Explore High-Paying Jobs in Pennsylvania

Discover professional opportunities across Pennsylvania with Ladders, where job seekers can explore vetted roles paying $100,000 or more. From major business centers like Philadelphia and Pittsburgh to growing communities throughout the state, Pennsylvania offers opportunities for experienced professionals across a range of industries.

Find Opportunities Across Pennsylvania

Search for roles in Pennsylvania’s largest cities and regional hubs. Whether you’re considering a move to Philadelphia, Pittsburgh, Harrisburg, or another location, you can browse openings and compare opportunities by job title, location, and other relevant criteria.

Explore Industries and Career Paths

Pennsylvania’s economy spans sectors such as healthcare, financial services, technology, manufacturing, education, and energy. The roles available vary by employer and location, so use search filters to focus on positions that align with your expertise, career goals, and preferred work arrangement.

Search Vetted Jobs Paying $100K+

Ladders focuses on professional jobs with salaries of $100,000 or more. Review listings for details about responsibilities, qualifications, compensation, and location, then apply directly to opportunities that match your experience.

Take the Next Step in Your Pennsylvania Job Search

Browse Pennsylvania job listings to find your next career opportunity. Narrow your search by city, function, or seniority to identify roles suited to your background and ambitions.

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$150K - $180K *

Lead the charge in delivering advanced AI-powered solutions using Python. Collaborate with cross-functional teams to tackle complex challenges and drive innovation in Generative AI across diverse proj...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $250K *

Accelerate progress at the forefront of AI technology by building and operating a secure, production-grade platform. Collaborate with business teams to transform AI capabilities into measurable value...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$114K - $145K *

Unlock your potential as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managin...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$122K - $213K *

Transform data solutions by designing and optimizing scalable pipelines that empower analytics and decision-making across the organization. Collaborate with stakeholders to deliver high-performance da...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$87K - $135K *

Unlock your potential by leading a dynamic Knowledge Management program that enhances IT support services, fosters collaboration, and drives efficiency for a large-scale enterprise environment. Make a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$173K - $182K *

Lead the charge in designing and deploying impactful machine learning systems. Collaborate across teams to drive innovation and improve business outcomes in a fast-paced environment, leveraging your e...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$140K - $190K *

Join a team that's transforming clinical trials through advanced data science. Drive the development of predictive models and machine learning algorithms to enhance patient enrollment and trial manage...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $185K *

Lead client engagements in Real-World Data solutions, ensuring operational excellence and strong outcomes. Collaborate cross-functionally to translate client objectives into actionable plans, driving...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Transform customer data integration strategies by leveraging your expertise to guide clients in optimizing data flow into the Fusion platform, ensuring reliability and value across complex environment...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$87K - $135K *

Drive your career forward by leading systems engineering for a cloud-based enterprise system. Engage in architecture development, integration, and modernization efforts while ensuring security and ope...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$200K - $235K *

Transform AI/ML systems by leading end-to-end development of innovative solutions. Tackle complex challenges in medical synthesis and help define and deploy advanced features that enhance user experie...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Business Services

$107K - $195K *

Optimize data architecture to support generative AI applications, enabling robust analysis of diverse datasets. Collaborate with teams to design, implement, and document data foundations, ensuring sea...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Technical Services

$120K - $160K *

Champion the design and implementation of scalable data pipelines, ensuring data integrity and availability. Collaborate with cross-functional teams to optimize data workflows and enhance infrastructu...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Unlock innovative AI/ML solutions by collaborating with cross-functional teams, conducting research, and deploying production-grade microservices. Drive impactful projects with ownership and contribut...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $160K *

Analyze complex operational data to drive insights and improve customer outcomes. Collaborate with cross-functional teams, lead impactful analyses, and create self-service analytics tools to enhance d...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$252K - $300K *

Unlock potential by leading the technical strategy for Data Labs, guiding engineering teams to innovate AI training solutions, and shaping the future of model evaluation and deployment in a rapidly ev...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$130K - $155K *

Transform enterprise conversational AI by leading AI/ML initiatives, driving data science across the AI lifecycle, and optimizing solutions for voice and chat applications while collaborating with cro...

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Empower our privacy program by automating processes, managing data subject requests, and ensuring compliance with GDPR and CCPA. You'll leverage technical skills to build scalable tools and systems, d...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Transform healthcare data solutions by designing scalable architectures, optimizing data pipelines, and ensuring compliance with regulations. Collaborate with cross-functional teams to deliver high-qu...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$87K - $253K *

Elevate enterprise data architecture by leading scalable solutions, guiding teams on best practices, and ensuring robust governance. Drive innovation in data engineering while collaborating with stake...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$94K - $293K *

Drive architectural excellence and governance for enterprise data platforms, guiding teams in scalable design, data quality, and best practices. Collaborate with stakeholders to ensure robust solution...

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$95K - $110K *

Drive impactful insights by analyzing real-world data in the life sciences sector. Collaborate with cross-functional teams to enhance patient care and support evidence-based decision-making through in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $110K *

Empower your career by driving the design and maintenance of robust data solutions, optimizing pipelines, and collaborating with cross-functional teams to ensure data quality and support strategic dec...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$92K - $110K *

Contribute to robust data solutions by designing and optimizing data architectures, collaborating with cross-functional teams, and advancing best practices in data management to enhance reliability an...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Business Services

$128K - $165K *

Empower Fraud Operations by leading AI-driven automation initiatives, enhancing investigative workflows, and delivering actionable insights to optimize fraud detection and prevention efforts across th...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What kinds of high-paying jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior and professional roles across fields such as healthcare, finance, technology, manufacturing, education, and energy. Available positions vary by employer and location.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, and other cities and communities across the state. Browse current listings to see where employers are hiring.

  • Do Pennsylvania jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs paying $100,000 or more. Check each listing for its compensation details and any applicable salary range.

  • How can I narrow my search for jobs in Pennsylvania?question toggle

    Use search filters such as location, job title, industry, and seniority to focus on opportunities that fit your experience and preferences.

  • Are remote or hybrid jobs available in Pennsylvania?question toggle

    Some listings may offer remote or hybrid arrangements, depending on the employer and position. Review each job description for its work-location details.