Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From positions in Jackson and the Gulf Coast to opportunities in communities across the state, find roles that match your experience, skills, and career goals.

Professional Opportunities Across Mississippi

Mississippi employers hire experienced professionals across industries such as healthcare, finance, manufacturing, technology, energy, and business operations. Available roles and compensation vary by employer, location, and qualifications, so review each listing for details about responsibilities, salary, and requirements.

Search in Mississippi Cities and Regions

Find opportunities in major employment centers including Jackson, Gulfport, and Southaven, as well as other Mississippi communities. Use location and job-title filters to focus your search, and consider remote or hybrid listings when available.

Find a Role That Fits Your Career

Compare opportunities by seniority, specialty, and work arrangement. Keep your résumé current, highlight measurable results, and tailor your application to the qualifications in each listing. Ladders helps professionals explore vetted jobs with salaries of at least $100,000.

Start Your Mississippi Job Search

Browse Mississippi jobs on Ladders and take the next step toward a professional opportunity aligned with your expertise and compensation goals. Listings change frequently, so check back for new roles.

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1,000+

Director, Project Management Jobs in Mississippi

Sort By: Relevance

$122K *

Champion project success by leading interdisciplinary teams to deliver innovative solutions in the biotech and pharma sectors. Drive milestone achievement, manage budgets, and ensure compliance with p...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Transform the landscape of dental negotiations by leading strategic partnerships with payers, optimizing contracts, and driving revenue growth through data-driven insights and collaborative execution...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$102K - $152K *

Transform executive support by leading a dynamic team of EAs, enhancing processes, and driving strategic initiatives that align with company goals while fostering a collaborative culture...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$220K - $290K *

Accelerate the development of autonomous systems by leading systems engineering strategies, aligning cross-functional teams, and ensuring rigorous safety and performance standards throughout the produ...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$132K - $165K *

Shape the future of billing and collections by driving product strategy and enhancing user experiences. Collaborate with cross-functional teams to deliver reliable payment solutions that boost revenue...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$137K - $245K *

Shape the future of physical operations by driving AI-powered product innovation. Collaborate across teams to identify customer needs, prototype solutions, and deliver impactful products that enhance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$137K - $245K *

Lead the charge in driving strategic initiatives and product innovation within the Telematics Business Unit, enhancing core offerings and exploring new market opportunities through hands-on collaborat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$91K - $121K *

Join a team that's pivotal in delivering large-scale PMO projects, managing budgets, schedules, and stakeholder communications. Drive cost control and enhance project performance through expert planni...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$110K - $130K *

Champion operational excellence by leading communication strategies and process improvements. Collaborate with leadership and teams to ensure effective information flow and accountability, driving ini...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Unlock potential by leading client relationships and driving strategic measurement initiatives. Manage a diverse portfolio, ensuring retention and growth while guiding teams to deliver impactful marke...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Lead the charge in multidisciplinary design delivery for data center projects, ensuring buildable, cost-effective designs from planning through construction. Collaborate with teams to meet tenant need...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$194K - $266K *

Champion patient engagement strategies by leading a dynamic team focused on optimizing recruitment and retention across clinical trials. Drive performance, enhance collaboration, and ensure successful...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Lead and develop engineering teams focused on clinical data integration and insights. Drive the direction of data pipelines and ensure impactful, equitable health outcomes through effective collaborat...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$107K - $145K *

Drive growth by identifying and securing new business opportunities in risk management and medical education. Collaborate with teams to develop proposals, manage sales pipelines, and ensure alignment...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$298K - $340K *

Join a dynamic team to lead strategic statistical programming initiatives, ensuring top-quality deliverables and compliance across diverse clinical trials. Collaborate with cross-functional partners t...

United StatesRemote

Reposted 3 weeks ago

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$168K - $228K *

Transform global GxP Change Management processes by leading strategy, governance, and continuous improvement initiatives across the product lifecycle, ensuring effective risk-based changes and collabo...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Lead the charge in transforming supply chain technology strategies, driving innovation and operational excellence across S2P and O2C value streams. Collaborate with cross-functional teams to enhance d...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Elevate the delivery of Salesforce programs by leading end-to-end project management, ensuring compliance, and fostering collaboration across teams to enhance federal application modernization efforts...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$203K - $304K *

Champion innovative operational strategies in clinical research, driving excellence in bid defense meetings and proposal development. Collaborate with cross-functional teams to enhance study execution...

United StatesRemote

2 weeks ago

  •   15+ years exp.  •   Healthcare

$135K - $150K *

Champion growth by leading strategic business development initiatives, forging partnerships, and driving revenue expansion. Collaborate with executives to align goals and enhance market presence while...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $120K *

Accelerate product development by leading end-to-end processes, integrating advanced technologies, and driving outcomes across a suite of digital solutions for legal service operations, while ensuring...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $180K *

Drive product strategy and execution for a critical portfolio area, leading cross-functional teams to transform user insights into impactful software solutions while mentoring others and shaping platf...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$100K - $130K *

Champion innovative methodologies in medical communications, leading Delphi studies and expert panels. Drive strategic insights and deliver scientifically rigorous findings to support clinical develop...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$95K - $115K *

Innovate and enhance educator solutions by leading product management initiatives. Collaborate with cross-functional teams to identify customer needs and drive product development that aligns with str...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$140K - $160K *

Drive operational excellence by leading process and manufacturing engineering initiatives. Collaborate across teams to enhance efficiency, product quality, and scalability while fostering a culture of...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of jobs can I find in Mississippi on Ladders?question toggle

    You can explore professional opportunities across fields such as healthcare, finance, manufacturing, technology, energy, and business operations. Roles and availability vary over time.

  • Are Mississippi jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional jobs that pay $100,000 or more. Check each listing for compensation details, qualifications, and other job-specific information.

  • Where in Mississippi can I search for jobs?question toggle

    Search across the state, including employment centers such as Jackson, Gulfport, and Southaven. You can use location filters to narrow results.

  • How can I find remote or hybrid jobs based in Mississippi?question toggle

    Use available work-arrangement filters or review listing details to identify remote and hybrid opportunities. Availability depends on the employer and role.

  • How do I improve my chances of getting hired for a Mississippi job?question toggle

    Tailor your résumé to the role, emphasize relevant experience and measurable outcomes, and ensure you meet the listed qualifications before applying.