Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$100K - $120K *
Elevate clinical research by assisting with study design, medical monitoring, and compliance to ensure effective execution of clinical trials and contribute positively to patient outcomes in alignment...
Reposted 3 weeks ago
Supervising Physician - Dermatology (Remote)
$210K - $250K *
Lead the charge in providing remote clinical oversight for Dermatology PAs, ensuring high-quality patient care and compliance with regulations. Collaborate with a dedicated team to foster clinical exc...
1 week ago
Clinical Specialist, Philadelphia
$80K - $95K *
Empower clinical excellence by delivering expert technical support for neurovascular products. Collaborate with healthcare professionals to enhance patient care, drive product adoption, and ensure suc...
Today
Epic Application Analyst - ClinDoc/Stork
$80K - $95K *
Unlock potential by managing system design, build, and support for applications, ensuring optimal functionality and user satisfaction while collaborating across teams to enhance workflows and resolve...
1 week ago
Clinical Research Associate- Wound Care Experience Required
$95K - $120K *
Elevate clinical trial success by providing expert oversight and guidance. Collaborate with cross-functional teams to ensure compliance, quality, and timely execution of monitoring activities while fo...
2 weeks ago
APP - Nurse Practitioner or Physician Assistant | Interventional Radiology
$90K - $110K *
Champion patient care by performing interventional radiology procedures under supervision. Collaborate with a multidisciplinary team to assess, diagnose, and manage health concerns, ensuring optimal o...
1 week ago
Associate Director, Clinical Data Integration & AI Programming
$158K - $197K *
Unlock potential by leading the automation of clinical data integration and dashboard development. Collaborate across teams to enhance data usability and implement AI solutions, ensuring compliance an...
4 weeks ago
Optometrist - Doctor of Optometry (Employee)
$150K - $200K *
Join a dynamic team to conduct comprehensive eye exams and diagnose ocular conditions using innovative technology. Educate patients on eye care and develop personalized treatment plans in a hybrid wor...
6 days ago
Optometrist - Doctor of Optometry (Employee)
$200K *
Empower patients by delivering exceptional eye care solutions. Conduct comprehensive exams, diagnose conditions, and create personalized treatment plans in a dynamic, patient-centered environment that...
6 days ago
Optometrist - Doctor of Optometry (Employee)
$200K *
Join a team that's dedicated to delivering exceptional eye care solutions while thriving in a dynamic, patient-centered environment. Utilize innovative technology to conduct comprehensive exams and cr...
6 days ago
$110K - $130K *
Unlock potential by leading cross-functional initiatives to enhance caregiver enrollment technology. Drive strategy, optimize user experiences, and leverage data analytics to achieve growth in a dynam...
Today
Account Specialist (Toledo, OH)
$160K - $192K *
Transform healthcare engagement by driving commercial performance and building strong relationships with providers. Collaborate cross-functionally to support product launches and ensure patient access...
6 days ago
Director, Integrated Specialty Practices
$150K - $180K *
Help us drive business development in oncology by leading strategic partnerships and optimizing resources to enhance clinical outcomes and market potential for our innovative diagnostic and therapeuti...
4 weeks ago
$120K - $145K *
Elevate healthcare through strategic AI product management, driving innovation and lifecycle management of AI solutions. Collaborate cross-functionally to align business objectives with customer needs...
1 week ago
Nurse Practitioner / Physician Assistant - Texas
$140K - $150K *
Join a team that's dedicated to transforming addiction treatment through telehealth. Collaborate with physicians to provide comprehensive care for patients with substance use disorders, ensuring a sup...
Yesterday
$110K - $130K *
Transform early phase clinical trials by leading design, execution, and oversight. Collaborate with cross-functional teams to ensure compliance and data integrity while managing project performance an...
4 weeks ago
Medical Director - Inpatient Review
$223K - $313K *
Collaborate with a dedicated team of physicians to ensure high-quality inpatient care through clinical expertise, thorough reviews, and utilization management. Advance patient outcomes by utilizing st...
Reposted 3 weeks ago
Data Analyst (Healthcare Data Analytics)
$80K - $115K *
Analyze and enhance client data reporting, driving insights and trends to support customer satisfaction and business growth. Collaborate with cross-functional teams to ensure data integrity and delive...
3 weeks ago
$80K - $95K *
Transform patient access by optimizing Epic Cadence workflows. Collaborate with clinical teams to enhance scheduling efficiency and support system improvements, ensuring seamless operations and superi...
2 days ago
Medical Safety Manager, Ambulatory Monitoring & Diagnostics
$133K - $237K *
Contribute to patient safety by overseeing medical product surveillance, analyzing data, and ensuring compliance with regulations. Collaborate on risk management and support clinical studies to enhanc...
6 days ago
Medical Director, General Medicine
$180K - $220K *
Drive clinical excellence by providing medical expertise across therapeutic areas, ensuring safety and integrity in clinical trials. Collaborate with project teams and senior management to enhance cli...
2 weeks ago
Senior Account Director (Medical Affairs)
$155K - $175K *
Lead the charge in client partnerships while driving strategic growth and team development. Utilize your expertise to deliver impactful insights and solutions in a fast-paced, evolving environment, en...
Reposted 1 week ago
$72K - $107K *
Join a team that's dedicated to enhancing resident development through effective program management, collaboration with clinical leaders, and innovative professional development sessions to ensure a s...
Today
$80K - $100K *
Drive innovative palliative care solutions for members with complex needs, providing compassionate, evidence-based support through telehealth. Collaborate with interdisciplinary teams to enhance patie...
3 weeks ago
Advanced Practice Provider - Clinical Research Oncology
$85K - $100K *
Join a dynamic healthcare team as you manage complex patient populations, collaborating with physicians and nurses to deliver high-quality care. Utilize your expertise in a predominantly outpatient se...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.