Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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$135K - $145K *

Engineer innovative data solutions by leveraging ML and predictive analytics. Collaborate across product lines to translate user needs into actionable insights, enhancing our data-driven vision and re...

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Transform your career by leading full-cycle recruiting for GTM roles. Collaborate with executives to define hiring standards, build strong talent pipelines, and drive strategic hiring initiatives in a...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$184K - $356K *

Develop metrics and evaluation methodologies to enhance Autonomous Vehicle software. Collaborate across teams to innovate testing strategies and deliver data-driven insights, driving forward cutting-e...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Innovate your career with a key role supporting the global launch and technical operations of radiopharmaceuticals, driving compliance, quality initiatives, and collaboration with CDMOs while leading...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $155K *

Drive innovative machine learning solutions by designing, implementing, and optimizing systems that enhance user experiences across diverse platforms. Collaborate with a dynamic team to deliver impact...

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $105K *

Join a team that's driving operational excellence through data analytics and continuous improvement. Leverage your expertise in manufacturing processes to enhance quality, productivity, and decision-m...

3 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $207K *

Innovate AI and ML systems as a Principal Architect, collaborating with teams to design agentic architectures and scalable solutions. Drive production delivery while shaping standards and best practic...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $140K *

Contribute to the development of a modern platform by building features, connecting systems, and improving data usability. Engage with stakeholders and troubleshoot to deliver reliable software as par...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Staffing

$95K - $115K *

Engage as a Data Visualization Engineer to design and develop advanced Power BI solutions, leveraging AI for enhanced analytics and user experiences. Collaborate with stakeholders to transform complex...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$115K - $130K *

Join a dynamic team as you provide essential IT support to a distributed workforce. Leverage your troubleshooting skills to resolve technical issues, enhance user experience, and contribute to a colla...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$255K - $290K *

Drive the technical vision for a complex database platform, ensuring scalability and performance. Lead architecture decisions, mentor engineers, and collaborate across teams to enhance data infrastruc...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Empower decision-making by transforming spend data into actionable insights. In this role, you'll develop dashboards, analyze procurement data, and collaborate with teams to enhance visibility and dri...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$138K - $165K *

Champion the development of LLM-powered applications and agentic systems. Drive complex use cases from ambiguous problems to production, ensuring high-quality and scalable AI solutions that address us...

RemoteRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $185K *

Unlock potential by designing and deploying AI systems that enhance translational science, enabling evidence-based recommendations for drug discovery and target validation through innovative technolog...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$122K - $171K *

Unlock potential by driving data-driven insights for Customer Success. Collaborate across teams to enhance customer journeys, optimize growth strategies, and shape analytics foundations that support A...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Join a team that's modernizing critical utility applications. As a Senior Business Analyst, you'll gather requirements, enhance processes, and ensure seamless delivery of solutions while retaining ess...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $190K *

Shape the future of data engineering by leading architectural improvements, enhancing data quality, and driving technical initiatives across diverse business domains. Collaborate with stakeholders to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$70K - $156K *

Champion the development of innovative enterprise applications, leveraging Java, Spring Boot, and Angular. Collaborate with cross-functional teams to deliver scalable solutions that meet complex busin...

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $105K *

Unlock potential by conducting advanced quantitative analyses in behavioral health research. Collaborate with senior investigators on diverse projects, manage data, and produce insightful reports to d...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$118K - $147K *

Drive successful project delivery by implementing cutting-edge AI/ML solutions on Google Cloud. Collaborate with cross-functional teams to develop strategies, conduct client discovery, and provide tec...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$100K - $187K *

Engage clients as a trusted advisor, develop and execute strategic account plans, and drive business growth through effective relationship management in data and analytics services...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$153K - $210K *

Strategize and enhance data integrity across extensive systems, ensuring all operational data is accurate and reliable for key clinical and financial workflows while enabling self-serve analytics for...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$320K - $405K *

Innovate the future of data center power generation and microgrids. Own the architecture for on-site generation and storage systems, ensuring reliable energy solutions that meet demanding load profile...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.