Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$145K - $160K *
Pioneer data-driven insights by collaborating with cross-functional teams to enhance business strategies. Leverage advanced analytics and visualization skills to drive operational improvements and sup...
3 weeks ago
Knowledge Engineering Associate Director
$150K - $375K *
Elevate your career by owning the methodology and tooling for Code Archaeology. Lead large-scale architectural engagements, shape market perspectives, and drive innovation in enterprise software moder...
1 week ago
AI Agent Operations Specialist, Support
$100K - $120K *
Drive strategic enhancements in AI-powered support tools to optimize customer interactions, ensuring high-quality responses through collaboration, analysis, and continuous improvement for superior use...
Reposted 3 weeks ago
Lead Analyst, People Analytics
$113K - $188K *
Optimize security administration and reporting processes while collaborating with cross-functional teams to enhance data insights and compliance metrics. Drive effective use of Workday tools and ensur...
6 days ago
Analyst (Energy and Climate Modeling)
$80K - $100K *
Unlock insights through quantitative analysis and research, shaping energy policy scenarios while collaborating with stakeholders to enhance philanthropic grantmaking efforts and present findings thro...
Reposted 2 weeks ago
Director, Advanced Analytics and Data Science - Innovation
$174K - $234K *
Shape the future of advanced analytics and AI, driving data-driven solutions across commercial, medical, and clinical operations. Collaborate cross-functionally to deliver insights, enhance decision-m...
Reposted 3 weeks ago
$73K - $212K *
Transform data into actionable insights as a Manager in our Data and Analytics Engineering team. Lead innovative AI solutions, manage client accounts, and inspire teams to exceed expectations while fo...
2 weeks ago
$200K - $250K *
Drive client growth by leveraging industry insights and technical expertise to craft customized solutions that meet the diverse needs of Fortune 500 companies while collaborating across teams to enhan...
Reposted today
$95K - $115K *
Join a team that's driving innovative paid media strategies and leveraging AI to optimize performance across multiple platforms. You'll lead campaign execution, budget management, and testing to enhan...
Reposted 1 week ago
Senior Machine Learning Engineer, Operations Research
$207K - $218K *
Champion innovative machine learning solutions to enhance service availability, optimize routing, and improve fulfillment efficiency in a complex logistics environment, driving profitability and shopp...
Reposted 4 days ago
$155K - $165K *
Develop a cutting-edge data ecosystem as a Senior Data Engineer, enhancing analytics, reporting, and machine learning. Collaborate with cross-functional teams to create efficient pipelines and accessi...
Reposted 1 week ago
$150K - $180K *
Lead the charge in delivering advanced AI-powered solutions using Python. Collaborate with cross-functional teams to tackle complex challenges and drive innovation in Generative AI across diverse proj...
Reposted today
$150K - $250K *
Accelerate progress at the forefront of AI technology by building and operating a secure, production-grade platform. Collaborate with business teams to transform AI capabilities into measurable value...
Reposted 1 week ago
$114K - $145K *
Unlock your potential as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managin...
4 days ago
SENIOR KNOWLEDGE MANAGEMENT ANALYST
$87K - $135K *
Unlock your potential by leading a dynamic Knowledge Management program that enhances IT support services, fosters collaboration, and drives efficiency for a large-scale enterprise environment. Make a...
2 weeks ago
Senior Machine Learning Engineer, Fulfillment
$173K - $182K *
Lead the charge in designing and deploying impactful machine learning systems. Collaborate across teams to drive innovation and improve business outcomes in a fast-paced environment, leveraging your e...
4 days ago
$140K - $190K *
Join a team that's transforming clinical trials through advanced data science. Drive the development of predictive models and machine learning algorithms to enhance patient enrollment and trial manage...
3 weeks ago
Engagement Manager, RWD Consulting & Commercial Analytics Services
$160K - $185K *
Lead client engagements in Real-World Data solutions, ensuring operational excellence and strong outcomes. Collaborate cross-functionally to translate client objectives into actionable plans, driving...
3 weeks ago
$120K - $145K *
Transform customer data integration strategies by leveraging your expertise to guide clients in optimizing data flow into the Fusion platform, ensuring reliability and value across complex environment...
Today
$87K - $135K *
Drive your career forward by leading systems engineering for a cloud-based enterprise system. Engage in architecture development, integration, and modernization efforts while ensuring security and ope...
2 weeks ago
Senior AI / ML Engineer (LLMs)
$200K - $235K *
Transform AI/ML systems by leading end-to-end development of innovative solutions. Tackle complex challenges in medical synthesis and help define and deploy advanced features that enhance user experie...
Reposted 2 days ago
$120K - $160K *
Champion the design and implementation of scalable data pipelines, ensuring data integrity and availability. Collaborate with cross-functional teams to optimize data workflows and enhance infrastructu...
4 days ago
Principal Software Security Architect
$150K - $180K *
Join a team that's redefining the future by leveraging cutting-edge AI to develop innovative machine learning solutions that solve complex business challenges, and actively collaborating across multid...
Reposted today
Director, Analytics & Semantic Layer
$130K - $160K *
Drive the development of a semantic layer for a data and AI organization, defining key metrics and leading an analytics engineering team. Build core models and ensure definitional consistency across v...
2 weeks ago
$120K - $145K *
Unlock innovative AI/ML solutions by collaborating with cross-functional teams, conducting research, and deploying production-grade microservices. Drive impactful projects with ownership and contribut...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.