Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$110K - $130K *

Drive project success by leading high-value construction initiatives from concept to completion. Collaborate with diverse teams, manage budgets, and ensure safety while mentoring staff to deliver inno...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K - $115K *

Advance your career by leading complex projects that drive strategic goals. Collaborate with cross-functional teams to ensure timely delivery, compliance, and risk management while enhancing business...

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in managing complex projects that drive strategic goals. Oversee project lifecycles, ensuring timely delivery, compliance, and stakeholder engagement while fostering collaboration acro...

St. Louis, MORemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $148K *

Transform global congress planning by leading cross-functional teams, managing timelines, and ensuring quality execution. Drive strategic alignment and operational excellence to deliver impactful cong...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Optimize our product suite to elevate financial advisory capabilities through innovative AI solutions. Lead the entire product lifecycle, collaborating with diverse teams to transform complex workflow...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $150K *

Lead the charge in managing complex, technically sophisticated projects, focusing on data centers. Collaborate with diverse stakeholders to ensure project alignment with client goals, budgets, and sch...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$108K - $130K *

Drive the delivery of a preconstruction platform by managing vendor engagement, overseeing validation phases, and ensuring quality gates are met. Collaborate across teams to achieve a production-ready...

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$195K - $230K *

Drive growth by leading go-to-market strategies for TMC partnerships, building and executing plans from the ground up. Collaborate cross-functionally to influence product development and represent the...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Lead the strategy and development of digital publishing products, enhancing workflows and user experiences. Collaborate across teams to create a cohesive ecosystem that supports efficient content mana...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$115K - $145K *

Engineer innovative systems and processes to enhance product delivery, ensuring cross-functional teams operate efficiently and effectively. Drive execution, manage stakeholder alignment, and facilitat...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$77K - $91K *

Lead the charge in delivering exceptional project management services, ensuring seamless communication and collaboration with builders while achieving safety and quality goals throughout the project l...

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$200K - $250K *

Champion product security initiatives by leading a skilled team, architecting compliance frameworks, and managing incident response to enhance trust across all products and stakeholders...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$159K - $287K *

Drive growth and lead strategic partnerships as you oversee P&L performance and business strategy for key global accounts, ensuring operational excellence and customer satisfaction while managing high...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$90K - $120K *

Champion project success by leading data center initiatives, ensuring quality delivery, profitability, and strong customer relationships while managing teams and coordinating with departments to meet...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Elevate your career by leading strategic finance pilots to drive AI model training and evaluation. This hands-on role combines financial expertise and operational leadership to transform emerging proj...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Shape the future of homebuilding by leading a small team of engineers to develop innovative solutions. Balance technical ownership and people leadership while driving impactful projects from concept t...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$122K - $177K *

Unlock potential by leading HRIS strategy and optimization, overseeing a team to enhance Workday and UKG systems. Drive transformation and collaboration across HR, Finance, and Operations for impactfu...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $115K *

Join a team that's redefining healthcare project management. Lead integrated initiatives, mentor talent, and drive excellence across diverse campaigns while fostering collaboration and innovation in a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Take ownership of large-scale construction projects, managing stakeholders and ensuring compliance. Oversee project governance, track milestones, and enhance processes while fostering client relations...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$148K - $193K *

Join a dynamic team as a Program Manager, leading complex projects from inception to completion. Collaborate with diverse stakeholders, manage resources, and drive innovation while ensuring client sat...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$88K - $105K *

Join our team to lead IT projects that enhance technology and optimize processes. Collaborate across functions to drive improvements, ensuring alignment with business goals while fostering a culture o...

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$140K - $160K *

Elevate financial planning and analysis as you lead consolidated forecasts, enhance reporting quality, and partner with executives to drive strategic decisions. Utilize AI and automation to optimize p...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

$143K - $208K *

Join a dynamic team as you lead enterprise-wide manufacturing strategy, ensuring performance and scalability across multiple facilities while driving cross-functional collaboration and continuous impr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$155K - $410K *

Transform your career by leading large-scale SAP implementations, setting strategic direction, and mentoring future leaders while ensuring operational efficiency and client alignment across multiple e...

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

$155K - $410K *

Shape the future of SAP implementation by leading large-scale programs, defining strategic objectives, and mentoring teams to deliver innovative solutions that enhance operational efficiency and clien...

3 weeks ago

  •   8 - 10 years exp.  •   Legal & Accounting

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.