Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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Director, Program Management Jobs in North Carolina

Sort By: Relevance

$110K - $130K *

Unlock potential by leading cross-functional teams to drive product development and customer implementations. Collaborate with stakeholders to ensure successful delivery, manage risks, and refine prog...

1 week ago

  •   5 - 7 years exp.  •   Transportation

$120K - $145K *

Shape complex, cross-functional programs that drive enterprise transformation, focusing on Customer Data Platform implementation and AI initiatives. Collaborate with diverse teams to ensure strategic...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Drive strategic planning and operational excellence for a dynamic Marketing & Communications team. Own budgeting, resource management, and cross-functional partnerships while leading initiatives that...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Lead the charge in shaping product strategy for a key software suite, driving market success by delivering user-focused solutions to major retailers while ensuring alignment with business objectives a...

1 month ago

  •   8 - 10 years exp.  •   Information Technology

$92K - $136K *

Help us drive customer success by owning and optimizing digital engagement programs. You'll lead strategy, build automated journeys, and analyze performance to enhance customer experiences and ensure...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Shape the future of resilience by leading enterprise-wide governance and strategy. Drive continuous improvement in business continuity, crisis management, and technology resilience while collaborating...

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Lead the charge in delivering SAP projects from start to finish, overseeing cross-functional teams and ensuring seamless integration, process improvements, and global template adoption for enhanced op...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Innovate AI-driven growth strategies to enhance HCP and patient outcomes across the commercial funnel. Lead cross-functional teams to implement generative AI solutions, ensuring compliance and measura...

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $220K *

Lead and develop a high-performing R&D project management team, overseeing a diverse portfolio of innovative projects. Drive effective execution while mentoring staff and enhancing cross-business proc...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Optimize the Brand Design team's workflow by managing project intake, ensuring clear briefs, and maintaining organized processes. Collaborate with stakeholders to enhance efficiency and track delivera...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Drive the successful delivery of complex global clinical trials, overseeing cross-functional teams and ensuring compliance with GCP and regulatory standards while managing budgets and timelines to exc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$206K - $309K *

Elevate the Analyst Experience by owning strategy and outcomes for security workflows. Lead a team of product managers to unify analyst tools, drive customer migrations, and enhance product vision, en...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$131K - $176K *

Shape the future of sales excellence by owning end-to-end seller experiences. You’ll optimize workflows, create impactful solutions, and directly influence our revenue systems through innovative produ...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$209K - $287K *

Pioneer innovative strategies in statistical programming, leading global submissions and ensuring compliance. Collaborate cross-functionally to enhance processes and drive excellence in drug developme...

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock your potential as a Program Manager, leading federal service contracts and driving operational excellence. Collaborate with teams to ensure quality delivery, financial performance, and customer...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Explore the dynamic role of a Program Manager, overseeing end-to-end data collection programs. Drive operational excellence, client satisfaction, and strategic execution in a fast-paced environment, e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$232K - $290K *

Lead the charge in optimizing workforce operations and analytics for multi-condition health care services. Develop strategies for capacity planning, staffing, and analytics to drive efficiency and sup...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$90K - $110K *

Champion client success by leading complex implementations, managing risks, and ensuring operational readiness. Collaborate with executive stakeholders to deliver projects on time while maintaining hi...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$209K - $239K *

Drive major technical transformations by leading cross-functional programs that align technology with business goals, ensuring a scalable and efficient delivery of innovative platforms and products fo...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $125K *

Transform data analytics initiatives by leading multiple projects, engaging stakeholders, and driving solutions from inception to delivery. Collaborate with technical teams to ensure alignment with mi...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $160K *

Drive program success by coordinating cross-functional teams, managing reporting, and optimizing engagement strategies for a global enterprise account, ensuring alignment with client goals and employe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$148K - $193K *

Join a dynamic team as a Program Manager, leading complex projects from inception to completion. Collaborate with diverse stakeholders, manage resources, and drive innovation while ensuring client sat...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$117K - $147K *

Empower multi-site data center and AI infrastructure programs valued at $25M+, leading diverse teams to ensure successful delivery, budget management, and customer satisfaction while driving executive...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$135K - $160K *

Lead the charge in building innovative care coordination products, driving strategy and execution across provider and payer segments. Collaborate cross-functionally to ensure alignment and deliver imp...

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Lead complex, cross-functional marketing initiatives from planning to execution, driving accountability and collaboration across teams while enhancing project management processes and methodologies fo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.