Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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1,000+

Director, Project Management Jobs in Mississippi

Sort By: Relevance

$100K - $120K *

Help us drive change management initiatives in life sciences R&D, enhancing efficiency and effectiveness across research, clinical, and regulatory operations while leading stakeholder engagement and a...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Lead cross-functional teams to drive program success from kickoff to completion, ensuring alignment with customer requirements and managing cost, schedule, and performance across multiple defense manu...

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $145K *

Join a team that's shaping the future of cloud infrastructure by leading engineering efforts for a cutting-edge Operational Decisioning Platform. Drive innovation, enhance developer experience, and en...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$175K - $225K *

Contribute to the growth of our retail segment by leading human capital strategies that optimize talent acquisition, performance management, and organizational design in alignment with business object...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$113K - $197K *

Lead the charge in defining product strategy and roadmap, translating business objectives into actionable plans. Collaborate with cross-functional teams to ensure successful implementation and operati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$229K - $267K *

Innovate the consumer digital experience by leading a cross-functional team to enhance our website, mobile app, and web portal. Define a multi-year vision, prioritize initiatives, and drive engagement...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $150K *

Drive HRIS excellence by optimizing technologies and core processes, enhancing compliance, and delivering impactful solutions that elevate operational efficiency and employee experience across the org...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$155K - $170K *

Lead the charge in shaping enterprise business solutions through hands-on architecture and delivery in Microsoft Dynamics 365 Finance & Operations, focusing on integration, process optimization, and o...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Staffing

$130K - $150K *

Lead change management initiatives by strategizing and implementing processes that support organizational transformation. Collaborate with teams to minimize risks and enhance project outcomes across d...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$88K - $147K *

Lead the charge in operational excellence by managing a dynamic Facility Services team, enhancing customer experience, and driving business growth through effective service delivery and continuous imp...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $170K *

Lead a dedicated team to drive client success across diverse delivery modes, ensuring effective governance and coordination. Drive business development within a portfolio, nurturing critical client re...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Shape complex, cross-functional programs that drive enterprise transformation, focusing on Customer Data Platform implementation and AI initiatives. Collaborate with diverse teams to ensure strategic...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$115K - $140K *

Partner with us to lead PaaS delivery initiatives, ensuring effective operations, solid stakeholder management, and strategic oversight for veteran services. Drive project lifecycles, enhance delivery...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$138K - $150K *

Elevate your career by managing corporate portfolio growth through strategic projects and business development in a dynamic environment. Collaborate with leadership and cross-functional teams to drive...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $150K *

Analyze and manage corporate portfolio growth through strategic projects and business development. Collaborate with cross-functional teams to drive M&A initiatives and evaluate market opportunities, e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Lead the evolution of our GTM Systems Architecture, enhancing Salesforce and its tech stack for AI-native workflows. Collaborate with cross-functional teams to build a trusted data foundation and driv...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$185K - $256K *

Elevate the market growth strategy for biologics research, driving software adoption and AI use cases. Collaborate with global teams and engage with industry leaders to shape the future of molecular t...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$163K - $224K *

Join a team that's redefining People Operations by leading global service delivery, enhancing employee experiences, and driving operational excellence across Talent Acquisition and People processes fo...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Join a team that's shaping the future of financial management in R&D. Drive project budgets, forecasts, and insights while collaborating with cross-functional teams to ensure financial efficiency and...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$105K - $125K *

Lead technology operations for global teams, optimizing systems and support. Collaborate on strategic AI solutions, ensuring compliance and enhancing workflows. Drive efficiency and innovation in a dy...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Transform complex organizational dynamics by designing strategic communication and operational frameworks for a large product team. Lead initiatives that align with overarching company goals, ensuring...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$110K - $130K *

Elevate your career by leading Infor M3 ERP implementations. Drive project success through strategic planning, client management, and cross-functional collaboration while ensuring timely delivery and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $119K *

Drive the commissioning of renewable energy projects, managing teams to ensure all testing and installation meets safety standards and project goals. Collaborate across functions for seamless project...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$130K - $160K *

Lead the charge in project controls management, ensuring effective cost, schedule, and risk oversight across diverse programs. Collaborate with teams to deliver actionable insights that drive successf...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Transform complex customer implementations into seamless successes by owning the delivery lifecycle, driving technical discussions, and ensuring stakeholder satisfaction from kickoff to go-live. Your...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.