Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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$140K - $160K *

Unlock potential by driving the evolution of AWS environments and CI/CD pipelines, enhancing observability and security, while collaborating with engineers to optimize platform reliability and perform...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $185K *

Unlock potential by driving innovative infrastructure solutions for scalable deployments, collaborating with customers to refine requirements, and enhancing operational efficiency through automation a...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $150K *

Join a team that's shaping the future of AI engineering by leading a dynamic group of engineers and Technical Leads. Drive workforce strategy, enhance team capabilities, and ensure sustainable deliver...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Advance your career by driving business development in clinical research and medical imaging. Build strategic client relationships, identify new opportunities, and contribute to innovative healthcare...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $170K *

Drive the evolution of Legal Operations analytics by building scalable data capabilities, modernizing reporting, integrating AI, and establishing predictive models to enhance decision-making and opera...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $160K *

Elevate user experiences by leading the development of innovative web features. Collaborate with cross-functional teams to deliver high-quality, customer-facing applications using modern technologies...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $140K *

Optimize data solutions by collaborating with cross-functional teams to create actionable insights and scalable data products that drive business decisions and enhance operational efficiency...

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$194K - $361K *

Lead the charge in Advanced Analytics & Modeling, driving enterprise Key Drivers Analytics and managing a talented team to deliver impactful insights and solutions across diverse business challenges...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Empower clients by leading data transitions to e-Automate, ensuring timely, high-quality implementations. Collaborate with teams to enhance processes and deliver tailored solutions that meet diverse b...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $160K *

Transform business challenges into innovative solutions by leveraging AI and engineering expertise. Collaborate with stakeholders to identify opportunities, develop full-stack applications, and drive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $225K *

Transform the future of auto claims by designing AI agents that enhance decision-making and streamline processes. Join a dynamic team to build innovative solutions that improve efficiency and accuracy...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$105K - $124K *

Lead and optimize research intern activities, ensuring alignment with project goals and technical standards. Manage workflows, provide coaching, and conduct hands-on research while supporting the Dire...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Explore advanced revenue analysis and month-end controls to ensure accurate invoicing and financial reporting. Collaborate across functions to resolve discrepancies, mentor junior analysts, and drive...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Empower your career by ensuring quality assurance and training for DRG Reviewers. Contribute to improving clinical documentation and auditing processes while fostering an environment of continuous lea...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Lead the charge in marketing analytics by managing a team of professionals, establishing measurement strategies, and delivering actionable insights that enhance marketing effectiveness and drive membe...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $167K *

Drive efficiency at the intersection of product development and customer engagement by building integrations and automations that empower teams with timely, relevant product knowledge and streamline w...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$124K - $171K *

Champion advanced machine learning techniques to develop multimodal AI systems in biomedical applications, collaborating with cross-functional teams to enhance personalized oncology diagnostics and im...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$128K - $252K *

Lead the charge in mobile engineering to create innovative solutions for personalized marketing and digital commerce. Collaborate with global teams to deliver scalable applications, ensuring high-qual...

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$128K - $252K *

Lead the charge in mobile engineering initiatives, focusing on iOS and Android solutions. Collaborate with global teams to deliver scalable applications that enhance customer engagement and drive digi...

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$112K - $132K *

Join a team that's shaping the future of autism care by building robust statistical methodologies. You'll analyze real-world clinical data, ensuring rigorous evaluation of outcomes and social validity...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$183K - $216K *

Innovate the analytical roadmap for ranking and relevance, collaborating with cross-functional teams to enhance user engagement and advertiser outcomes while driving long-term platform economics and s...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$90K - $100K *

Lead the charge in ensuring master data integrity across manufacturing and supply chain operations. Utilize your expertise to analyze, maintain, and enhance ERP/MRP systems, driving data accuracy for...

3 weeks ago

  •   8 - 10 years exp.  •   Staffing

$140K - $160K *

Drive sales growth by engaging with decision-makers in government agencies. Build relationships, identify opportunities, and collaborate with teams to deliver Investigative Intelligence solutions acro...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$163K - $204K *

Unlock potential by leading innovative machine learning methods for cancer detection, collaborating with experts, and mentoring junior scientists to advance research in multi-cancer early detection us...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $180K *

Empower your career by delivering AI observability solutions end-to-end. Collaborate with a cross-functional team to enhance user experiences and drive insights into AI systems, shaping the future of...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.