with cross-functional team...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $140K *

Drive engineering excellence by managing diverse electrical projects, ensuring compliance with industry standards, and fostering collaboration across teams to achieve strategic objectives and enhance...

3 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Pioneer the strategy and execution of data platforms and AI products, leading cross-functional teams to enhance commercial life sciences solutions while driving revenue growth and product adoption in...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$128K - $214K *

Empower cross-functional teams to deliver complex technical programs, ensuring alignment with business goals. Lead planning, execution, and stakeholder communication while fostering a collaborative en...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $135K *

Lead the strategic planning and execution of complex programs across multiple teams, ensuring alignment with business priorities and effective risk management. Drive delivery improvements and maintain...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Lead the charge in transforming portfolio execution through strategic initiatives, enhancing governance, and driving measurable outcomes across multiple business areas to deliver lasting value and imp...

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$92K - $98K *

Partner with us to drive impactful federal proposals, managing the lifecycle from analysis to submission. Collaborate with diverse teams to create compliant, compelling proposals that align with strat...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate organizational success by leading complex HR projects, ensuring alignment with business goals. Utilize advanced project management skills to drive initiatives that enhance employee experiences...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$170K - $272K *

Lead and innovate within a dynamic team, driving strategic initiatives and managing cross-functional projects to enhance service offerings and achieve business objectives...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Transform patient access to specialty medications by leading implementation projects, optimizing workflows, and collaborating with clinical teams to enhance pharmacy experiences and resolve issues eff...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$134K - $249K *

Drive procurement governance strategy and compliance across the organization. Oversee contract standards, audit readiness, and policy implementation while ensuring ethical practices and effective comm...

Missouri, USRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Drive the successful execution of multiple e-discovery projects, collaborating with legal teams and mentoring junior staff. Ensure quality standards, manage budgets, and maintain client relationships...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Join a team that's dedicated to delivering innovative solutions through effective project management. Lead cross-functional teams to ensure projects meet customer needs, timelines, and budgets while c...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$200K - $235K *

Drive product excellence by owning the lifecycle and security of high-performance client SaaS platforms hosted on AWS. Lead a dedicated team to optimize operations, ensure compliance, and deliver seam...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$171K - $326K *

Champion strategic project delivery by overseeing staff, budgets, and governance. Drive performance improvements and enhance organizational capabilities while aligning IT initiatives with business goa...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.