Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$173K - $245K *

Unlock insights through data analytics and experimentation to enhance credit risk management. Collaborate with cross-functional teams to optimize policies, monitor performance, and drive strategic gro...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Finance & Insurance

$117K - $201K *

Accelerate progress at the forefront of scientific data engineering, combining expertise in AI and data architecture to design interoperable, AI-ready data solutions that drive drug discovery and deve...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Lead the development of innovative scientific data products to enhance AI-driven drug discovery efforts, ensuring effective integration across diverse data domains to support patient safety and transl...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Shape the future of drug discovery by leading the design and implementation of AI-ready scientific data products that enhance drug development and patient safety through innovative data architectures...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $145K *

Analyze and uncover fraud patterns using large-scale data to enhance protection strategies. Collaborate with cross-functional teams to develop insights and solutions that directly impact fraud prevent...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$81K *

Manage and enhance public health technology platforms, ensuring secure, reliable operations for local, state, and federal agencies. Collaborate with cross-functional teams to optimize system performan...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$124K - $280K *

Inspire innovation in healthcare by leading AI and ML solutions development. As a Senior Manager, you'll drive impactful use cases, engage with executives, and oversee global teams to enhance clinical...

3 weeks ago

  •   11 - 15 years exp.  •   Legal & Accounting

$124K - $280K *

Lead the charge in developing AI and ML solutions for health systems, driving innovation and operational excellence. Collaborate with diverse teams to tackle complex healthcare challenges and deliver...

3 weeks ago

  •   11 - 15 years exp.  •   Legal & Accounting

$90K - $110K *

Build and support AI tools and workflows, collaborating with stakeholders to create scalable solutions that integrate with enterprise platforms, ensuring reliability and security throughout the soluti...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$70K - $110K *

Unlock your potential by analyzing data and conducting audits to enhance compliance for innovative B2B and B2C platforms. Collaborate with cross-functional teams, apply critical thinking, and gain ins...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$84K - $126K *

Transform client engagement through data-driven insights and innovative CRM solutions. Lead a dynamic team to enhance client intelligence, streamline processes, and drive strategic marketing initiativ...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$153K - $219K *

Innovate data science solutions to enhance global recognition programs, streamline workflows, and ensure data integrity. Collaborate with stakeholders to translate complex requirements into reliable...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$124K - $207K *

Unlock potential by developing and analyzing KPIs for Medical Affairs, driving data transparency and resource allocation. Collaborate with cross-functional teams to enhance performance metrics and sup...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$132K - $194K *

Unlock potential by leading the strategy and evolution of People technology and analytics. Drive data governance and insights to enhance decision-making and operational efficiency, while partnering wi...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$94K - $293K *

Transform enterprise data into actionable insights by architecting and managing AI-driven platforms. Oversee data governance, integration, and quality to ensure scalable solutions that drive business...

1 month ago

  •   5 - 7 years exp.  •   Business Services

$94K - $293K *

Unlock potential by leading the design and delivery of AI-driven data platforms that transform enterprise data into actionable insights, ensuring technical integrity and business value across diverse...

1 month ago

  •   5 - 7 years exp.  •   Business Services

$265K - $295K *

Shape community engagement strategies to foster trust and collaboration with local stakeholders, ensuring Anthropic's infrastructure projects benefit the communities we serve while navigating complex...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $110K *

Unlock potential by enhancing internal controls and SOX compliance, supporting control owners, and driving risk management initiatives across the Finance function to ensure operational efficiency and...

3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$80K - $95K *

Drive innovation in advanced ceramic armor solutions by acting as the technical liaison between customers and internal teams, ensuring high-quality, manufacturable products that meet diverse defense a...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $220K *

Join a dynamic team as you drive customer success and retention for utility clients. Leverage your expertise to build strong relationships, execute strategic account plans, and elevate our mission in...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Advance your career by designing and deploying innovative AI/ML solutions that enhance operational performance and customer experience across industrial environments, collaborating with cross-function...

2 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$265K - $295K *

Drive community engagement and build trusted relationships with local stakeholders to ensure Anthropic's infrastructure projects are positively received and beneficial to the communities in Louisiana...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $170K *

Unlock the potential of enterprise data architecture by designing secure, scalable solutions for employee data using Databricks. Collaborate with cross-functional teams to implement governance, compli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $170K *

Champion the growth of Audit Manager by driving sales in the healthcare sector. Leverage your expertise in medical billing and coding to engage revenue cycle leaders, manage the sales pipeline, and de...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$121K - $182K *

Partner with us to lead complex cloud migrations, ensuring technical readiness and seamless execution across Azure and AWS environments while driving innovative solutions and high-quality outcomes in...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.