Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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$63K - $177K *

Elevate your career by conducting advanced digital forensics investigations and developing AI-powered tools. Collaborate with clients and teams to enhance incident response and forensic workflows, dri...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$63K - $177K *

Accelerate progress at the forefront of digital forensics, leading complex investigations and developing AI-driven tools to enhance forensic workflows and client engagement. Collaborate with teams to...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$160K - $170K *

Lead a high-output data science team, driving end-to-end project delivery and technical direction. Engage deeply in data engineering, governance, and production model delivery while collaborating with...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$174K - $250K *

Drive your career forward by partnering with executives to shape AI strategies, lead complex architecture discussions, and deliver tailored solutions that enhance enterprise AI ecosystems and revenue...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$70K - $205K *

Shape innovative strategies and solutions for digital laboratory operations, enhancing scientific intelligence and user experiences while collaborating with clients to transform their R&D and QC envir...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$70K - $205K *

Empower your career by delivering innovative strategies and solutions that transform laboratory operations and scientific intelligence, while collaborating with clients to enhance their digital landsc...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$218K - $256K *

Lead the end-to-end execution of ML systems for identity verification, ensuring the integrity of millions of accounts through advanced models and cross-team collaboration, while mentoring engineers an...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $155K *

Champion digital transformation initiatives by developing strategies and implementing technology solutions for water and wastewater clients, enhancing data management and analytics capabilities to dri...

Today

  •   5 - 7 years exp.  •   Technical Services

$95K - $155K *

Drive digital transformation in environmental engineering by developing strategies and implementing technology solutions for water and wastewater clients. Collaborate with teams to enhance data manage...

Today

  •   5 - 7 years exp.  •   Technical Services

$154K - $232K *

Transform enterprise cloud strategies by leading large-scale migrations to Azure and AWS. Collaborate with global teams to establish architecture standards, ensure security, and drive innovative solut...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$127K - $224K *

Drive impactful product modeling and marketing measurement as a Staff Data Scientist. Own the lifecycle of ML models, collaborate with PMs, and communicate insights effectively to enhance user experie...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$90K - $110K *

Unlock potential by enhancing revenue operations through data-driven workflows, improving systems, and automating processes. Collaborate with cross-functional teams to ensure efficiency and scalabilit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$160K - $180K *

Unlock potential by leading product marketing initiatives that empower healthcare teams. Drive sales enablement, module marketing, and customer expansion, while shaping messaging and content that reso...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $140K *

Engage with cross-functional teams to develop and refine AI/ML models that enhance Therapeutics Development & Supply. Utilize your expertise in data science to deliver impactful analytical solutions t...

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in developing innovative AI/ML models that enhance Therapeutics Development & Supply. Collaborate with cross-functional teams to deliver impactful data science solutions, driving scien...

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$194K - $272K *

Elevate AI solutions by leading engineering efforts that transform business workflows. Collaborate with teams to identify opportunities, prototype solutions, and implement scalable AI applications tha...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$130K - $195K *

Join a dynamic AI Automation team to design and deliver production-grade AI agents and workflows, enhancing operational efficiency across the organization while solving complex business challenges wit...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$84K - $87K *

Join us as a Data Operations Engineer, where you'll develop and manage data systems for healthcare claims processing. Collaborate with teams to ensure data accuracy and optimize ETL/ELT pipelines whil...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$156K - $180K *

Empower clients by owning technical relationships for the Enterprise Suite, guiding them from discovery to implementation. Collaborate with teams to enhance adoption and resolve issues, ensuring seaml...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$120K - $148K *

Join a team that's shaping the future of AEC software by leading engineering talent and enhancing workflows. Drive innovation in Autodesk Revit add-ins and tools while fostering a collaborative enviro...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $225K *

Join a team that's driving innovation in AI by developing scalable backend systems in Go, Python, and Java. Tackle complex challenges while enhancing distributed architectures to empower high-performa...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$112K - $249K *

Drive innovation in quantitative analytics by developing and enhancing predictive models that support strategic objectives across retail banking. Collaborate with cross-functional teams to deliver act...

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$60K - $120K *

Unlock potential by deploying and supporting advanced robotic systems in diverse environments. Collaborate with teams, troubleshoot issues, and enhance client experiences through effective communicati...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $160K *

Engage in designing and optimizing AI solutions to enhance automation and analytics, collaborating across teams to integrate advanced AI capabilities into core products, while ensuring ethical standar...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$145K - $165K *

Drive your career by owning the end-to-end data platform, designing and maintaining scalable pipelines and infrastructure. Collaborate with analytics teams to ensure data quality and governance while...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.