Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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1,000+

Director, Project Management Jobs in Mississippi

Sort By: Relevance

$173K - $290K *

Champion innovation in product development platforms, driving strategy and execution for AI-first tools that enhance collaboration and efficiency across teams. Lead the evolution of platforms, ensurin...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$184K - $253K *

Drive global pharmacovigilance efforts by managing safety data, leading clinical development strategies, and collaborating across teams to enhance product safety and efficacy throughout their lifecycl...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $190K *

Help us shape the future of AI operations by leading a dynamic team focused on innovative solutions, strategic partnerships, and technical excellence in agentic environments. Drive growth and operatio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $141K *

Lead the product direction for membership operations, balancing customer needs and enterprise requirements. Collaborate with teams to enhance workflows, improve operational outcomes, and ensure a seam...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Business Services

$139K - $250K *

Lead the charge in driving strategic product development for a diverse insurance portfolio, collaborating with stakeholders to enhance performance and achieve revenue targets throughout the product li...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $200K *

Lead and shape a high-performing Security Engineering and Operations team, driving proactive threat management and strategic engineering initiatives across North America while enhancing operational ef...

RemoteRemote

Today

  •   11 - 15 years exp.  •   Media

$150K - $180K *

Empower our team to build innovative security and governance solutions, shaping access management for both human and agent users. Lead a small, dynamic group as we define architectural foundations and...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Drive quality assurance excellence by leading the development of scalable processes that enhance student recruitment and enrollment, ensuring compliance and continuous improvement across all interacti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$170K - $200K *

Shape the future of international financial reporting by leading statutory and sustainability reporting for global entities, ensuring compliance and accuracy while collaborating with cross-functional...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Consumer Technology

$150K - $189K *

Elevate organizational efficiency by leading Workday Absence and Time Tracking solutions. Collaborate cross-functionally to optimize processes, ensuring compliance and enhancing user experience as the...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $178K *

Accelerate progress at the forefront of cloud security governance, leading a dynamic team to enhance compliance, drive automation, and ensure robust risk management across multi-cloud environments...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$220K - $250K *

Drive the product roadmap for Unify Release Orchestration, enhancing developer experience while coordinating releases across multiple services, engaging customers, and leading initiatives for AI-nativ...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$241K - $448K *

Drive the Americas Commercial Legal team, leading negotiations on complex software agreements while fostering collaboration and developing talent. Engage with stakeholders to ensure legal alignment an...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$160K - $210K *

Join a dynamic team to shape financial systems that drive growth and innovation. You'll own the strategy for money movement and banking, collaborating across departments to enhance reliability and sca...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $190K *

Unlock potential by managing complex technical programs that drive innovation and operational excellence. Collaborate with cross-functional teams and clients to ensure successful delivery of large-sca...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Lead cross-functional projects in health plan relations, enhancing revenue cycle performance and outcomes. Utilize strong communication and project management skills to coordinate initiatives, track p...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$136K - $160K *

Drive transformation by partnering with architecture and engineering firms to enhance workflows through AI-enabled solutions. Collaborate with stakeholders to redefine processes, ensuring operational...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $130K *

Champion product innovation by owning a defined area from conception to delivery. Collaborate across teams to prioritize solutions that enhance customer experiences and drive measurable impact, all wh...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Enterprise Technology

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Empower operational excellence by leading mission-critical facility management, ensuring seamless integration across diverse functions, and driving strategic initiatives for performance improvement an...

3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Champion the execution of AI initiatives across the enterprise by overseeing project governance, planning, and cross-functional coordination, driving effective delivery from concept to measurable outc...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $185K *

Join a team that's driving strategic sourcing excellence in Facilities for Retail accounts. Lead a dedicated team to deliver innovative solutions, manage supplier relationships, and ensure high-qualit...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$120K - $160K *

Elevate business growth by driving strategic sales initiatives across key sectors. Leverage your network to build relationships and develop tailored solutions, while collaborating with partners to enh...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $130K *

Manage enterprise-wide MarTech programs, aligning cross-functional teams to drive B2C marketing initiatives. Translate business priorities into actionable plans, ensuring effective collaboration and m...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$115K - $192K *

Elevate operational excellence by leading process design and transformation initiatives. Drive automation, quality management, and continuous improvement to enhance client data operations and ensure s...

RemoteRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.